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Drug Class Description
Coumarin anticoagulants.
Generic Name
Generic Monitor international normalised ratio (INR) on a regular basis.
Drug Description
Tablets.
Presentation
Tablets, scored, warfarin sodium 1mg (brown), 3mg (blue), 5mg (pink). Available from APS, Cox, Hillcross, Lagap, Norton, Regent.
Indications
Thromboembolic conditions.
Adult Dosage
Initially 10mg daily, adjust daily according to INR.
Contra Indications
Haemorrhagic conditions. Pregnancy. Peptic ulcer, severe hypertension, bacterial endocarditis.
Special Precautions
Impaired renal or hepatic function. Within 24 hours of surgery or labour. Weight changes, acute illness, vitamin K deficiency.
Interactions
Aspirin, NSAIDs, oral hypoglycaemics, sulphonamides, amiodarone, quinidine, propafenone, antibiotics (including rifamycins, cefamandole (cephamandole), chloramphenicol, ciprofloxacin, co-trimoxazole, erythromycin, metronidazole, ofloxacin, sulphonamides), antifungals, antivirals, phenformin, cimetidine, drugs affecting liver enzymes, corticosteroids, imidazole antifungals, tamoxifen. Alcohol. Anabolic steroids, colestyramine (cholestyramine), antiepileptics, simvastatin, thyroxine (levothyroxine), vitamin K.
Adverse Reactions
Haemorrhage. Alopecia, rash, diarrhoea, fall in haematocrit. Skin necrosis, jaundice, hepatic dysfunction. Nausea, vomiting, pancreatitis.
Drug Availability
(POM)
Updated
17 June 2009 |
