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See related Emend cap information |
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Manufacturer |
MSD |
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Distributor |
Zuellig |
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Contents |
Aprepitant |
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Indications |
In combination w/ other antiemetics for the prevention of acute & delayed nausea & vomiting associated w/ initial & repeat courses of highly or moderately emetogenic cancer chemotherapy.
Click to view Emend detailed prescribing infomation |
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Dosage |
125 mg orally 1 hr prior to chemotherapy (day 1) & 80 mg once daily in the morning (days 2 & 3). Given as part of a 3-day regimen that includes a corticosteroid & a 5-HT3 antagonist.
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Overdosage |
View Emend overdosage for action to be taken in the event of an overdose. |
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Administration |
May be taken with or without food |
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Contraindications |
Concurrent administration w/ pimozide, terfenadine, astemizole or cisapride.
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Special Precautions |
Patients receiving concomitant medications primarily metabolized through CYP3A4. Monitor INR in patients on chronic warfarin therapy. May reduce efficacy of hormonal contraceptives. Pregnancy & lactation.
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Adverse Drug Reactions |
Hiccups, asthenia/fatigue, increased ALT & AST, constipation, diarrhea, dyspepsia, eructation, headache, dizziness, anorexia.
View ADR Monitoring Form |
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Side Effects |
View Emend side effects |
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Drug Interactions |
S(-) warfarin, tolbutamide, phenytoin; dexamethasone, methylprednisolone; OC; midazolam; strong CYP3A4 inhibitors eg ketoconazole; rifampin; paroxetine.
View more drug interactions with Emend |
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Pregnancy Category (US FDA) |
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). |
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Storage |
View Emend storage conditions for details to ensure optimal shelf-life. |
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Mechanism of Action |
View Emend mechanism of action for pharmacodynamics and pharmacokinetics details. |
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