Drug Class Description
Gonadotrophins.
Generic Name
Menotrophin
Drug Description
Active ingredientEach vial with dry substance contains highly purified menotrophin (human menopausal gonadotrophin, HMG) corresponding to 75 IU human follicle stimulating hormone (FSH) and 75 IU human luteinising hormone (LH).
Presentation
Powder for injection; and solvent for parenteral use.
Indications
Treatment of female and male infertility in the following groups of patients:
- Anovulatory women: MENOPUR can be used to stimulate follicle development in amenorrhoeic patients.
Clomiphene (or a similar ovulation inducing agent which influences steroid feed-back mechanisms) is the preferred treatment for women with a variety of menstrual cycle disturbances, including luteal phase insufficiency with anovulatory cycles and with normal prolactin, and also amenorrhoeic patients with evidence of endogenous oestrogen production but normal prolactin and normal gonadotrophin levels. Non-responders may then be selected for menotrophin therapy.
- Women undergoing superovulation within a medically assisted fertilisation programme: MENOPUR can be used to induce multiple follicular development in patients undergoing an assisted conception technique such as in-vitro fertilisation (IVF).
- Hypogonadotrophic hypogonadism in men: MENOPUR may be given in combination with human chorionic gonadotrophin (e.g. Choragon) for the stimulation of spermatogenesis. Patients with primary testicular failure are usually unresponsive.
Adult Dosage
Anovulatory infertility
