For doctors
What is it and how is it used?
SUTENT is a medicine used to treat cancer by preventing the activity of a special group of proteins which are known to be involved in the growth and spread of cancer cells.

SUTENT will only be prescribed to you by a doctor with experienced in the use of anti-cancer medicinal products.

Gastrointestinal stromal tumour (GIST)
SUTENT is indicated for the treatment of unresectable and/or metastatic malignantgastrointestinal stromal tumour (GIST) in adults after failure of imatinib mesilate treatment due to resistance or intolerance. GIST is a cancer of the stomach and bowels, originating from uncontrolled cell growth of the supporting tissues of these organs. SUTENT inhibits the growth of these cells.

Metastatic renal cell carcinoma (MRCC)
SUTENT is indicated for the treatment of advanced metastatic renal cell carcinoma (MRCC) in adults. MRCC is a form of kidney cancer that involves cancerous changes in the cells of the renal tubule.

Pancreatic neuroendocrine tumours (pNET)
SUTENT is indicated for the treatment of unresectable or metastatic, well-differentiated pancreatic neuroendocrine tumours with disease progression in adults. pNET is a rare cancer originating in the hormone-secreting cells of the pancreas.
Experience with SUTENT as first-line treatment is limited.

If you have any questions about how SUTENT works or why this medicine has been prescribed for you, ask your doctor.

What do you have to consider before using it?
Follow all your doctor’s instructions carefully, even if they differ from the general information contained in this leaflet.

Do not take SUTENT

Before you take SUTENT or while you are being treated with SUTENT:
You may be advised to have a dental check-up before you start treatment with SUTENT.

Take special care with SUTENT

Tell your doctor if you develop any of the following signs and symptoms of liver problems during SUTENT treatment: itching, -yellow eyes or skin, dark urine, and -pain or discomfort in the right upper stomach area.
Your doctor should do blood tests to check your liver function before and during treatment with Sutent, and as clinically indicated.

Before taking SUTENT
Tell your doctor if you need to undergo surgery.

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription even those not prescribed.

Some medicines can affect the levels of SUTENT in your body. You should inform your doctor if you are taking medicines containing the following active substances:
ketoconazole, itraconazole – used to treat fungal infections
erythromycin, clarithromycin, rifampicin – medicines used to treat infections ritonavir – medicines used to treat HIV
dexamethasone – a corticosteroid used for various conditions
phenytoin, carbamazepine phenobarbital – treatments for epilepsy and other conditions herbal preparations containing St. John’s Wort (Hypericum perforatum) – used to treat depression and anxiety

Taking SUTENT with food and drink
SUTENT can be taken with or without food; however, you should avoid drinking grapefruit juice while on treatment with SUTENT.

Pregnancy and breast-feeding
If you are pregnant or think you may be, tell your doctor.
SUTENT is not to be used during pregnancy unless clearly n