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See related Herceptin infusion information |
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Manufacturer |
Roche |
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Distributor |
DKSH |
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Contents |
Trastuzumab |
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Indications |
Breast cancer: Treatment of patients w/ 1st-line metastatic breast cancer who have tumors that overexpress human epidermal growth factor receptor 2 protein (HER2). Treatment of patients w/ HER2+ve early breast cancer (FISH+ or IHC3+) following surgery, chemotherapy & radiotherapy. In combination w/ an aromatase inhibitor for the treatment of patients w/ hormone receptor positive metastatic breast cancer. Advanced gastric cancer: In combination w/ capecitabine or IV 5-FU & a platinum agent for the treatment of patients w/ HER2 positive advanced adenocarcinoma of the stomach or gastroesophageal junction who have not received prior anticancer treatment for their metastatic disease.
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Dosage |
Wkly schedule: Initial loading dose of 4 mg/kg as 90-min IV infusion, followed by 2 mg/kg wkly until progression of disease. Alternative 3-wkly schedule: Initial loading dose of 8 mg/kg, followed by 6 mg/kg 3 wk later, then 6 mg/kg repeated at 3-wkly intervals. Patients w/ early breast cancer should be treated for 1 yr or until disease recurrence.
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Overdosage |
View Herceptin overdosage for action to be taken in the event of an overdose. |
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Contraindications |
Hypersensitivity.
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Special Precautions |
Preexisting cardiac dysfunction especially in combination w/ anthracycline & cyclophosphamide. Pregnancy & lactation.
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Adverse Drug Reactions |
Abdominal pain, accidental injury, asthenia, back pain, chest pain, chills, fever, flu syndrome, headache, infection, neck pain, vasodilation, GI disturbances, diarrhea, peripheral edema, edema, arthralgia, myalgia, anxiety, depression, dizziness, insomnia, paresthesia, somnolence, asthma, increased cough, dyspnea, epistaxis, lung disorders, pleural effusion, pharyngitis, rhinitis, sinusitis, pruritus, rash, cardiac toxicity, hepatic toxicity. Fever & chills (1st infusion).
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Drug Interactions |
[Click for Herceptin detailed prescribing infomation]
View more drug interactions with Herceptin |
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Pregnancy Category (US FDA) |
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). |
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Caution For Usage |
For caution against possible variation of physical aspect of medicine... click to view Herceptin detailed prescribing infomation |
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Storage |
View Herceptin storage conditions for details to ensure optimal shelf-life. |
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Description |
View Herceptin description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Herceptin mechanism of action for pharmacodynamics and pharmacokinetics details. |
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