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See related Ixempra powd for inj information |
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Manufacturer |
Bristol-Myers Squibb |
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Distributor |
DKSH |
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Contents |
Ixabepilone |
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Indications |
In combination w/ capecitabine for the treatment of patients w/ metastatic or locally advanced breast cancer resistant to anthracycline & a taxane or whose cancer is taxane resistant & if further anthracycline therapy is contraindicated. As monotherapy for metastatic or locally advanced breast cancer in patients whose tumors are resistant or refractory to anthracyclines, taxanes & capecitabine.
Click to view Ixempra detailed prescribing infomation |
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Dosage |
40 mg/m2 IV over 3 hr every 3 wk.
Click to view Ixempra detailed prescribing infomation |
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Overdosage |
View Ixempra overdosage for action to be taken in the event of an overdose. |
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Contraindications |
History of severe (common toxicity criteria grade 3/4) hypersensitivity reaction to agents containing Cremophor EL or its derivatives (eg polyoxyethylated castor oil), neutrophil count <1,500 cells/mm3 or platelet count <100,000 cells/m3. Combination w/ capecitabine if AST or ALT >2.5 x ULN or bilirubin >1 x ULN.
Click to view Ixempra detailed prescribing infomation |
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Special Precautions |
AST or ALT >5 x ULN or bilirubin >3 x ULN. History of cardiac disease. DM. Monitor for symptoms of neuropathy, peripheral blood cell counts. Pregnancy, lactation.
Click to view Ixempra detailed prescribing infomation |
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Adverse Drug Reactions |
Peripheral sensory neuropathy, hypersensitivity reactions, fatigue/asthenia, myalgia/arthralgia, alopecia, nausea, vomiting, stomatitis/mucositis, diarrhea, musculoskeletal pain, neutropenia, leukopenia, anemia, thrombocytopenia. Combination treatment: Palmar-plantar erythrodysesthesia syndrome, anorexia, abdominal pain, nail disorder, constipation.
View ADR Monitoring Form |
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Drug Interactions |
Ketoconazole, itraconazole, clarithromycin, atazanavir, nefazodone, saquinavir, telithromycin, ritonavir, amprenavir, indinavir, nelfinavir, delavirdine, voriconazole, grapefruit juice, dexamethasone, phenytoin, carbamazepine, rifampicin, rifabutin, phenobarb, St. John's wort.
View more drug interactions with Ixempra |
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Pregnancy Category (US FDA) |
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). |
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Caution For Usage |
For caution against possible variation of physical aspect of medicine... click to view Ixempra detailed prescribing infomation |
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Storage |
View Ixempra storage conditions for details to ensure optimal shelf-life. |
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Description |
View Ixempra description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Ixempra mechanism of action for pharmacodynamics and pharmacokinetics details. |
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Presentation/Packing |
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Form |
Packing |
Photo |
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Ixempra powder for injection |
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Manufacturer: |
Bristol-Myers Squibb |
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Distributor: |
DKSH
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