nephrotic syndrome, which is caused by kidney inflammation and is characterised by a large amount of protein in the urine, swelling, weight gain and high blood pressure
History of fits (seizures), eg epilepsy
Hereditary blood disorders called porphyrias
Low levels of a type of white blood cell (neutrophils) in the blood (neutropenia)
People who have recently received radiotherapy or other chemotherapy treatment.
Rare hereditary problems of glucose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption (Leukeran tablets contain lactose).
Not to be used in
Known sensitivity or allergy to any ingredient.
This medicine should not be used if you are allergic to one orany of its ingredients. Please inform your doctor or pharmacist if you havepreviously experienced such anallergy.If you feel you haveexperienced an allergic reaction, stop using this medicine and inform yourdoctor or pharmacist immediately.
Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy orbreastfeeding. However, other medicines may be safely used in pregnancy orbreastfeeding providing the benefits to the mother outweigh the risks to theunborn baby. Always inform your doctor if you are pregnant or planning apregnancy, before using any medicine.
This medicine may be harmful to an unborn baby. It should be avoided where possible during pregnancy, particularly during the first trimester, unless considered essential by your doctor. In this case the risks to the foetus should be weighed against the benefits to the mother. It is important to discuss this with your doctor.
Pregnant women should avoid handling the tablets, particularly if the tablet coating is damaged.
People taking this medicine should use contraceptive measures to avoid becoming pregnant or fathering a child during treatment, and for at least a few months after treatment is finished. Seek medical advice from your doctor.
Mothers who need to take this medicine should not breastfeed. Seek medical advice from your doctor.
Side effects
Medicines and their possible side effects can affect individualpeople in different ways. The following are some of the side effects that areknown to be associated with this medicine. Because a side effect is statedhere, it does not mean that all people using this medicine will experience thator any side effect.
Decreased production of blood cells by the bone marrow (bone marrow suppression)
Increased risk of infection
Nausea and vomiting
Diarrhoea
Mouth ulcers (oral ulcers)
Skin rashes
Seizures
Liver problems
Serious skin conditions such as Stevens-Johnson Syndrome or toxic epidermal necrolysis
Shaking, usually of the hands (tremor)
Disorder of the peripheral nerves causing weakness and numbness (peripheral neuropathy)
The side effects listed above may not include all of the sideeffects reported by the drug'smanufacturer.For moreinformation about any other possible risks associated with this medicine,please read the information provided with the medicine or consult your doctoror pharmacist.
How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicinesyou are already taking, including those bought without a prescription andherbal medicines, before you start treatment with this medicine. Similarly,check with your doctor or pharmacist before taking any new medicines duringtreatment this one,
