Ezetimibe
Table 5: Effect of Coadministered Drugs on Total Ezetimibe  Coadministered Drug and Dosing Regimen Total Ezetimibe *
 Change in AUC Change in Cmax 
* Based on 10-mg dose of ezetimibe
† Post-renal transplant patients with mild impaired or normal renal function. In a different study, a renal transplant patient with severe renal impairment (creatinine clearance of 13.2 mL/min/1.73 m2) who was receiving multiple medications, including cyclosporine, demonstrated a 12-fold greater exposure to total ezetimibe compared to healthy subjects.
‡ See Drug Interactions (7)
§ Supralox® , 20 mL
Cyclosporine-stable dose required (75-150 mg BID)†, ‡ ↑240% ↑290%
Fenofibrate, 200 mg QD, 14 days ‡ ↑48% ↑64%
Gemfibrozil, 600 mg BID, 7 days ‡ ↑64% ↑91%
Cholestyramine, 4 g BID, 14 days ‡ ↓55% ↓4%
Aluminum & magnesium hydroxide combination antacid, single dose § ↓4% ↓30%
Cimetidine, 400 mg BID, 7 days ↑6% ↑22%
Glipizide, 10 mg, single dose ↑4% ↓8%
Statins   
Lovastatin 20 mg QD, 7 days ↑9% ↑3%
Pravastatin 20 mg QD, 14 days ↑7% ↑23%
Atorvastatin 10 mg QD, 14 days ↓2% ↑12%
Rosuvastatin 10 mg QD, 14 days ↑13% ↑18%
Fluvastatin 20 mg QD, 14 days ↓19% ↑7%
Table 6: Effect of Ezetimibe Coadministration on Systemic Exposure to Other Drugs  Coadministered Drug and its Dosage Regimen Ezetimibe Dosage Regimen Change in AUCof Coadministered Drug Change in Cmax of Coadministered Drug
* See Drug Interactions (7) 
Warfarin, 25 mg single dose on Day 7 10 mg QD, 11 days ↓2% (R-warfarin)↓4% (S-warfarin) ↑3% (R-warfarin)↑1% (S-warfarin)
Digoxin, 0.5 mg single dose 10 mg QD, 8 days ↑2% ↓7%
Gemfibrozil, 600 mg BID, 7 days * 10 mg QD, 7 days ↓1% ↓11%
Ethinyl estradiol & Levonorgestrel, QD, 21 days 10 mg QD, Days 8-14 of 21 d oral contraceptive cycle Ethinyl estradiol0%Levonorgestrel0% Ethinyl estradiol↓9%Levonorgestrel↓5%
Glipizide, 10 mg on Days 1 and 9 10 mg QD, Days 2-9 ↓3% ↓5%
Fenofibrate, 200 mg QD, 14 days * 10 mg QD, 14 days ↑11% ↑7%
Cyclosporine, 100 mg single dose Day 7* 20 mg QD, 8 days ↑15% ↑10%
Statins    
Lovastatin 20 mg QD, 7 days 10 mg QD, 7 days ↑19% ↑3%
Pravastatin 20 mg QD, 14 days 10 mg QD, 14 days ↓20% ↓24%
Atorvastatin 10 mg QD, 14 days 10 mg QD, 14 days ↓4% ↑7%
Rosuvastatin 10 mg QD, 14 days 10 mg QD, 14 days ↑19% ↑17%
Fluvastatin 20 mg QD, 14 days 10 mg QD, 14 days ↓39% ↓27%
Atorvastatin

Table 7: Effect of Coadministered Drugs on the Pharmacokinetics of Atorvastatin  Coadministered Drug and Dosing Regimen  Atorvastatin 
 Dose (mg) Change in AUC * Change in Cmax *
* Data given as x-fold change represent a simple ratio between coadministration and atorvastatin alone (i.e., 1-fold = no change). Data given as % change represent % difference relative to atorvastatin alone (i.e., 0% = no change).
† See Warnings and Precautions (5.1) and Drug Int