See related VFEND[黴飛] information
製造商 Pfizer
代理/經銷商 Arich
成份 Voriconazole
適應症 Treatment of invasive aspergillosis, serious invasive candida infections, serious fungal infections caused by Scedosporium spp. & Fusarium spp.
用量 Tab Loading dose Adult ≥ 40 kg 400 mg 12 hrly for the 1st 24 hr. < 40 kg 200 mg 12 hrly for the 1st 24 hr. Maintenance dose for prevention of breakthrough infections; treatment of fluconazole-resistant serious invasive candidiasis, invasive aspergillosis, Scedosporium & Fusarium infections, & other serious mould infections; esophageal candidiasis in immunocompromized patients Adult ≥ 40 kg 200 mg 12 hrly. Dose may be increased to 300 mg 12 hrly if necessary. < 40 kg 100 mg 12 hrly. Dose may be increased to 150 mg 12 hrly if necessary. Vial IV infusion only. Max rate: 3 mg/kg/hr over 1-2 hr. Adult Loading dose 6 mg/kg 12 hrly for the 1st 24 hr. Maintenance dose for prevention of breakthrough infections 3 mg/kg 12 hrly for the 1st 24 hr. Treatment of fluconazole-resistant serious invasive candidiasis, invasive aspergillosis, Scedosporium & Fusarium infections, & other serious mould infections 4 mg/kg 12 hrly.
過量 View VFEND[黴飛] overdosage for action to be taken in the event of an overdose.
用法 Should be taken on an empty stomach (Take at least 1 hr before or after meals.).
美國食品藥物管理局之懷孕等級
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
禁忌 Hypersensitivity. Coadministration of terfenadine, astemizole, cisapride, pimozide, quinidine, sirolimus, rifampicin, carbamazepine, long-acting barbiturates (e.g. phenobarbital), ergot alkaloids (ergotamine, dihydroergotamine), St. John's worts.
注意事項 Hypersensitivity to other azoles, potentially proarrhythmic conditions, infusion-related reactions. Monitor renal & hepatic function. Avoid intense or prolonged exposure to direct sunlight. Children < 2 years. Concomitant use with methadone, phenytoin, rifabutin, ritonavir, efavirenz. Pregnancy & lactation. May affect ability to drive or operate machine (may cause transient & reversible changes in vision).
不良反應 Fever, peripheral edema, nausea, vomiting, diarrhea, abdominal pain, headache, rash, visual disturbances. Sinusitis, chills, asthenia, chest pain, inj site reaction/inflammation (vial), flu syndrome, lung edema, cheilitis, gastroenteritis, elevated liver function tests, jaundice, cholestatic jaundice, thrombocytopenia, anemia, leukopenia, pancytopenia, hypokalemia, hypoglycemia, back pain, dizziness, tremor, paresthesia, hallucinations, confusion, depression, anxiety, agitation, resp distress syndrome, face edema, pruritus, maculopapular rash, photosensitivity skin reaction, alopecia, exfoliative dermatitis, purpura, hypotension, thrombophlebitis, phlebitis, increased creatinine, acute kidney failure, hematuria.
View ADR Monitoring Website[參閱藥物不良反應監測表格]
交互作用 Coadministration of terfenadine, astemizole, cisapride, pimozide, quinidine, sirolimus, rifampicin, carbamazepine, long-acting barbiturates (e.g. phenobarbital), ergot alkaloids (ergotamine, di
