| 简介：
部份中文阿拉普利处方资料（仅供参考）
商品名：CETAPRIL
英文名：Alacepril
中文名：阿拉普利片
生产商：住友制药
セタプリル錠12.5mg/セタプリル錠25mg/セタプリル錠50mg
药用分类名称
持久性ACE抑制降压剂
批准日期：1988年5月
商標名
CETAPRIL
一般名
アラセプリル Alacepril
化学名
(2S)-2-{(2S)-1-[(2S)-3-(Acetylsulfanyl)-2-methylpropanoyl]pyrrolidine-2-carbonyl}amino-3-phenylpropanoic acid
分子式
C20H26N2O5S
分子量
406.50
融点
153〜157℃
分配係数
0.073(クロロホルム/水系溶媒、pH7.0)
性状
它是白色晶体或结晶粉末。容易溶于甲醇，容易溶于乙醇（95），不溶于水。溶解在氢氧化钠试液中。
药效药理
1. 操作机制
该制剂通过抑制在大鼠体内试验中的ACE（激酶II）来抑制升压系统（肾素血管紧张素-阿多斯特龙系统），并增强降压系统（卡利克莱因奎宁前列腺素系统），表达降压作用。此外，脱乙酰阿拉塞塞里尔很好地迁移到动脉血管壁，因为它抑制外周交感神经系统，被认为参与剂的降压作用和持久性。
2. 降压效果
在针对原发性高血压患者的临床药理学测试中，该制剂在与卡普托普利相同的重量给药中表现出相同的降压效果，并表现出更长的作用持久性。
适应症
原发性高血压，肾高血压
用法与用量
通常，成人每天将25-75mg作为阿拉塞普里尔口服1至2次。 年龄，根据症状适当增加或减少。
此外，即使在严重的情况下，每天的最大剂量为100mg。
包装
片剂
12.5mg：[PTP] 100片（10片x10）
25mg：[PTP] 100片（10片x10），500片（10 片×50）1000片（10 片×100）1400片（14片x100）[瓶装] 500 片
50mg：[PTP] 140 片（14片x10）
制造供应商
大日本住友制药株式会社
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明资料附件：
http://www.info.pmda.go.jp/go/pack/2144003F1029_1_16/?view=frame&style=SGML&lang=ja
CETAPRIL Tablets（Alacepril）
CETAPRIL Tablets 50mg（セタプリル錠50mg）
Brand name : CETAPRIL Tablets 50mg
Active ingredient: Alacepril
Dosage form: white tablet, major axis: 11.6mm, minor axis: 5.8mm, thickness: 3.2mm
Print on wrapping: セタプリル錠, 50mg, P323
Effects of this medicine
This medicine blocks angiotensin-converting enzyme in order to suppress vasopressor system and to enhance depressor system, and consequently to lower blood pressure.
It is usually used to treat essential/renal hypertension.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you ever had angioedema.
If you are receiving apheresis and dialysis.
If you are a patient with diabetes mellitus.
•If you are pregnant, breastfeeding or possibly pregnant.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is ((to be written by a healthcare professional))
•In general, for adults, take 1 to 3 tablets (25 to 75mg of the active ingredient) in 1 to 2 divided doses a day. The dose may be adjusted according to your age and symptoms. The maximum dose is 4 tablets (100mg) a day. Strictly follow the instructions.
•If you miss a dose, take the missed dose. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally took more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•You may feel dizziness/lightheadedness due to decreased blood pressure. Pay close attention performing dangerous operation such as driving a car, operating machinery or working at height.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include cough, rash, dizziness, nausea, lightheadedness, general malaise, anemia, itch and taste abnormality. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•respiratory distress, swollen eyelids/lips/tongue, hives [angioedema]
•sore throat, headache, high fever with chills or shiver [agranulocytosis]
•blister of various sizes appearing on the skin/mucous membrane, breakable blister, severe itchiness throughout the body [pemphigus-like symptoms]
•numbness in the limbs/lips, muscle weakness, paralyzed limbs [hyperkalemia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
Sumitomo Dainippon Pharma Co.,Ltd.Internal
Revised: 2/2016
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
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