部份中文缬沙坦处方资料（仅供参考）
英文名：Valsartan
商标名：DIOVAN OD
中文名：缬沙坦口腔崩解片
生产商：诺华制药
ディオバンOD錠20mg/ディオバンOD錠40mg/ディオバンOD錠80mg/ディオバンOD錠160mg
药效分类名称
选择性AT1受体阻滞剂
批准日期：2013年6月
構造式
一般名
バルサルタン（Valsartan）
化学名
（2S）-3-Methyl-2-（N-｛［2'-（1H-tetrazol-5-yl）biphenyl-4-yl］methyl｝pentanamido）butanoic acid
分子式
C24H29N5O3
分子量
435.52
性状
白色粉末。它极易溶于甲醇、乙醇（99.5），几乎不溶于水。
处理注意事项
由于该剂具有吸湿性，因此应保留为PTP板材（不适合自动包装机）。
药效药理
缬沙坦与AT1受体结合，该受体是血管紧张素II受体的亚型，通过对抗血管紧张素II作为升压系统来表现出降压作用。
（1）降压作用
1）Valsartan通过口服给药，肾高血压大鼠，自然发育高血压大鼠（SHR），但剂量依赖性降低耗尽的马莫塞特的血压，不影响DOCA/salt型高血压大鼠的血压。
2）Valsartan连续（4周）口服后休息，肾高血压大鼠，在自发性高血压大鼠（SHR）中，没有出现反弹现象。
3）Valsartan通过长期连续（44周）口服给药，持续降低中风易发性自发性高血压大鼠 （SHR-SP） 的血压，但心率没有显著变化。此外，通过长期连续（48周）口服给药，抑制主动脉血管的增厚。
（2）血液动力学及其对心脏的影响
1）通过口服给药，在不降低自然发育高血压大鼠（SHR）的器官血流量的情况下，肾血流量显著增加。
2） 缬沙坦通过连续（4周）口服给药抑制缺血性心力衰竭模型大鼠的心脏肥大，通过长期连续（48周）口服给药抑制中风易发性自然发病高血压大鼠（SHR-SP）的心脏肥大。
（3）对肾功能的影响
Valsartan通过连续口服给药，抑制肾损伤恶化的肾部分去除大鼠（6周）和中风易发性自然发病高血压大鼠（SHR-SP）（32周，40周，44周）。
（4）作用机制
Valsartan选择性地结合到AT1受体，这是血管紧张素II受体的亚型，在受体水平上与血管紧张素II 竞争对抗，作为升压系统。
1） 在大鼠主动脉平滑肌中，Valsartan竞争地抑制血管紧张素II与AT1受体的结合。此外，它对AT1受体以外的受体几乎没有亲和力。
2） 在兔子切除的主动脉环标本中，诺拉肾上腺素对血清素和氯化钾的收缩没有抑制作用，具体抑制血管紧张素II的收缩。
3）Valsartan通过口服给药，在脊髓破坏大鼠中未表现出交感刺激和诺拉肾上腺素对升压反应的抑制作用，具体抑制血管紧张素II的升压反应。
4）Valsartan显著抑制牛肾上腺球状层细胞中血管紧张素II产生醛固酮。
5）缬沙坦不影响人类支气管上皮细胞的ACE活性和布拉迪基宁降解。
适应症
高血压
用法与用量
通常，成人每天口服40-80毫克作为缬沙坦。另外，年龄，但根据症状适当增加或减少，可以增加到每天160毫克。
通常，对于6岁以上的儿童，作为缬沙坦，如果体重小于35公斤，20毫克，如果体重超过35公斤，每天口服40毫克一次。另外，年龄，体重，根据症状增加或减少。然而，每天的最高剂量，如果重量小于35公斤，为40mg。
包装
口腔崩解片
20mg 140 片 （PTP）
40mg 140 片 （PTP）700 片（PTP）
80mg 140 片 （PTP）500 片（PTP） 700片（PTP）
160mg 100片 （PTP）140 片（PTP）
制造与销售
诺华制药有限公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明书附件：
https://www.info.pmda.go.jp/go/pack/2149041F5026_1_10/?view=frame&style=SGML&lang=ja
DIOVAN OD Tablets 160mg（Valsartan，ディオバンOD錠160mg）
Brand name : DIOVAN OD Tablets 160mg
　Active ingredient: Valsartan
　Dosage form: white tablet, major axis: 15.0 mm, minor axis: 8.0 mm, thickness: 6.1 mm
　Print on wrapping: ディオバンOD160mg, DIOVAN OD160mg, NV144
Effects of this medicine
This medicine binds to angiotensin II receptor produced in the body, and inhibits the hypertensive activity of angiotensin II by blocking its vasoconstrictive effects. It consequently lowers blood pressure in patients with hypertension.
It is usually used to treat hypertension.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions(itch, rash, etc.) to any medicines.
If you are a patient with diabetes mellitus, renal disorder, hyperkalemia or schedule of surgery.
If you are a patient on hemodialysis or low-salt diet.
If you are pregnant, possibly pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule(How to take this medicine)
Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
For adults: In general, take 40 to 80 mg of the active ingredient at a time, once a day. The dosage should be adjusted according to the age or symptoms. However, daily dose may be increased to 160 mg.
For children aged 6 years and older: In general, for children weighing less than 35 kg, take 20 mg of the active ingredient at a time, once a day. For children weighing 35 kg and more, take 40 mg of the active ingredient at a time, once a day. The dosage should be adjusted according to the age, body weight or symptoms. However, for children weighing less than 35 kg, the maximum daily dose is restricted to 40 mg.
This product contains 160 mg of the active ingredient in a tablet. Strictly follow the instructions.
You can take the medicine without water. Soak the tablet with saliva on your tongue and crush it lightly with your tongue, then swallow it with saliva. You can also take it with water or warm water as you do an ordinary tablet.However, you should never take the tablet without water when you are in a lying position.
Tablets may be cracked or chipped. However, the quality of the tablet is unaffected. Take the entire prescribed amount of the medicine including the fragments.
If you missed a dose, take a dose as soon as possible. However, if it is 8 hours or less before the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
The medicine may cause dizziness or light-headedness since the blood pressure is decreased. Pay attention when you work at heights, drive a car or operate dangerous machinery.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include dizziness, headache, palpitation, abdominal pain, dry cough, nausea, malaise, rash, hypotension, itch and photosensitivity.If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
swelling in face/lip/throat/tongue, breathlessness[angioedema]
loss of appetite, general malaise, yellowness in the skin and/or the white of the eye [hepatitis]
decrease of urine output, swelling in limbs, loss of appetite[renal failure]
loss of consciousness, vomiting, cold feeling [shock, faint, loss of consciousness]
muscle weakness, numbness of limbs or lips, paralysis in limbs[hyperkalemia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep out of the reach of children. Store away from direct sunlight, heat and moisture. Keep in press-through package(PTP)sheet just before taking.
Discard the remainder. Do not store them.
Novartis Pharma K.K.Internal
Revised: 3/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies(benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.