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See related Actemra inj information |
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Manufacturer |
Roche |
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Distributor |
DKSH |
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Contents |
Tocilizumab |
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Indications |
Moderate to severe active RA in adult. Inhibit progression of joint damage & improve physical function. Active systemic juvenile idiopathic arthritis (sJIA) in patients ≥2 yr.
Click to view Actemra detailed prescribing infomation |
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Dosage |
RA Adult 8 mg/kg once every 4 wk as IV infusion over 1 hr alone or in combination w/ methotrexate (MTX) &/or other DMARDs. sJIA Patient ≥30 kg 8 mg/kg, <30 kg 12 mg/kg. Administer once every 2 wk as IV infusion alone or in combination w/ MTX.
Click to view Actemra detailed prescribing infomation |
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Overdosage |
View Actemra overdosage for action to be taken in the event of an overdose. |
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Special Precautions |
Active infections & hepatic disease, hepatic impairment, low neutrophil count, absolute neutrophil count <0.5 x 109/L. Immunization w/ live & live attenuated vaccines. Pregnancy, lactation.
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Adverse Drug Reactions |
Hypersensitivity, upper resp tract infections, cellulitis, oral herpes simplex, herpes zoster, mouth ulceration, gastritis, rash, pruritus, headache, dizziness, increased hepatic transaminases, HTN, leucopenia, neutropenia, hypercholesterolemia, infusion reactions, immunogenicity.
View ADR Monitoring Form |
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Drug Interactions |
Warfarin, cyclosporine.
View more drug interactions with Actemra |
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Pregnancy Category (US FDA) |
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus. |
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Caution For Usage |
For caution against possible variation of physical aspect of medicine... click to view Actemra detailed prescribing infomation |
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Storage |
View Actemra storage conditions for details to ensure optimal shelf-life. |
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Description |
View Actemra description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Actemra mechanism of action for pharmacodynamics and pharmacokinetics details. |
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