Drug Class Description
K+-sparing diuretics (potassium- sparing diuretics) / thiazide diuretics (thiazides).

Generic Name
Triamterene, hydrochlorothiazide [co-triamterzide]

Drug Description
Peach scored tablets coded SKF E93.

Presentation
Tablets, triamterene 50mg, hydrochlorothiazide 25mg (co- triamterzide).

Indications
Mild to moderate hypertension. Oedema.

Adult Dosage
Hypertension, initially 1 daily. Oedema, initially 1 twice daily after meals, reducing to usually 1 daily or 2 on alternate days. Maximum 4 daily.

Child Dosage
Not recommended.

Contra Indications
Hyperkalaemia. Severe or progressive renal failure, increasing hepatic dysfunction, hypercalcaemia, diabetic ketoacidosis, Addison's disease.

Special Precautions
Hepatic or renal impairment. Diabetes; acidosis. Gout. Pregnancy. Lactation. Pancreatitis.

Interactions
K+ supplements, K+-sparing diuretics, lithium, digitalis, antihypertensives, NSAIDs, ACE inhibitors, corticosteroids.

Adverse Reactions
Nausea, vomiting, diarrhoea, cramps, weakness, headache, dry mouth, rash, decrease in blood pressure, hyperglycaemia, hypercalcaemia. Rarely, blood dyscrasias, SLE, reversible renal failure.

Manufacturer
Goldshield

Drug Availability
(POM)

Updated
29 June 2009