部份中文异山梨醇二硝酸酯处方资料（仅供参考）
英文名：Isosorbide Dinitrate
商品名：Nitorol
中文名：异山梨醇二硝酸酯片
生产商：卫材
药品简介
Nitorol（Isosorbide Dinitrate）是一种具有血管扩张活性的有机硝，具有血管扩张活性的有机硝酸盐。为预防和治疗冠心病引起的心绞痛发作。
ニトロール錠５mg
药物类别名称
缺血性心脏病治疗剂
批准日期：1978年２月
商標名
Nitorol
一 般 名
硝酸イソソルビド（Isosorbide Dinitrate)
化 学 名
1, 4 : 3, 6‐Dianhydro‐D‐glucitol dinitrate
分 子 式
C6H8N2O8
分子量
236.14
構 造 式
物理化学的性状
硝酸异二苯二酯是一种白色晶体或结晶粉末,没有异味,或有微闻像硝酸。
本产品n,极可溶于N-二甲基甲酰或丙酮,易溶于氯仿或甲苯、甲醇、乙醇(95)或微溶于二乙醚,几乎不溶于水。
本产品在快速加热或产生冲击时爆炸。
处理注意事项
1. 温度,当在高湿度下长期储存时,晶体可能沉积在片剂表面。
2. 本药物应存放在自动包装机中,因为此药物的内容在未包装的打开状态下观察到。 此外,避免长期包装配方。
3. 包装后,小心储存在阴凉的地方。
药用药理学
1. 减少预载荷和后载荷
在与麻醉狗的实验中,药物通过延长静脉容量血管,导致静脉反流减少,肺动脉楔形压力和左心室膨胀端压降低(减少预载荷)。通过同时延伸外周动脉,降低整体外周血管阻力(减少后负荷)。这些行动减少了心肌的氧气需求。
2. 冠状血管扩张
在麻醉狗的实验中,药物延伸了相对厚的冠状动脉(导流血管),也延伸了侧下溶血途径,以及减少冠状动脉的抵抗力,虽然冠状动脉血流的增加是轻微的,缺血性心肌, 特别是指出血液流动供应的再分配到子宫内膜下心肌,已观察到增加心肌的氧气供应。
3. CGMP生产
与KCl预,将药物添加到收缩小腿的切除冠状动脉中,cGMP的产生与冠状动脉的松弛作用成比例增加。
适应症
心绞痛、心肌梗死和其他缺血性心脏病
用法与用量
(经口)
通常成人,一次1-2片(一次5~10毫克作为硝酸等他酸盐)口服3-4次,每天。
应该注意的是,年龄,适当增加或减少,根据症状。
(舌下含片)
在狭窄的心脏病发作期间,通常成人一次1-2片(一次5~10毫克作为硝酸等子)是下语言施用。
除了在狭窄的心脏病发作期间,通常成人一次1-2片(5~10毫克作为硝酸等索苷)每天施用3-4次。
应该注意的是,年龄,适当增加或减少,根据症状。
临床表现
临床效果
表达心绞痛发作的抑制作用在心绞痛患者,增加运动能力,为改善心电图发现,该剂的有用性已观察到一般临床试验。
包装
日本药典等比德硝酸片剂
片剂
5mg: 100片 (PTP)
5mg: 500片 (瓶装)
5mg: 1,000 片 (PTP)
制造和销售
卫材株式会社
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明资料附件：http://www.info.pmda.go.jp/go/pack/2171016F1082_1_05 
Nitorol Tablets（Isosorbide dinitrate）
Nitorol Tablets 5mg（ニトロール錠5mg）
Brand name : Nitorol Tablets 5mg
　Active ingredient: Isosorbide dinitrate
　Dosage form: white tablet, diameter 6.1mm, thickness 2.6mm
　Print on wrapping: (Face) ニトロール5mg, ENR5
(Back) ENR5, Nitorol, 5mg, ニトロール
Effects of this medicine
This medicine dilates the venous and peripheral vascular systems to reduce the work load of the heart and dilates the coronary arteries to increase the oxygen supply to the heart, alleviating oxygen shortage in the heart promptly. It relieves the symptoms such as feeling of tightness in the chest or sharp chest pain due to cardiac ischemia.
It is usually used for treatment of ischemic heart disease such as angina or myocardial infarction.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reaction(itch, rash, etc.) to any medicine.
If you have hypotension, cardiogenic shock, glaucoma, anemia, head trauma, brain hemorrhage, pulmonary hypertension or cardiomyopathy.
If you are taking sildenafil citrate (Viagra, Revatio), vardenafil hydrochloride hydrate (Levitra), tadalafil (Cialis, Zalutia, Adcirca) or riociguat (Adempas).
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, take 1 to 2 tablets (5 to 10 mg as the active ingredient) at a time, 3 to 4 times a day orally or sublingually, to be adjusted depending on the disease, symptom severity or age. Strictly follow the instructions.
During angina attack: In general, for adults, take 1 to 2 tablets (5 to 10 mg as the active ingredient) at a time sublingually, to be adjusted depending on symptom severity or age. Strictly follow the instructions.
•If you miss a dose, take a dose as soon as possible if you remember that you missed a dose 6 hours or over before the next dose. If it is 6 hours or less before the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•This medicine may cause attention deficit or loss of concentration/reflexes. Avoid operating a motor vehicle or machinery.
•Use caution when consuming alcoholic beverages, since consuming too much alcohol while on this medication may cause headache, dizziness or dizziness on standing up.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include rash, headache and dizziness. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep this medicine out of the reach of children and away from direct sunlight, heat or moisture.
•If you have leftover medicines, dispose of them appropriately and do not keep any unused medicine.
Eisai Co., Ltd.External
Revised: 7/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.