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See related Ethyol infusion information |
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Manufacturer |
MSD |
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Distributor |
Zuellig |
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Contents |
Amifostine |
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Indications |
Reduces cumulative renal toxicity associated w/ repeated administration of cisplatin in patients w/ advanced ovarian cancer or non-small-cell lung cancer. Prevents acute & late xerostomia from radiotherapy in head & neck cancer.
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Dosage |
Reduction of renal toxicity associated w/ cisplatin Initially 740-910 mg/m2 once daily as a 15 min IV infusion starting w/in 30 min prior to chemotherapy w/ agents. Radioprotection 200 mg/m2 once daily as a 3 min IV infusion starting 15-30 min prior to radiotherapy. Reconstitute w/ 9.7 mL sterile 0.9% NaCl soln prior to administration.
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Overdosage |
View Ethyol overdosage for action to be taken in the event of an overdose. |
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Contraindications |
Hypotensive or dehydrated patients. Renal or hepatic impairment. Childn & patients >70 yr. Pregnancy & lactation.
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Warnings |
For additional cautionary notes to warn of the potential risk of using the medicine... click to view Ethyol detailed prescribing infomation |
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Special Precautions |
Hydrate patient adequately prior to infusion, keep in supine position & monitor BP. Monitor Ca serum levels in patients at risk of hypocalcaemia eg those w/ nephrotic syndrome.
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Adverse Drug Reactions |
Hypotension, nausea, vomiting, flushing/feeling of warmth, chills/feeling of coldness, dizziness, somnolence, hiccups & sneezing.
View ADR Monitoring Form |
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Drug Interactions |
May potentiate hypotension w/ antihypertensives.
View more drug interactions with Ethyol |
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Pregnancy Category (US FDA) |
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus. |
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Caution For Usage |
For caution against possible variation of physical aspect of medicine... click to view Ethyol detailed prescribing infomation |
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Storage |
View Ethyol storage conditions for details to ensure optimal shelf-life. |
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Description |
View Ethyol description for details of the chemical structure and excipients (inactive components). |
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Mechanism of Action |
View Ethyol mechanism of action for pharmacodynamics and pharmacokinetics details. |
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Presentation/Packing |
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Form |
Packing |
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Ethyol infusion |
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Ethyol 500 mg x 10 mL x 1's |
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Manufacturer: |
MSD |
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Distributor: |
Zuellig |
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