剂型
粒为2mg，4mg的片剂，6个毫克片剂
制造商
诺华（瑞士），诺华（印度），诺华（德国），诺华制药公司，由诺华制药有限公司制作（德国），山德士制药有限公司（瑞士），山德士制药有限公司生产的（印度）
FarmGruppa
不同的抗惊厥和解痉药
国际非专有名称
Tizanidine (trade names Zanaflex (Acorda Therapeutics), Sirdalud (Novartis), Relentus (Beximco Pharma)) is a drug that is used as a muscle relaxant. It is a centrally acting α2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, ALS, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. It is also prescribed for some symptoms of fibromyalgia.[2]
Tizanidine has been found to be as effective as other antispasmodic drugs and is more tolerable than baclofen and diazepam.[3] Tizanidine can be very strong even at the 2 mg dose and may cause hypotension, so caution is advised when it is used in patients who have a history of orthostatic hypotension, or when switching from gel cap to tablet form and vice versa.
Tizanidine can occasionally cause liver damage, generally the hepatocellular type. Clinical trials show that up to 5% of patients treated with tizanidine had elevated liver function test values, though symptoms disappeared upon withdrawal of the drug. Care should be used when first beginning treatment with tizanidine with regular liver tests for the first 6 months of treatment. As of 2015 the cost for a typical month of medication in the United States is 100 to 200 USD.[4]
同义词
Tizanil
结构
活性物：替扎尼定。
【药理作用】
Miorelaksiruyuschee（中央）。 兴奋α-2-肾上腺素能受体，主要对脊髓的水平; 减少了从脊髓的中间神经元兴奋性氨基酸的排放，选择性地抑制负责肌张力过高polisinapticheskie机制。 要减少被动运动的肌肉阻力，增加了任意肌肉收缩的强度。 它放松了脊髓和脑起源的慢性痉挛性条件，骨骼肌，消除急性疼痛的肌肉痉挛和阵发性抽搐。 一旦快速，里面几乎完全被吸收。 生物转化在肝脏。 主要写尿英寸
适应症
痛苦的肌肉痉挛在脊柱疾病，（包括腰痛，颈椎病，偏瘫，脊髓空洞症，颈椎和腰椎综合征），手术后一椎间盘突出或臀部，痉挛和疼痛引起的神经系统疾病的骨关节炎：多发性硬化，慢性脊髓病，退行性脊髓疾病，脑循环障碍，中风，创伤性脑损伤，大脑性麻痹，中枢性痉挛。
禁忌
过敏症在肝衰竭和肾功能衰竭，怀孕，哺乳，婴儿期表现。
副作用
嗜睡，肌肉无力，焦虑，睡眠障碍，幻觉，疲劳，头晕，眩晕，血压轻微下降（在低剂量）或高血压，心动过缓，口干，恶心，胃肠紊乱，在血清中转氨酶的暂时增加。
相互作用
降压药，利尿药包括，增加低血压和心动过缓。 酒精和镇静剂深化deprimiruyuschie效果。
过量
症状包括恶心，呕吐，低血压，头昏，瞳孔缩小，呼吸困难，昏迷。 治疗：洗胃，活性炭，强迫利尿，维护的重要功能。
注意事项
当恶化的肝，肾功能，并减少她们剂量的定期监测。 在血液中的转氨酶持续增加，需要停药。 由于可能的困倦和虚弱的建议限制因工作需要快速的生理和心理反应的人的任命。
