See related Coversyl tab information |
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Manufacturer |
Servier |
Distributor |
Zuellig |
Contents |
Perindopril |
Indications |
Essential HTN; CHF; reduction of the risk of stroke recurrence when used in combination w/ indapamide in patients w/ history of stroke or TIA; reduction of CV events in patients w/ stable angina when used w/ other preventive meds.
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Dosage |
HTN 4 mg as single dose, may be increased to a single 8 mg dose. Elderly Start treatment w/ a 2 mg dose. In renal insufficiency, dose has to be adapted according to creatinine clearance. CHF Single oral dose of 2 mg, may be increased to a single 4 mg dose once BP acceptability has been demonstrated. Reduction of risk of stroke recurrence Initial dose 2 mg daily for 2 wk, then increased to 4 mg daily for another 2 wk before introducing indapamide. Reduction of risk of CV event Initially 4 mg daily for 2 wk, then increased to 8 mg depending on renal function. Elderly 2 mg daily for 1 wk, then 4 mg daily the next wk before increasing to 8 mg daily depending on renal function.
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Overdosage |
View Coversyl overdosage for action to be taken in the event of an overdose. |
Administration |
Should be taken on an empty stomach (Take before meals.). |
Contraindications |
Pregnancy, lactation; childn. Bilateral or unilateral renal artery stenosis.
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Warnings |
For additional cautionary notes to warn of the potential risk of using the medicine... click to view Coversyl detailed prescribing infomation |
Special Precautions |
Arterial hypotension, renal failure, water & Na depletion; renovascular HTN; surgery/anesth; elderly. Hemodialysis: avoid combination w/ highly permeable membranes (polyacrylonitrile). Measure plasma creatinine at baseline & during the mth following institution of treatment. May precipitate excessive hypotension in severe CHF w/ or w/o associated renal insufficiency. Patients w/ ischaemic heart disease or cerebrovascular disease in whom excessive fall in BP may result in MI or CVA.
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Adverse Drug Reactions |
GI disorders; dizziness, headaches, mood &/or sleep disorders, asthenia; taste disorder; cramps, localized rash; dry cough; angioneurotic edema.
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Drug Interactions |
K supplements or K-sparing diuretics may induce hyperkalemia esp in renal failure. Diuretics. Neuroleptics or TCAs increase risk of orthostatic hypotension. Serum lithium conc may rise during lithium therapy.
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Pregnancy Category (US FDA) |
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). |
Caution For Usage |
For caution against possible variation of physical aspect of medicine... click to view Coversyl detailed prescribing infomation |
Storage |
View Coversyl storage conditions for details to ensure optimal shelf-life. |
Description |
View Coversyl description for details of the chemical structure and excipients (inactive components). |
Mechanism of Action |
View Coversyl mechanism of action for pharmacodynamics and pharmacokinetics details. |