| 简介：
部份中文吡诺克辛处方处方资料（仅供参考）
英文名：Pirenoxine
商品名：CATALIN-K
中文名：吡诺克辛滴眼液
生产商：千寿製薬
カタリン点眼用0.005％
薬效分类名
老人性白内障治疗剤
批准日期：2007年12月
商標名
CATALIN FOR OPHTHALMIC 0.005％
一般名
ピレノキシン（Pirenoxine）〔JAN〕
化学名
1-Hydroxy-5-oxo-5H -pyrido［3, 2-α］phenoxazine-3-carboxylic acid
構造式
分子式
C16H8N2O5
分子量
308.25
性状
吡诺克辛是棕褐色粉末，无臭，味微苦。
它极不溶于二甲基亚砜，几乎不溶于水，乙腈，乙醇（95），四氢呋喃或乙醚。
熔点：约250°C（分解）
处理注意事项
注意
请注意，由于金属离子的混入，本产品会改变色调。
保存
（1）室温保存
（2）溶解后，在阴凉处保存，并在3周内使用。
药效药理
根据喹诺酮理论，据称白内障的原因是晶状体的水溶性蛋白质被有核氨基酸的代谢紊乱（色氨酸，酪氨酸等）产生的喹诺酮物质变性和不溶，而吡咯烷酮是喹诺酮物质。竞争性地抑制了该作用以维持晶状体的透明性，从而抑制了白内障的进展（豚鼠，体外）。
适应症
初期老人性白内障
用法与用量
使用前将颗粒溶解在溶液中，每天滴入1至2滴，每天3至5次。
*有关如何溶解颗粒的详细信息，请参见“其他说明（附带设备的处理）”。
包装
（一个片剂眼科溶液和溶解液15毫升）×10
（一个片剂眼科溶液和溶解液15毫升）×50
制造厂商
千寿药业有限公司
销售
武田制药有限公司
注：以上中文处方资料不够完整，使用者以原处方为准！
完整说明资料附件：
https://www.info.pmda.go.jp/go/pack/1319706Q2039_1_05/
CATALIN FOR OPHTHALMIC 0.005%（カタリン点眼用0.005％）
Brand name: CATALIN FOR OPHTHALMIC 0.005%
Active ingredient:Pirenoxine
Dosage form: orangish yellow tablet, clear and colorless solvent, after dissolution; clear and yellow ophthalmic solution,(solvent bottle)with large white cap and small brown cap
Print on wrapping:
Effects of this medicine
This medicine prevents water-soluble protein in the crystal lens from insolubilization so as to maintain transparency of the lens, and consequently suppresses progression of cataract.
It is usually used to control the progress of early senile cataract.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions(itch, rash, etc.)to any medicines.
If you wear contact lenses.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is<<to be written by a healthcare professional>>
•Dissolve the tablet in the solvent just before use. In general, apply 1 to 2 drops at a time, 3 to 5 times daily. Strictly follow the instructions.
•Following the instruction attached in the box, drop the tablet in the solvent and dissolve it shaking well.
•Before using, wash your hands with soap and water. Then warm the bottle by hand for a while (when you apply the medicine right after taking from cold storage, it may drop successively caused by cold air expanding in the bottle). Remove the small brown cap only while keeping the large white cap tightly closed and apply the medicine not to touch the tip of eye dropper to any surface of your eye. After instilling, close your eyes and do not blink for a while. Wipe off any excess liquid with a clean gauze or tissue. If you need to use other eye drops at the same time, wait more than 5 minutes.
•If you miss a dose, apply a dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should not use two doses at one time.
•If you accidentally use more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop using this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Possible adverse reactions to this medicine
The most commonly reported adverse reactions include blepharitis (eyelid inflammation), contact dermatitis (rash in the area where the medicine is attached), diffuse superficial keratitis (foreign-body sensation, eye pain, sensitive to light, teary eye), conjunctival congestion, conjunctivitis, irritation in the eye, itching in the eye, foggy vision, eye discharge, lacrimation, eye pain, abnormal sensation in the eye and foreign-body sensation in the eye.If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets.If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store at room temperature (1-30℃), away from direct sunlight.
•After dissolution, store away from light in a cold place (1-15℃), and use within 3 weeks.
•Discard the remainder. Do not store them.
•To avoid improper use and quality loss, do not transfer this solution to any other bottle or container.
•Do not use any other solution in this bottle.
Senju Pharmaceutical Co.,Ltd.External
Revised: 12/2013
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
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