美他特龙[89Sr]注射液（Metastron）反应堆生产的一种可供直接静脉注射的镇痛治疗药物，对于多种晚期癌症所造成的骨转移产生的剧烈疼痛有显著的疗效。
【产品性状】： 无色澄明无菌无热原液体
【氯化锶含量】： 10.9~22.6mg
【放射性浓度】： 37MBq/ml
【放射性比活度】： 2.96~6.17 MBq/mgSr
【放射性核纯度】： 99.99％
【物理半衰期】： 50.5天
【衰变的类型】： β-100%
【射线的性质】： β-粒子能量1.46MeV
【化学结构式】： Cl-89Sr-Cl
【产品PH值】： 4.5～7.5
【有效期】：从放射性标定日期开始计算为28天
【治疗原理】
89Sr，在元素周期表上是位于钙（Ca）之后的2A族金属元素，进入体内几乎与钙（Ca）一样参与骨的矿物营养物质代谢并在骨中浓集，是一种亲骨性核素。它对体内钙（Ca）的生物性分布起着平衡作用。前列腺癌、乳腺癌、肺癌等晚期患者，肿瘤细胞会转移至全身骨骼系统，引起患者剧烈骨疼痛。89Sr一次性静脉给药后，很快从血液中清除，绝大部分迅速浓聚于成骨细胞组织，其余由肾脏排出。89Sr在成骨性转移灶病变部位的摄取率大于正常骨组织的10～25倍，而且89Sr在进入骨转移灶病变部位后不再代谢，半衰期50.5天的89Sr将发射β-粒子能量1.46MeV的射线，射线辐射效应对骨转移癌细胞持久杀伤，起到镇痛治疗的作用。骨转移癌患者通常在注射89Sr后1～2周疼痛开始消除，6周时药效达到高峰，一般可以维持疗效4～6个月。
【适应症】
肿瘤骨转移性骨痛可由肿瘤浸润并且蔓延至神经支配丰富的骨膜所致，也可由肿瘤的机械性压迫导致骨组织变薄所致，还可以因为肿瘤从骨组织扩散至神经组织所致。其疼痛使患者难以忍受，摧毁了患者的生存信心。本品不同于毒副作用大、成瘾性强、耐受性差的神经抑制类及膦酸盐类镇痛药物，治疗核素89Sr直接快速定位于发生骨转移灶的病变部位，对晚期癌症所造成的骨转移产生的剧烈疼痛有显著的治疗作用。
*前列腺癌、乳腺癌、肺癌等晚期癌症患者经核医学诊断均有明显的骨转移的。
*为使晚期癌症患者得到最大治疗效果，本品应当在确诊患者有骨转移时，视患者情况尽早使用。
*本品不影响对患者进行其他综合治疗。
【特点】
·治疗效果显著
本品静脉注射后10天左右，大多数患者有明显的镇痛作用，半数以上完全解除痛苦；有部分随访患者可发现骨转移灶部位减小或消失，有效率大于80％。
·治疗有效期长
本品使用一次，疼痛治疗有效期可以达4～6月，半数以上患者不需再使用其他止痛剂，使患者的精神状态得到极大改善。
·体外辐射剂量极低
本品注射后，患者对周围环境及人员无明显的辐射影响，不需进行放射防护，对于经济条件不好的患者便于核医学科医生开展家庭病床治疗，减少了患者的住院费用。
·对造血功能影响小
本品是一种靶向治疗药物，骨转移灶病变部位药物浓聚量很高，正常组织吸收很少，患者单位体重辐射剂量很少，89Sr的β-粒子能量1.46MeV的射线辐射范围是2～3mm，对骨髓造血功能无明显的辐射影响，对白细胞及血小板一次性抑制率在20%以下，对人体无明显毒副作用。
·患者生命质量有效改善
患者使用本品后，一次性治疗，疼痛明显缓解，使患者坚定了生存信心，明显改善生命质量，有了更多时间处理未完成的工作，享受人生之乐的同时减少患者家属的心理压力。

MetastronGeneric Name: strontium chloride sr 89 (Intravenous route, Injection route)
STRON-shee-um KLOR-ide Sr 89
Commonly used brand name(s):
In the U.S.
Metastron
Available Dosage Forms:
Injectable
Solution
Therapeutic Class: Radiopharmaceutical, Antineoplastic
Uses For Metastron
Strontium chloride Sr 89 is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.
Strontium chloride Sr 89 is used to help relieve the bone pain that may occur with certain kinds of cancer. The radioactive strontium is taken up in the bone cancer area and gives off radiation that helps provide relief of pain.
Strontium chloride Sr 89 is to be given only by or under the direct supervision of a doctor with specialized training in nuclear medicine or radiation oncology.
Before Using Metastron
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Studies on this medicine have been done only in adult patients, and there is no specific information about its use in children.
Geriatric
Strontium chloride Sr 89 has been used in older people and has not been shown to cause different side effects or problems in older people than it does in younger adults.
Pregnancy

Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of strontium chloride Sr 89. Make sure you tell your doctor if you have any other medical problems.
Proper Use of Metastron
Your doctor may have special instructions for you to follow to get ready for your treatment. If you do not understand them or if you have not received such instructions, check with your doctor in advance.
If you have a problem controlling your bladder, tell your doctor before receiving strontium chloride Sr 89. Special precautions will need to be taken to prevent contamination of clothing, bed linen, and the environment.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
Precautions While Using Metastron
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects. You may need to have blood tests done regularly.
Follow these guidelines for 1 week after receiving strontium chloride Sr 89, to help reduce the chance of contaminating other persons or the environment:
Use a normal toilet, if available, instead of a urinal.
Strontium chloride Sr 89 is passed in the urine and feces. To prevent contamination of your home environment, flush the toilet twice after using.
Wipe any spilled urine with a tissue and flush it away.
Wash your hands after using or cleaning the toilet .
Wash your clothes and bed linens immediately if they become soiled with your urine or blood. Wash them separately from other clothes.
If you cut yourself, wash away any spilled blood .
Strontium chloride Sr 89 can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If your blood count becomes abnormally low, there are certain precautions you can take, to reduce the risk of infection or bleeding, such as:
With abnormally low white blood cell counts:
If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
With abnormally low platelet blood counts:
Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
Avoid contact sports or other situations where bruising or injury could occur.
Metastron Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. When strontium chloride Sr 89 is used at recommended doses, side effects usually are rare. However, blood problems, such as a decrease in the number of white blood cells or platelets, may occur in some patients.
Check with your doctor immediately if any of the following side effects occur:
Rare
Black, tarry stools
blood in urine or stools
cough or hoarseness
fever or chills
lower back or side pain
painful or difficult urination
pinpoint red spots on skin
unusual bleeding or bruising
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Flushing
increase in bone pain
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.