部份中文谷胱甘肽处方资料（仅供参考）
通用名称：谷胱甘肽
主要成份
主要成份为谷胱甘肽。
化学名：5-L-谷氨酰-L-半胱氨酰甘氨酸结构式：分子式：C10H17N3O6S 分子量：307.33
性 状
为白色片和无色的澄明溶剂。溶解后的滴眼液为无色的澄明液体。
适应症
角膜溃疡、角膜上皮剥离、角膜炎、初期老年性白内障。
用法用量
每次1～2滴，每日3~5次，滴眼用。
不良反应
有时会出现刺激感、瘙痒感、结膜充血、一过性雾视。如出现上述症状时，应停止给药。
禁 忌
有药物过敏史的患者使用前应请教医师或药剂师。
注意事项
（1）少数病人用后可能出现瘙痒、刺激感、眼部充血、一过性视力模糊等症状，停药后即消失。
（2）不宜与磺胺类、四环素类药合用。
（3）滴眼液需贮放于低温处。
儿童用药
请在医师指导下用药。
老年患者用药
请在医师指导下用药。
孕妇及哺乳期妇女用药
请在医师指导下用药。
药物相互作用
1.谷胱甘肽注射时不得与维生素B12、维生素K3、泛酸钙、乳清酸、抗组胺药、磺胺类药及四环素类药混合使用。
2.谷胱甘肽可减轻丝裂霉素的毒副作用。
药物过量
未见不良反应。
药理毒理
1 生物化学作用：谷胱甘肽在生物化学方面的作用，有报告提到是与氧化还原有关，具有辅酶的作用，与硫醇尿酸（MERCAPTURIC ACID）的生成有关，有其它解毒作用，对含-SH的酶及其它细胞成份均具有保护作用。
2 对眼部损伤的作用：试验证实谷胱甘肽可改善角膜损伤（过敏性角膜炎、由农药而引起的眼损伤、放射性角膜炎），能防止白内障的进展（DINITROPHENOL白内障、放射性白内障）。
药代动力学
眼内组织分布：用35 S-GSH滴入家免眼内，分别对无处置、角膜损伤及白内障组进行研究。由自动放射线摄影所见，各组的角膜、前房、虹彩、巩膜，都显出强烈的放射活性，特别以角膜损伤组的活性为最强。在晶体前囊，各组活性较弱，此种放射活性物质根据柱层析法（COLUMN CHROMATOGR APHY）测定确认为GSH。向晶体的移行量，白内障组及角膜损伤组所得的数值，均较无处置组为高。
贮 藏
1.室温保存；
原处方资料附件：http://www.info.pmda.go.jp/go/pack/1319731Q4030_1_04/
Name of drug classification
Oxyglutathion ocular perfusion / washing solution
Sales name
OP Guard neokull eye perfusion solution 0.0184%
Common name
Oxyglutathione (JAN)
Chemical name
N- (N - γ - Glutamyl - cysteinyl) glycine - (2 → 2 ') - disulfide
Abbreviation
GSSG
Molecular formula
C20 H32 N 6 O 12 S 2
Molecular weight
612.64
Property
Oxyglutathione is a white powder, it has no odor and its taste is slightly sour.
It is very soluble in water, methanol,
It is hardly soluble in ethanol or ether.
It is hygroscopic.
composition
Oxyglutathione solution (upper chamber solution 150 mL)
Ingredients · Content (in 150 mL)
Oxyglutathione 92 mg
Oxyglutathione solution (upper chamber solution 150 mL)
Additive
Glucose, sodium chloride, potassium chloride, sodium hydroxide, hydrochloric acid
Dilution solution (lower chamber liquid 350 mL)
Additive
Magnesium chloride, sodium bicarbonate, sodium acetate hydrate, sodium citrate hydrate, sodium chloride, calcium chloride hydrate, sodium hydroxide, hydrochloric acid
After mixing with diluent (500 mL)
Ingredient · Content (in 1 mL)
Oxyglutathione 0.184 mg (0.3 mmol / L)
Indication or effect
Ophthalmic perfusion and washing during eye surgery (cataract, vitreous, glaucoma)
At the time of use, an oxyglutathione solution and a diluent are mixed, and for ophthalmic surgery intraocular and extraocular perfusion and irrigation are aimed at, and an appropriate amount is usually used as a guideline as follows.
It should be noted that it should be increased or decreased according to the type of surgery and time of operation.
Cataract surgery
60 - 240 mL
Vitreous surgery
90 to 400 mL
Glaucoma surgery
30 - 260 mL
Mixing method (be sure to mix)
Remove the chemical bag from the outer bag.
Push the lower chamber with both hands to open the bulkhead.
Push the upper chamber and lower chamber alternately and mix well.
Medicinal pharmacology
<Bioequivalence test>
The barrier function of the corneal endothelium (limiting the entry of the anterior chamber water into the corneal stroma) and the pumping function (pumping the intrinsic water into the anterior chamber)
It keeps the moisture content of the cornea constant and plays an important role to maintain corneal homeostasis. Therefore, it is important that ocular irrigating fluid like this drug does not lower any function, and bioequivalence is eva luated by comparative test based on the protective action of these functions.
Corneal endothelial barrier function and pump function protection action
The cornea removed from rabbits was immersed in this drug or standard preparation for 6 hours and the wet weight and dry weight of the cornea (dried at 100 ° C. for 16 hours) were measured.
From these values, corneal moisture content (ratio of corneal water content to dry weight) was calculated and compared as an index of corneal endothelial barrier function and pump function protective effect. As a result, the 90% confidence interval of the difference between the average values ​​of both preparations was -0.017 to 0.225, when the ratio to the average value of the standard preparation was -0.47% to 6.08% and the allowable range was set to ± 10% , The bioequivalence of both drugs was confirmed.
Corneal endothelial barrier function protection function
Rabbit corneal endothelial cells were cultured on a membrane, FITC-dextran dissolved Autoclaved or standard preparation was added to the membrane upper layer side and treated for 4 hours,
The amount of FITC-dextran that passed through the endothelial cell layer was compared and examined as an indicator of the protective function of corneal endothelial barrier function. As a result, the 90% confidence interval of the difference in mean value between the two preparations was -0.1424 μg / mL to 0.2024 μg / mL, the ratio to the average value of the standard preparation was -5.50% to 7.81% When set at 10%, the bioequivalence of both drugs was confirmed.