部份中文瑞舒伐他汀处方资料（仅供参考）
商品名：Crestor
英文名：Rosuvastatin
中文名：瑞舒伐他汀
药理作用
1.降血脂作用
罗伐他汀降血脂作用明显, 一般他汀类药物降低低密度脂蛋白胆固醇(LDL-C)的水平为17% ～ 54%。而罗伐他汀的Ⅱ期临床试验结果表明, 剂量为80mg时, 其降LDL-C达 65%, 是目前他汀类药物中疗效最好的。罗伐他汀可以增加 LDL受体的数量。在人肝细胞瘤中, 罗伐他汀提高LDL受体的mRNA量比普伐他汀约多10倍。
2.对肝细胞的选择性作用
源于肝细胞的胆固醇是形成血胆固醇的主要原因, 而源于非肝细胞的胆固醇是正常细胞所必需的。 罗伐他汀的主要作用部位是肝脏, 从抑制固醇合成看,该药对大鼠肝脏的选择性要比对外周组织的选择性高, 并且比普伐他汀或辛伐他汀对肝组织的选择性要高。通过主动吸收过程, 罗伐他汀被吸收到肝细胞中, 它在大鼠肝细胞中对胆固醇的抑制效力比在成纤维细胞中高 1000倍。
3.抗动脉粥样硬化作用
罗伐他汀能降低血脂 , 减少脂质浸润和泡沫细胞形成, 对延迟动脉粥样硬化有利;该药还可通过阻断羟甲基戊二酸通路, 特别是抑制类异戊二烯代谢产物的形成而抑制平滑肌细胞增殖和促进细胞凋亡而稳定粥样斑块,延缓动脉粥样硬化的发生、发展。
适应证
用于原发性高胆固醇血症、混合性脂质失调的治疗
用法用量
高胆固醇血症及混合型血脂障碍(高脂蛋白血症Ⅱa和Ⅱb型)：口服，推荐起始剂量10mg，常用剂量5～40mg，每日1次，饭前或饭后服用。
纯合子家族性高胆固醇血症：口服，推荐起始剂量20mg，每日1次，最大日剂量40mg。
亚裔患者：推荐开始剂量5mg，每日1次，剂量可根据情况调整为每日5mg、10mg、20mg。正在服用环孢素的患者：推荐剂量5mg，每日1次。
严重肾功能不全患者(肌酐清除率<30ml/min)：推荐剂量5mg，每日1次，最大日剂量10mg。
禁忌证
1.对本品过敏患者禁用。
2.活动性肝病患者禁用。
3.肌病患者禁用。
4.妊娠毒性分级为X，孕妇禁用。
注意事项
1.过度饮酒者慎用。
2.有肝病史的患者慎用。
3.本品在大鼠乳汁中的浓度为血浆药物浓度的3倍，哺乳期妇女慎用。
4.服药前与服药期间接受低胆固醇饮食，服用剂量因人因治疗目标而异。
5.在使用本品前及治疗3个月内进行肝功能检查，若血清转氨酶高于正常值3倍时应停用本品或减量。
6.若有不明原因肌痛、肌无力发生时或怀疑为肌病应立即停用本品。
7.在不同性别和年龄人群中使用的药动学无差异。8.8岁以下儿童用药安全性尚无资料。
9.轻、中度肾功能不全对本品血浆浓度无影响，重度肾功能不全者血药浓度为正常者的3倍，严重肝功能不全者血药浓度可达正常者的2倍。
10.发生药物过量采用支持治疗，本品不易通过透析清除。
注：使用者以完整说明书为准：https://www.medicines.org.uk/emc/medicine/11976
Crestor 5mg, 10mg, 20mg and 40mg film-coated tablets
Important Safety Information About CRESTOR Tablets
CRESTOR is not right for everyone. Do not take CRESTOR if you are nursing, pregnant or may become pregnant; have liver problems; or have had an allergic reaction to CRESTOR
Your doctor should do blood tests to check your liver before starting treatment and if you have symptoms of liver problems while taking CRESTOR
Call your doctor right away if you:
Have unexplained muscle pain or weakness, especially with fever
Have muscle problems that do not go away even after your doctor told you to stop taking CRESTOR
Feel unusually tired
Have loss of appetite, upper belly pain, dark urine, or yellowing of skin or eyes.
These could be signs of rare but serious side effects
Elevated blood sugar levels have been reported with statins, including CRESTOR
Side effects: The most common side effects may include headache, muscle aches, abdominal pain, weakness, and nausea. Memory loss and confusion have also been reported with statins, including CRESTOR
Tell your doctor and pharmacist about other medicines you are taking
Talk to your doctor about prescription CRESTOR.
Approved Uses for CRESTOR
When diet and exercise alone aren't enough to lower cholesterol, adding CRESTOR can help.
In adults, CRESTOR is prescribed along with diet to lower high cholesterol and to slow plaque buildup in arteries as part of a treatment plan to lower cholesterol to goal.