emorrhage
Not known
Ear and labyrinth disorders
Deafness
Uncommon
Cardiac disorders
1Blood pressure decreased
Very common
1Blood pressure increased
Very common
1Heart beat irregular
Very common
1Palpitation
Very common
1Cardiac flutter
Very common
Ejection fraction decreased*
Very common
+Cardiac failure (congestive)
Common
+1Supraventricular tachyarrhythmia
Common
Cardiomyopathy
Common
Pericardial effusion
Uncommon
Cardiogenic shock
Not known
Pericarditis
Not known
Bradycardia
Not known
Gallop rhythm present
Not known
Vascular disorders
Hot flush
Very common
+1Hypotension
Common
Vasodilatation
Common
Respiratory, thoracic and mediastinal disorders
+1Wheezing
Very common
+Dyspnoea
Very common
Cough
Very common
Epistaxis
Very common
Rhinorrhoea
Very common
+Pneumonia
Common
Asthma
Common
Lung disorder
Common
+Pleural effusion
Common
Pneumonitis
Rare
+Pulmonary fibrosis
Not known
+Respiratory distress
Not known
+Respiratory failure
Not known
+Lung infiltration
Not known
+Acute pulmonary oedema
Not known
+Acute respiratory distress syndrome
Not known
+Bronchospasm
Not known
+Hypoxia
Not known
+Oxygen saturation decreased
Not known
Laryngeal oedema
Not known
Orthopnoea
Not known
Pulmonary oedema
Not known
Interstitial lung disease
Not known
Gastrointestinal disorders
Diarrhoea
Very common
Vomiting
Very common
Nausea
Very common
1Lip swelling
Very common
Abdominal pain
Very common
Dyspepsia
Very common
Constipation
Very common
Stomatitis
Very common
Haemorrhoids
Common
Dry mouth
Common
Hepatobiliary disorders
Hepatocellular injury
Common
Hepatitis
Common
Liver tenderness
Common
Jaundice
Rare
Hepatic failure
Not known
Skin and subcutaneous tissue disorders
Erythema
Very common
Rash
Very common
1Swelling face
Very common
Alopecia
Very common
Nail disorder
Very common
Palmar-plantar erythrodysaesthesia syndrome
Very common
Acne
Common
Dry skin
Common
Ecchymosis
Common
Hyperhydrosis
Common
Maculopapular rash
Common
Pruritus
Common
Onychoclasis
Common
Dermatitis
Common
Urticaria
Uncommon
Angioedema
Not known
Musculoskeletal and connective tissue disorders
Arthralgia
Very common
1Muscle tightness
Very common
Myalgia
Very common
Arthritis
Common
Back pain
Common
Bone pain
Common
Muscle spasms
Common
Neck Pain
Common
Pain in extremity
Common
Renal and urinary disorders
Renal disorder
Common
Glomerulonephritis membranous
Not known
Glomerulonephropathy
Not known
Renal failure
