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See related Leukeran tab[瘤克寧 錠] information |
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製造商 |
GlaxoSmithKline |
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代理/經銷商 |
GlaxoSmithKline |
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成份 |
Chlorambucil |
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適應症 |
Listed in Dosage. |
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用量 |
Hodgkin's disease Monotherapy: 0.2 mg/kg/day for 4-8 week. Non-Hodgkin's lymphoma Monotherapy: 0.1-0.2 mg/kg/day for 4-8 week initially. Maintenance therapy is given by reduced daily dosage or intermitten courses of treatment. Chronic lymphocytic leukaemia 0.15 mg/kg/day until the total leucocyte count has fallen to 10,000/microlitre. Treatment may be resumed 4 week after the end of the 1st course & continued at 0.1 mg/kg/day. Waldenstrom's macroglobulinaemia Starting dose: 6-12 mg daily until leucopenia occurs; followed by 2-8 mg daily indefinitely. |
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過量 |
View Leukeran[瘤克寧] overdosage for action to be taken in the event of an overdose. |
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用法 |
Should be taken on an empty stomach (Take on an empty stomach. Ensure adequate hydration. Swallow whole, do not chew/crush.). |
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美國食品藥物管理局之懷孕等級 |
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). |
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禁忌 |
Pregnancy (1st trimester) & lactation. |
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注意事項 |
Immunization with live vaccines. Monitor blood counts closely. Recently undergone radio- or chemotherapy. In lymphocytic infiltration of bone marrow or hypoplastic bone marrow, max daily dose is 0.1 mg/kg. Monitor closely children with nephrotic syndrome, patients on high intermitten dosing regimens, history of seizure disorders. Renal/hepatic impairment. Mutagenicity & carcinogenicity (chromatid or chromosome damage). Acute myelogenous leukemia with long-term adjuvant therapy for breast cancer. |
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不良反應 |
Acute secondary hematologic malignancies (especially leukemia & myelodysplastic syndrome), particularly after long-term treatment. Leucopenia, neutropenia, thrombocytopenia, pancytopenia. Bone marrow suppression; anemia, seizures in children with nephrotic syndrome; nausea, vomiting, diarrhea, oral ulceration.
View ADR Monitoring Website[參閱藥物不良反應監測表格] |
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交互作用 |
Phenylbutazone, live vaccines.
View more drug interactions with Leukeran[瘤克寧] |
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儲存 |
View Leukeran[瘤克寧] storage conditions for details to ensure optimal shelf-life. |
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本商品之市售規格 |
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劑型 |
包裝 |
圖片 |
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Leukeran 錠劑 |
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Leukeran 2 mg x 25's |
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Manufacturer: |
GlaxoSmithKline |
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Distributor: |
GlaxoSmithKline |
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