部份中文硫酸氯吡格雷/阿司匹林处方资料（仅供参考）
英文名：Clopidogrel Sulfate/Aspirin
商品名：ComPlavin Combination Tablets
中文名：硫酸氯吡格雷/阿司匹林配合片
生产商：赛诺菲公司
药品简介
ComPlavin（Clopidogrel Sulfate/Aspirin）是一种抗血小板聚集药。用于预防正在使用氯吡格雷和阿司匹林的成人患者的动脉粥样硬化及用于以下症状的延续治疗：非ST段抬高急性冠状动脉综合征（不稳定型心绞痛或非Q波心肌梗死患者）包括接受冠状动脉支架手术后的患者；用药物治疗的ST段抬高的急性心肌梗死病人的溶栓治疗。
コンプラビン配合錠
药效分类名称
抗血小板药
批准日期：2013年11月
商標名
ComPlavin
1. 硫酸氯吡格雷
一般名
クロピドグレル硫酸塩（Clopidogrel Sulfate）
化学名
Methyl（2S）-2-（2-chlorophenyl）-2-［6, 7-dihydrothieno［3, 2-c］pyridin-5（4H）-yl］acetate monosulfate
分子式
C16H16ClNO2S・H2SO4
分子量
419.90
構造式
融　点
約177℃（分解）
性　状
该产品为白色至微黄色白色结晶性粉末或粉末。
该产品易溶于水或甲醇，微溶于乙醇（99.5）。
由于光照，该产品逐渐变成褐色。
该产品具有结晶多态性。
2. 阿司匹林
一般名
アスピリン（Aspirin）
化学名
2-Acetoxybenzoic acid
分子式
C9H8O4
分子量
180.16
構造式
融　点
約136℃
性　状
该产品为白色晶体，谷粒或粉末，无臭，微酸。
该产品易溶于乙醇（95）或丙酮，微溶于二乙醚，微溶于水。
该产物可溶于氢氧化钠测试溶液或碳酸钠测试溶液。
该产品在潮湿的空气中逐渐水解为水杨酸和乙酸。
药效药理
1.药理作用
（1）硫酸氯吡格雷对体外的血小板凝集没有抑制作用，口服后在肝脏中代谢成为活性代谢产物，并通过ADP刺激引起的血小板活化而抑制血小板凝集。在大鼠中，还观察到胶原蛋白和低浓度凝血酶对血小板聚集的抑制作用。
（2）硫酸氯吡格雷用于脑中动脉血栓形成模型（大鼠），动静脉分流模型（大鼠），冠状动脉周期性血流量减少模型（狗），颈动脉球囊内皮损伤模型（兔子）和支架置入。在静脉分流模型（兔）中，血栓形成受到抑制，而在大脑中动脉脑血栓形成模型中，基于血栓形成的抑制，梗塞面积减小。当与阿司匹林联合使用时，对颈动脉球囊内皮损伤模型和带支架的动静脉分流模型的血栓形成抑制作用增强。
2.作用机理
（1）硫酸氯吡格雷的活性代谢产物不可逆地作用于血小板的ADP受体亚型P2Y1227），抑制ADP的结合，从而抑制基于血小板活化的血小板凝集。
（2）阿司匹林通过抑制环氧合酶1抑制血栓烷A2的合成并抑制血小板聚集。
适应症
经皮冠状动脉成形术（PCI）适用于以下缺血性心脏病
急性冠状动脉综合征（不稳定型心绞痛，非ST抬高型心肌梗塞，ST抬高型心肌梗塞）
稳定型心绞痛，老年心肌梗塞
用法与用量
通常，对于成年人，每天口服1片（75毫克氯吡格雷和100毫克阿司匹林）。
包装
100錠［10錠（PTP）×10］
500錠［10錠（PTP）×50］
生产与销售
赛诺菲有限公司
注：以上中文处方资料不够完整，使用者以原处方为准。
完整说明资料附件：
https://www.info.pmda.go.jp/go/pack/3399101F1021_1_14/
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ComPlavin Combination Tablets（Clopidogrel Sulfate/Aspirin，コンプラビン配合錠）
Brand name:ComPlavin Combination Tablets
　Active ingredient:Clopidogrel Salfate
  Aspirin
　Dosage form: white to pale yellow tablet, diameter: 11mm, thickness: 6mm
　Print on wrapping: コンプラビン配合錠 ComPlavin saCA
Effects of this medicine
This medicine is a combination of the two active ingredients and inhibits platelet aggregation based on platelet activation, suppresses clot formation and prevents blockage of blood vessels.
It is usually used for acute coronary syndrome, stable angina pectoris and old myocardial infarction for which percutaneous coronary intervention is indicated.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions(asthma, itch, rash, etc.)to any medicines.
•If you have bleeding, pain or tenderness in the solar plexus, heartburn, belching, nausea, vomiting, hematemesis and melena.
•If you are going to undergo dental extraction or surgery.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products.(Some medicines may interact to enhance or diminish medicinal effects.Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, take 75 mg as clopidogrel and 100 mg as aspirin once a day from the date of first administration.Strictly follow the instructions.
•If you miss a dose, take the missed dose as soon as possible. You should never take two doses at one time. in general, for adults, take this medicine once a day. Strictly follow the instructions. Avoid taking this medicine on an empty stomach. Take this medicine as it is without breaking, chewing and crunching.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
• Possible adverse effects of this medicine
The most commonly reported adverse reactions include bleeding tendency including subcutaneous bleeding, nausea/vomiting and loss of appetite. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•sudden severe headache, nausea/vomiting, one-sided face or limbs paralysis[intracranial bleeding, subdural hematoma]
•melena (black stool, bloody stool), hematemesis, vision disorder, joint pain[hematemesis, melena, gastrointestinal bleeding, ocular fundus bleeding, joint hematoma, lung bleeding]
•severe fatigue/malaise, loss of appetite, yellow discoloration of the white of the eyes/the skin[liver dysfunction, jaundice]
•malaise, loss of appetite, purpura, disturbed consciousness[thrombotic thrombocytopenic purpura]
•sore throat, headache/feeling of dull headache, ear ringing[thrombocytopenia, leukopenia, agranulocytosis, pancytopenia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep this medicine out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.