Drug Class Description
Statins (HMG CoA reductase inhibitors).
Generic Name
Simvastatin
Drug Description
10 mg: peach oval f-c tablet marked ZOCOR 10. 20 mg: tan oval f-c tablet marked ZOCOR 20. 40 mg: red oval f-c tablet marked MSD 749. 80mg: red capsule-shaped film- coated tablets marked 543 and 80.
Presentation
The peach-coloured, oval-shaped tablets marked 'MSD 735' contain 10 mg simvastatin. The tan-coloured, oval-shaped tablets marked 'MSD 740' contain 20 mg simvastatin. The brick-red coloured, oval-shaped tablets marked 'MSD 749' contain 40 mg simvastatin. The brick-red coloured, capsule-shaped tablets marked '543' on one side and '80' on the other contain 80 mg simvastatin
Indications
Hypercholesterolaemia Treatment of primary hypercholesterolaemia or mixed dyslipidaemia, as an adjunct to diet, when response to diet and other non-pharmacological treatments (e.g. exercise, weight reduction) is inadequate.
Treatment of homozygous familial hypercholesterolaemia as an adjunct to diet and other lipid-lowering treatments (e.g. LDL apheresis) or if such treatments are not appropriate. Cardiovascular prevention, reduction of cardiovascular mortality and morbidity in patients with manifest atherosclerotic cardiovascular disease or diabetes mellitus, with either normal or increased cholesterol levels, as an adjunct to correction of other risk factors and other cardioprotective therapy
Adult Dosage
The dosage range is 5
80 mg/day given orally as a single dose in the evening. Adjustments of dosage, if required, should be made at intervals of not less than 4 weeks, to a maximum of 80 mg/day given as a single dose in the evening. The 80-mg dose is only recommended in patients with severe hypercholesterolaemia and high risk for cardiovascular complications.
Hypercholesterolaemia
