部份中文替米沙坦/氢氯噻嗪处方资料（仅供参考）
商品名：Micombi Combination Tablets
英文名：Telmisartan/Hydrochlorothiazide
中文名：替米沙坦/氢氯噻嗪
生产商：安斯泰来制药
ミコンビ配合錠AP／ミコンビ配合錠BP
药用类别名称
胆汁排泄型持久性AT1受体阻滞剂/利尿剂
批准日期：2009年6月
商標名
Micombi Combination Tablets AP
Micombi Combination Tablets BP
一般名
テルミサルタン（JAN）
Telmisartan（JAN，INN）
化学名
4’-{[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl}biphenyl-2-carboxylic acid
化学構造式
raster
分子式
C33H30N4O2
分子量
514.62
性状
它是一种白色细黄色的结晶粉末。
易溶于甲酸, 不易溶于甲醇, 很易溶于乙醇 (99.5), 不易溶于水。
多态性被观察。
熔点
269°c
分布系数
日志 P = 3.2 (N-octanol/Ph-4 磷酸盐缓冲液)
一般名
ヒドロクロロチアジド（Hydrochlorothiazide）
化学名
6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
化学構造式
raster
分子式
C7H8ClN3O4S2
分子量
297.74
性状
白色的水晶或结晶性粉末, 没有气味, 味道略带苦味。 易溶于丙酮, 不易溶于乙腈, 极不溶于水或乙醇 (95), 不易溶于乙醚。 它融化成氢氧化钠测试溶液。
熔点
约 267°c (分解)
操作注意事项
由于包装后吸湿可能会使其软化, 因此应加以保存, 以避免高温和高湿。
药用药理学
1. 高血压大鼠的降压作用 (SHR)
利用男性 SHR 下的兴奋, 我检查了降压作用的情况下, 替苏拉坦的情况下, 盐酸噻嗪或两个10公斤连续口服5天。因此, 仅心灵素口服的在第5天的给药显示出最大的降压作用为36mmHg。虽然在单次给药中没有观察到明显的降压作用, 但与身来苏丹联合, 明显增强了端粒磺胺的作用, 最大降压作用为530亿汞柱。
2. 自发性高血压大鼠的利尿活性 (SHR)
用男性SHR在唤醒下, 检查后的利尿作用, 当h、氢氯噻嗪或两个10的终点连续5天口服。因此, 通过单次给药的的苏丹末端, 观察到尿量和尿电解质浓度(Na +、K + 和 c-)的显著变化。 另一方面, 单次给药液氯噻嗪为10mg/kg, 观察到尿量、Na +、K +和氯表观的电解质浓度增加。即使与替米沙坦联合使用, 观察到氢氯噻嗪的利尿活性, 底虫磺胺对氢氯噻嗪的利尿作用影响不大。
适应症
高血压
用法与用量
成人；每天一次，每次1片(40mg/7.5毫克或80mg/7.5毫克)口服为Telsulartan氢氯噻嗪。这种药物不作为高血压治疗的首选药物。
包装
片AP:100片(10片x10) PTP, 500片(10片x50) PTP, 700片(14片x50) PTP, 500片
片BP:100片(10片x10) PTP, 500片(10片x50) PTP, 700片(14片x50) PTP, 250片瓶
制造和销售
日本Beehringer Ingelheim公司
销售商
安斯泰来制药公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整资料附件：http://bij-kusuri.jp/medicine_data/mco_t/650168_2149113F1027_1_12_content.htm
Micombi Combination Tablets AP（Telmisartan/Hydrochlorothiazide，ミコンビ配合錠AP）
Brand name:Micombi Combination Tablets AP
Active ingredient:Telmisartan
Hydrochlorothiazide
Dosage form:yellowish orange tablet (diameter: ca. 8.5mm, thickness: ca. 3.4mm)Print on wrapping:(Face) Micombi 配合錠 AP, テルミサルタン 40mg ヒドロクロロチアジド 12.5mg,H4, ミコンビ AP (Back) ミコンビ配合錠 AP, BoehringerIngelheim,astellas,テルミサルタン 40mg ヒドロクロロチアジド 12.5mg, 高血圧治療剤
Effects of this medicine
Micombi is a combination drug of an angiotensin receptor blocker (ARB) and diuretic: the ARB inhibitsvasoconstriction caused by angiotensin II in vascular smooth muscle to lower blood pressure and the diureticincreases urine output via inhibition of sodium and water reabsorption in the kidney to lower blood pressure.
Usually, this medicine is used in the treatment of hypertension.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have a hepatic disorder, poor bile secretion, or anuria, are on dialysis, or have acute renal failure, reducedsodium and/or potassium in body fluid, or diabetes mellitus.
If you are pregnant, possibly pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinaleffects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
・Your dosing schedule prescribed by your doctor is<< to be written by a healthcare professional>>
・In general, for adults, take 1 tablet, once daily. Strictly follow the instructions.
・To avoid possible effects of food, always take the drug at regular dosing schedule, that is, before every meal or afterevery meal.
・For patients taking the medicine before meals, if you miss a dose, take as soon as possible. If it is almost time for thenext dose, skip the missed dose and continue your regular dosing schedule.
For patients taking the medicine after meals, if you miss a dose, take as soon as possible after taking a snack. Youshould never take two doses at one time.
・If you accidentally take more than your prescribed dose, you may feel dizzy due to hypotension. In such cases,consult with your doctor or pharmacist immediately.
・Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
・Use caution when driving, operating machinery, working at high places or engaging in other hazardous activities.
The medicine may cause dizziness and a decrease in blood pressure.
・Avoid or be careful when drinking alcohol. It may enhance orthostatic hypotension (lightheadedness).
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include postural vertigo, dizziness, photosensitivity, hypotension,frequent urination, itching, hives, erythema, breathing difficulty, facial flush and rash. If any of these symptomsoccur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicatedin brackets. If any of these symptoms occur, stop taking this medicine and see your doctorimmediately.
・swelling of the eyelids, lips, tongue, or throat; breathing difficulty, decrease in blood pressure [angioedema,anaphylaxis]
・numbness of the hands and lips, muscle weakness, paralysis of limbs [hyperkalemia]
・cold sensation, vomiting, faint [shock, syncope, loss of consciousness]lassitude, hunger, cold sweat [hypoglycemia]
・a decrease in urine volume, edema, general fatigue [renal impairment]
・dry cough, fever, breathing difficulty (shortness of breath on exertion) [interstitial pneumonia]
・lassitude, muscle pain, brown urine [rhabdomyolysis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with yourdoctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
・Keep out of the reach of children. Store away from heat, moisture and direct sunlight.
・Discard unused medicine
Internal
Revised: 04/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approvaldetails may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It isimportant to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response,patients should understand their medication and cooperate with the treatment.