部份中文钙聚苯乙烯磺酸钠处方资料（仅供参考）
商品名：ARGAMATE 89.29% GRANULES
英文名：Calcium Polystyrene Sulfonate
中文名：钙聚苯乙烯磺酸钠颗粒
生产商：安斯泰来制药
药品简介
ARGAMATE 89.29% GRANULES 5.6g（Calcium Polystyrene Sulfonate）获日本批准-为治疗高钾血症新药物
2013年1月14日，安斯泰来（Astellas）与日本三和化学研究所（Sanwa Kagaku Kenkyusho）推出ARGAMATE颗粒（89.2%，5.6g，通用名：聚苯乙烯磺酸钙[又名为：盐酸呋喃硫胺颗粒]）。
该药是一种高钾血症治疗药物，主要用于预防和治疗急、慢性肾功能不全和肾衰患者的高钾血症.
アーガメイト89.29%顆粒5.6g
药用类别名称
高钾血症改良剂
批准日期：2013年1月
商標名
ARGAMATE 89.29% GRANULES 5.6g
一般名
Calcium Polystyrene Sulfonate　ポリスチレンスルホン酸カルシウム
構造式
本品は不規則に入り乱れた複雑な立体構造を有するが、その構造は部分的には下記で示される。
性状
聚苯乙烯磺酸钙是一种细黄白色~淡黄色粉末, 无异味和味道。水, 很少溶于乙醇 (95) 或乙醚。
操作注意事项
稳定性测试
长期储存试验使用最终包装产品(25°c, 相对湿度 60%, 3年) 的结果, 外观和含量等均在标准范围内, kalimate 89 9.29% 颗粒 5.6G在正常市场分布下被确认为稳定3年。
药用药理学
1. 药理作用
从该制剂中提取的每聚苯乙烯磺酸钙1g的钾交换能力, 符合 "日站" (53 ~ 71mg g, 1.36 ~ 1.36 meq g)的标准。
2. 药效学试验生物等效性试验
从以下两次试验的结果中, 该制剂在生物学上被确认与标准配方 (粉末) 相当。
(1) 钾交换能力比较试验
该制剂, 钾交换能力的标准配方(粉末) 的含量, 随着时间的推移, 在每个试管(KCl溶液) 中测量, 在两个剂的钾交换能力没有明显差异。
(2) 两个肾切除大鼠高钾血症模型的药效学试验
而该制剂, 标准配方对应于含量 (粉末), 两天在两个肾切除大鼠高钾血症, 由于共5次口服, 血清钾值降低效果均相当。
3. 行动机制
聚苯乙烯磺酸盐钙, 不被消化和吸收口服给药, 在结肠附近的肠道, 钾离子在钙离子和肠道中的钙聚苯乙烯磺酸盐交换, 聚苯乙烯磺酸树脂没有受到任何变化, 它是排泄, 因为它是在粪便中。因此, 肠道中的钾被转移到外面。
适应症
高钾血症与急性和慢性肾功能衰竭的相关性
用法与用量
通常成人 1天 16.80~33.60g(15 ~30g 作为聚苯乙烯磺酸钙) 在2-3倍, 一个剂量口服水30至50毫升。另外, 它是适当的增加或减少取决于症状。
包装
5.6g×84包
制造供应商
安斯泰来制药公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整资料附件：http://www.info.pmda.go.jp/go/pack/2190016D1028_1_05/
ARGAMATE 89.29% Granules 5.6g（Calcium Polystyrene Sulfonate，アーガメイト 89.29%顆粒）
Brand name:ARGAMATE 89.29% Granules 5.6g
Active ingredient:Calcium polystyrene sulfonate
Dosage form:slightly yellowish white to pale yellow granules
Print on wrapping:アーガメイト 89.29%顆粒 5.6g, 有効成分 5g, 1 包 5.6g, 高カリウ
ム血症改善剤, ARGAMATE 89.29% Gra.5.6g
Effects of this medicine
This medicine helps to evacuate the excessive potassium in your body by exchanging potassium ion in the intestineand calcium ion of this medicine.
It is usually used for the treatment of hyperkalaemia due to renal failure.
Before using this medicine, be sure to tell your doctor and pharmacist
・If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have intestinal obstruction.
・If you are pregnant or breastfeeding.
・If you are taking any other medicinal products.(Some medicines may interact to enhance or diminish medicinaleffects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
・Your dosing schedule prescribed by your doctor is<<to be written by a healthcare professional>>
・In general, for adults, take 16.80 to 33.60 g (15 to 30 g of the active ingredient) daily, in 2 to 3 divided doses. Takea dose with water (about 30 to 50 mL) . The dosage may be adjustd according to the symptoms. Strictly follow theinstructions.
・If you miss a dose, take a dose as soon as possible. If it is almost time for the next dose, skip the missed dose andcontinue your regular dosing schedule. You should never take two doses at one time.
・If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
・Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include constipation, nausea, loss of appetite, gastric discomfort andhypokalemia (lassitude, muscle weakness, paralysis of limbs) . If any of these symptoms occur, consult with yourdoctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicatedin brackets. If any of these symptoms occur, stop taking this medicine and see your doctorimmediately.
・severe abdominal pain, nausea, vomiting[gastrointestinal perforation]
・stoppage of stool, abdominal pain, abdomen enlarged feeling[intestinal obstruction]
・abdominal pain, diarrhea, melena[large intestinal ulcer]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with yourdoctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
・Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
・Discard the remainder. Do not store them
10/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approvaldetails may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It isimportant to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response,patients should understand their medication and cooperate with the treatment.