部份中文卡托普利处方资料（仅供参考）
英文名：Captopril
商品名：CAPTORIL-R
中文名：卡托普利胶囊
生产商：第一三共
カプトリル−Ｒカプセル18.75mg
药效分类名称
肾素-血管紧张素类降压药/长效配方
批准日期：2008年12月
商標名
CAPTORIL-R CAPSULES
一般名
カプトプリル(Captopril)
化学名
(2S )-1-[(2S )-2-Methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
分子式
C9H15NO3S
分子量
217.29
構造式
性状
它是白色晶体或结晶性粉末。
极易溶于甲醇，极易溶于乙醇（99.5），微溶于水。
分配系数
见分配系数表
有关有效成分的理化检查结果表
分配系数

Pow =（正辛醇相卡托普利浓度/水相卡托普利浓度）
药效药理
托普利抑制血管紧张素转化酶并抑制血管紧张素II的产生，从而扩大外周血管，降低总的外周血管阻力并显示降压作用，同时抑制醛固酮分泌和轻度钠排泄作用。代表
（1）血管紧张素转换酶的抑制作用
卡托普利已显示出竞争性抑制从兔肺中纯化的血管紧张素转化酶，并通过口服给药抑制由血管紧张素I引起的血压升高。
（2）降压作用
1）卡托普利通过口服降低自发性高血压大鼠和肾血管性高血压大鼠的血压，但不影响正常大鼠的血压。
2）即使长期连续口服（大鼠），降压作用也不能耐受卡托普利。另外，即使连续给药后停药，血压也恢复到原来的水平，未观察到反弹现象（大鼠）。
3）卡托普利根据剂量引起血压降低和心输出量增加，总外周阻力降低，但心率无明显变化。另外，即使血压降低，它也不会减少器官的血流量，相反会显着增加肾和脑的血流量（大鼠）。
4）长期服用卡托普利可改善因高血压引起的心脏肥大并延长寿命（大鼠）。
（3）对血压日变化的影响
在患有原发性高血压的患者中，每天服用1粒Captolyl-R胶囊后，在服用4小时后显示出最大的降压作用，这种作用持续到10至12小时后。另外，最大和最小血压均显着降低，并且对血压的标准偏差和最大每日波动范围几乎没有影响。
适应症
原发性高血压，肾性高血压
用法与用量
原发性高血压，肾性高血压
成人通常的剂量是每天口服两次1至2粒胶囊（卡托普利为37.5至75毫克）。剂量可以根据年龄和症状进行调整。但是，在患有严重原发性高血压和肾性高血压的患者中，理想的是每天一次或两次（胶囊剂量为18.75-37.5 mg卡托普利）开始一次给药。
包装
胶囊
18.75mg：（PTP）100胶囊1,000胶囊
（瓶）500胶囊
制造商
第一三共Espha有限公司
销售提携
第一三共株式会社
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明资料附件：
https://www.info.pmda.go.jp/go/pack/2144001N1059_3_05/
CAPTORIL-R CAPSULES（Captopril,カプトリル-Rカプセル18.75mg）
Brand name : CAPTORIL-R CAPSULES 18.75mg
　Active ingredient: Captopril
　Dosage form: white capsule with reddish brown belt, major axis : 15.8 mm, minor axis : 5.8 mm
　Print on wrapping: (front) カプトリル-Rカプセル18.75mg, 第一三共エスファ, カプトリル-R, 18.75mg, 271, (back) CAPTORIL-R 18.75mg, 血圧降下薬, カプトリル-R, 18.75mg
Effects of this medicine
This medicine inhibits angiotensin-converting enzyme to suppress production of angiotensin II, and consequently shows antihypertensive action by dilating peripheral blood vessels and decreasing vascular resistance. It also suppresses secretion of aldosterone to show sodium excretory effect.
It is usually used in the treatment of essential hypertension and renal hypertension.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions(itch, rash, etc.)to any medicines.
If you have a history with angioedema.
If you are receiving apheresis or hemodialysis.
•If you are pregnant, possibly pregnant or breastfeeding.
•If you are taking any other medicinal products.(Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is<<to be written by a healthcare professional>>
•In general, for adults, take 1 to 2 capsules (18.75 to 37.5 mg of the active ingredient) at a time, twice daily. The dosage may be adjusted according to the diseases, age or symptoms. In the treatment of severe essential hypertension and renal hypertension, it is desirable to start taking 1 capsule (18.75 mg) at a time, once or twice daily. Strictly follow the instructions.
•If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Dizziness and lightheadedness may occur due to decreased blood pressure. Pay attention to performing dangerous operations such as driving a car or working at heights.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include cough, rash, itch, hives, photosensitivity, anemia, taste abnormality and jaundice. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•respiratory distress; swelling in the face, tongue, glottis or larynx; hives[angioedema]
•general malaise, headache, throat pain, gum bleeding, subcutaneous bleeding[pancytopenia, agranulocytosis]
•decreased urine output, edema, loss of appetite [acute renal failure, nephrotic syndrome]
•numbness in the limbs and lips, muscular weakness, paralysis in the limbs [hyperkalemia]
•blisters appearing on the skin, severe itchiness throughout the body [pemphigus like symptoms]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
DAIICHI SANKYO ESPHA CO., LTD.Internal
Revised: 3/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions(risks)as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.