部份中文阿维A酯处方资料（仅供参考）
商品名：TIGASON
英文名：Etretinate
中文名：阿维A酯胶囊
生产商：中外制药
チガソンカプセル10/チガソンカプセル25
药用类别名称
角质形成细胞的治疗剂
批准日期：1985年12月
商標名
TIGASON
一般名
エトレチナート（Etretinate）（JAN）
化学名
Ethyl(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate
構造式
分子式
C23H30O3
分子量
354.48
性状：
它是一种黄色粉末。乙酸乙酯, 1, 4-二氧烷, 二氯甲烷, 溶于氯仿, 易溶于丙酮或乙醚, 微溶于已烷, 几乎不溶于甲醇或乙醇 (99.5), 几乎不溶于水。
熔点
104至108°c
药用药理学
本剂用于皮肤角质形成细胞和口腔黏膜的高角质形成细胞病变, 作为对症治疗。 其详细的作用机制尚不清楚, 据信它参与了正常上皮 (生长和分化) 与碎片的重新形成 (降低角质层细胞的粘附)。
适应症
以下疾病是无效和严重的治疗
银屑病组 (寻常型银屑病、脓肿性银屑病、银屑病、红皮、关节性牛皮癣),
鱼鳞病组 (寻常型鱼鳞病、水泡型先天性鱼鳞病、红色皮肤病、非水泡型先天性鱼鳞病、红皮病),
棕榈脚垫角化病, 达里病, 棕榈脚垫脓肿, 角化症红色皮状脓毒症和红斑角化病,
口腔白板病、口腔状瘤、口腔扁平苔藓
用法与用量
通常成人2至4周口服2至3次, 每天40至50毫克作为缓解引入量Etretinato。最大剂量为每天75毫克。 此后, 口服给药, 按照症状, 每一天的10至30毫克1至3倍作为缓解维持量 Etretinato。
在婴儿和儿童中, 2至4周口服每日1.0毫克体重1公斤作为缓解引入量Etretinato 分为1-3次。此后, 口服1至 3次1天体重1公斤0.6~0.8毫克作为缓解维持量Etretinato根据症状。
此外, 年龄、体重, 因症状而适当增加或减少。
包装
胶囊
10:100 胶囊 (PTP)
25:100 胶囊 (PTP)
製造和銷售來源
中外制药
注：以上中文不够完整，使用者以原处方资料为准。
完整说明附件：http://www.info.pmda.go.jp/go/pack/3119001M1020_3_01/
TIGASON Capsule 25（チガソンカプセル25）
Brand name : TIGASON Capsule 25
　Active ingredient: Etretinate
　Dosage form: pale red-brown/pale red-brown capsule (major axis: approx. 17.6mm)
　Print on wrapping: チガソン25mg 
Effects of this medicine
This medicine makes abnormally stiffened part on the skin and the oral mucosa easy to peel off and re-forms normal surface skin and mucosa. It is usually used to treat serious psoriasis and ichthyosis.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you are a patient with hepatic/renal disorder or hypervitaminosis A.
If you are predisposed to have hypertriglyceridemia. (For example, you have diabetes, obesity, alcoholism or lipid metabolism abnormality.)
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<        to be written by a healthcare professional>>
•General dosage regimen: For adults, in order to induce a remission, take 40-50mg of the active ingredient in 2-3 divided doses a day for 2-4 weeks. The maximum daily dosage is 75mg of the active ingredient. After that, in order to maintain remission, take 10-30mg of the active ingredient in 1-3 divided doses a day according to the patient's symptoms.
For infants and children, in order to induce a remission, take 1.0mg/kg of the active ingredient in 1-3 divided doses a day for 2-4 weeks. After that, in order to remain remission, take 0.6-0.8 mg/kg of the active ingredient in 1-3 divided doses a day according to the patient's symptoms.
It should be adjusted according to your disease, age and symptoms in any case.
1 capsule contains 10mg of the active ingredient. Strictly follow the instructions of your doctor/pharmacist.
•Avoid taking this medicine with a great amount of milk or fatty food.
•Take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take a double dose to make up for the missed dose.
•If you took too much of this medicine (more than ordered), check with your doctor/pharmacist.
•Do not stop taking this medicine without the instructions of your doctor.
Precautions while taking this medicine
•This medicine has teratogenic potential (possibility to cause fetal anomaly) and has a higher incidence of side effects. You need to be informed of the side effects until you fully understand them.
•In using this medicine, you need to be informed of precautions mentioned below until you fully understand them. If you agree to them, sign the letter of consent.
•If you have a possibility of pregnancy, you have to wait a few days after your menstruation begins before taking this medicine. Also, you may have a pregnancy test within 2 weeks before taking this medicine.
•If you have a possibility of pregnancy, make sure to avoid pregnancy during use and for at least 2 years after withdrawal of this medicine.
•A male patient must avoid pregnancy during use and for at least 6 months after withdrawal of this medicine.
•You cannot make a blood donation during use and for at least 2 years after withdrawal of this medicine.
•When you have joint/bone pain, contact your doctor immediately. Also, if you are supposed to take this medicine for a long period, you may have to take an X-ray examination, etc.
•This medicine may cause liver damage. For the early detection of the side effects, your liver function will be checked before and 1 month after starting this medication, and also every 3 months during use. Do not forget to undergo it on each designated date.
•A patient with hypertriglyceridemia tends to have lipid metabolism abnormality. So, blood test will be conducted to the patient.
•This medicine may cause hair loss, cheilitis, or desquamation (peeled surface skin).
•Avoid breastfeeding.
Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: cheilitis, desquamation (scurfy thing peeling off), dry mouth, thinning of the skin, pruritus.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•joint pain, sore red skin, red spots and breakable blisters all over the body, lassitude [toxic epidermal necrosis (Lyell syndrome)]
•rash and blister, joint pain, fever [erythema multiforme]
•angialgia, purple bruise, swelling [vasculitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store at room temperature (1-30℃), away from light and moisture.
•Discard the remainder. Do not store them. Ask the pharmacist how to discard.