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See related Yondelis infusion information |
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Manufacturer |
Janssen-Cilag |
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Distributor |
DKSH |
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Contents |
Trabectedin |
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Indications |
Advanced soft tissue sarcoma after failure of anthracyclines & ifosfamide.
Click to view Yondelis detailed prescribing infomation |
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Dosage |
Starting dose: 1.5 mg/m2 BSA IV infusion over 24 hr w/ a 3-wk interval between cycles. Premed w/ corticosteroids eg dexamethasone 20 mg IV 30 min before each infusion.
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Overdosage |
View Yondelis overdosage for action to be taken in the event of an overdose. |
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Contraindications |
Active serious/uncontrolled infection. Lactation.
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Special Precautions |
Hepatic or renal impairment (CrCl <30 mL/min), neutropenia & thrombocytopenia, rhabdomyolysis & severe CPK elevations (>10 x ULN), liver function test abnormalities, inj site reactions if administered through a peripheral venous line. Avoid concomitant use w/ alcohol. May impair ability to drive or operate machinery. Pregnancy.
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Adverse Drug Reactions |
Neutropenia, thrombocytopenia, anemia, AST/ALT increases, hyperbilirubinemia, nausea, vomiting, diarrhea, constipation, fatigue/asthenia, anorexia, CPK elevations & rhabdomyolysis, alopecia.
View ADR Monitoring Form |
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Drug Interactions |
Ketoconazole, fluconazole, ritonavir, clarithromycin; rifampicin, phenobarb, St. John's wort; cyclosporine, verapamil.
View more drug interactions with Yondelis |
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Caution For Usage |
For caution against possible variation of physical aspect of medicine... click to view Yondelis detailed prescribing infomation |
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Storage |
View Yondelis storage conditions for details to ensure optimal shelf-life. |
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Description |
View Yondelis description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Yondelis mechanism of action for pharmacodynamics and pharmacokinetics details. |
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Presentation/Packing |
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Form |
Packing |
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Yondelis infusion |
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Yondelis 1 mg x 1's |
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Manufacturer: |
Janssen-Cilag |
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Distributor: |
DKSH |
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