|
See related Nexavar film-coated tab[蕾莎瓦 膜衣錠] information |
|
|
|
製造商 |
Bayer Schering Pharma |
|
代理/經銷商 |
Bayer Schering Pharma |
|
成份 |
Sorafenib |
|
適應症 |
Advanced renal cell carcinoma who have failed prior interferon-alpha- or interleukin-2-based therapy or are considered unsuitable for such therapy. Child-Pugh A class patients with hepatocellular carcinoma who are unable to undergo surgery & in whom local chemotherapy is unsuitable. |
|
用量 |
Adult 400 mg bid. |
|
用法 |
Should be taken on an empty stomach (Take on an empty stomach or w/ a low or moderate fat meal. If the patient intends to have a high fat meal, sorafenib should be taken on an empty stomach at least 1 hr before or 2 hr after meals. Swallow whole, do not chew/crush.). |
|
美國食品藥物管理局之懷孕等級 |
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). |
|
禁忌 |
Pregnancy & lactation. |
|
注意事項 |
Dermatological toxicities. Monitor BP weekly during 1st 6 week of therapy & thereafter; severe or persistent HTN. GI perforation, hemorrhage, cardiac ischemia &/or infarction. Concomitant warfarin, irinotecan, doxorubicin therapy. |
|
不良反應 |
Erythema, exfoliative dermatitis, acne, flushing, increased lipase, increased amylase, mucositis, stomatitis, dyspepsia, dysphagia. Hemorrhage, asthenia, pain, decreased appetite, influenza-like illness, pyrexia. Leukopenia, lymphopenia, anemia, neutropenia, thrombocytopenia. Hypophosphatemia, transient increases in transaminases. Arthralgia, myalgia. Depression. Impotence. Voice hoarseness.
View ADR Monitoring Website[參閱藥物不良反應監測表格] |
|
交互作用 |
Warfarin, irinotecan, doxorubicin, substrates of CYP2B6 & CYP2C8, UGT1A1 & UGT1A9, rifampin, St. John's wort, phenytoin, carbamazepine, phenobarbital, dexamethasone.
View more drug interactions with Nexavar[蕾莎瓦] |
|
本商品之市售規格 |
|
劑型 |
包裝 |
圖片 |
|
Nexavar 膜衣錠 |
|
Nexavar 200 mg x 60's |
 |
|
|
|
Manufacturer: |
Bayer Schering Pharma |
|
Distributor: |
Bayer Schering Pharma
|
|
|
|
