Drug Class Description
DPP-4 Inhibitor
Generic Name
Sitagliptin
Drug Description
Film-coated tablet (tablet).Round, beige film-coated tablet with “277” on one side.
Presentation
Each tablet contains sitagliptin phosphate monohydrate, equivalent to 100 mg sitagliptin.
Indications
JANUVIA is indicated in patients with type 2 diabetes mellitus to improve glycaemic control in combination with metformin when diet and exercise, plus metformin do not provide adequate glycaemic control. For patients with type 2 diabetes mellitus in whom use of a PPAR? agonist (i.e. a thiazolidinedione) is appropriate, JANUVIA is indicated in combination with the PPAR? agonist when diet and exercise plus the PPAR? agonist alone, do not provide adequate glycaemic control.
Adult Dosage
The dose of JANUVIA is 100 mg once daily. The dosage of metformin or PPARγ agonist should be maintained, and sitagliptin administered concomitantly.
When JANUVIA is used in combination with a sulphonylurea, a lower dose of the sulphonylurea may be considered to reduce the risk of hypoglycaemia.
If a dose of JANUVIA is missed, it should be taken as soon as the patient remembers. A double dose should not be taken on the same day.
JANUVIA can be taken with or without food.
Patients with renal insufficiency
