What is it and how is it used?
Integrilin is an inhibitor of platelet aggregation. This means that it helps to prevent blood clots from forming.
It is used in adults with manifestation of severe coronary insufficiency defined as spontaneous and recent chest pain with electrocardiographic abnormalities or biological changes. It is usually given with aspirin and unfractionated heparin.
What do you have to consider before using it?
You must not be given Integrilin:
Please tell your doctor if you have had any of these conditions. If you have any questions, ask your doctor or hospital pharmacist.
Take special care with Integrilin:
Taking other medicines
To avoid the possibility of interactions with other medicinal products please tell your doctor or hospital pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Particularly:
If you are breast-feeding a baby, breast-feeding should be interrupted during the treatment period.
How is it used?
Integrilin is given into the vein by direct injection followed by an infusion (drip solution). The dose given is based on your weight. The recommended dose is 180 microgram/kg administered as a bolus (rapid intravenous injection), followed by an infusion (drip solution) of 2 microgram/kg/minute for up to 72 hours. If you have kidney disease, the infusion dose may be reduced to 1 microgram/kg/minute.
If percutaneous coronary intervention (PCI) is performed during Integrilin therapy, the intravenous solution may be continued for up to 96 hours.
You must also be given doses of aspirin (aspirin) and heparin (if not contraindicated in your case).
If you have any further questions on the use of this product, ask your doctor or hospital pharmacist.
What are possible side effects?
Like all medicines, Integrilin can cause side effects, although not everybody gets them.
Very common side effects These may affect more than 1 in 10 people
Common side effects These may affect up to 1 in 10 people
Uncommon side effects These may affect up to 1 in 100 people
Very rare side effects These may affect up to 1 in 10,000 people
If you notice any signs of bleeding, notify your doctor or nurse immediately. Very rarely, bleeding has become severe and even fatal. Safety measures to prevent this from happening include blood tests and careful checking by the healthcare professionals taking care of you.
If you develop severe allergic reaction or hives, notify your doctor or nurse immediately.
Other events that may occur in patients, who require this type of treatment, include those that are related to the condition you are having treated, such as rapid or irregular heartbeat, low blood pressure, shock or cardiac arrest.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist .
How should it be stored?
Keep out of the reach and sight of children
Do not use after the expiry date (EXP) stated on the package and the vial. The expiry date refers to the last day of that month.
Store in a refrigerator (2°C – 8°C).
Keep the vial in the outer package in order to protect from light. However, protection of Integrilin solution from light is not necessary during administration.
Before using, the vial contents should be inspected.
Integrilin should not be used if it is noticed that particulate matter or discoloration is present.
Any unused material after opening should be discarded.
