部份中文碘塞罗宁钠处方资料（仅供参考）
英文名：liothyronine sodium
商品名：CYTOMEL
中文名：碘塞罗宁钠片
生产商：辉瑞公司
药品介绍
CYTOMEL（碘塞罗宁钠）片，用于口服
最初的美国批准：1956年
警告：不得用于治疗肥胖或减轻重量，请参阅完整的BOXED警告的完整预定信息。
甲状腺激素，包括CYTOMEL，不应用于治疗肥胖症或减肥。
超出每日激素需求范围的剂量可能产生严重甚至危及生命的毒性表现。
最近的重大变化
适应症和用法：12/2018
剂量和用法：12/2018
禁忌症：12/2018
警告和注意事项：12/2018
作用机制
甲状腺激素通过控制DNA转录和蛋白质合成发挥其生理作用。 三碘甲腺原氨酸（T3）和L-甲状腺素（T4）扩散到细胞核中并与附着于DNA的甲状腺受体蛋白结合。 这种激素核受体复合物激活信使RNA和细胞质蛋白的基因转录和合成。
甲状腺激素的生理作用主要由T3产生，其中大部分（约80％）通过外周组织中的脱碘作用来自T4。
适应症和用法
CYTOMEL是一种L-三碘甲腺原氨酸（T3），适用于：
甲状腺功能减退症：原发性（甲状腺），继发性（垂体）和三级（下丘脑）先天性或后天性甲状腺功能减退症的替代
垂体甲状腺刺激素（TSH）抑制：作为手术和放射性碘治疗的辅助手段，用于治疗分化良好的甲状腺癌。
甲状腺抑制试验：作为抑制试验的诊断剂，以区分疑似轻度甲状腺功能亢进或甲状腺自主。
使用限制：
-在碘充足的患者中，不适用于抑制良性甲状腺结节和无毒性弥漫性甲状腺肿。
-未指出在亚急性甲状腺炎恢复期治疗甲状腺功能减退症。
剂量和给药
根据患者反应和实验室检查结果，每日口服一次CYTOMEL和个人剂量。
有关甲状腺功能低下症TSH在高分化甲状腺癌中的抑制和甲状腺抑制试验的推荐剂量，请参阅完整的处方信息。
当将患者转为CYTOMEL时，停止左旋甲状腺素治疗并以低剂量启动CYTOMEL。根据患者的反应逐渐增加剂量。
通过定期监测TSH和T3水平以及临床状态来确定治疗的充分性。
剂量形式和强度
片剂：5微克，25微克，50微克。
禁忌症
未矫正的肾上腺皮质功能不全
警告和注意事项
老年人和潜在心血管疾病患者的心脏不良反应：由于心脏不良反应（包括心房颤动）的风险增加，因此开始CYTOMEL低于完全替代剂量。
粘液性水肿昏迷：不要使用口服甲状腺激素药物来治疗粘液性水肿昏迷。
伴随肾上腺皮质功能不全的患者的急性肾上腺危象：在开始CYTOMEL治疗之前用替代糖皮质激素治疗。
预防甲状腺功能亢进或甲状腺功能减退症的不完全治疗：适当的剂量滴定和仔细监测对于预防甲状腺功能减退症的持续存在或甲状腺功能亢进的发展至关重要。
糖尿病控制恶化：糖尿病患者的治疗可能会加剧血糖控制并导致抗糖尿病药物或胰岛素需求增加。在开始，改变或停止甲状腺激素治疗后，仔细监测血糖控制。
与甲状腺激素过度替代相关的骨矿物质密度降低：过度替代可增加骨吸收并降低骨矿物质密度。给予最低有效剂量。
不良反应
CYTOMEL最常见的不良反应主要是治疗过量引起的甲状腺功能亢进：心律失常，心肌梗塞，呼吸困难，头痛，神经过敏，烦躁，失眠，震颤，肌肉无力，食欲增加，体重减轻，腹泻，热不耐受，月经不调，和皮疹。
要报告可疑的不良反应，请致电1-800-438-1985联系辉瑞公司，或致电1-800-FDA-1088或www.fda.gov/medwatch联系FDA。
药物相互作用
查看影响甲状腺激素药代动力学和代谢（例如吸收，合成，分泌，分解代谢，蛋白质结合和靶组织反应）的药物的完整处方信息，并可改变对CYTOMEL的治疗反应。
用于特定人群
怀孕可能需要使用更高剂量的甲状腺激素。
提供/存储和处理
CYTOMEL片剂（圆形，白色至灰白色）提供如下：
5mcg     100瓶     NDC：60793-115-01
25mcg    100瓶     NDC：60793-116-01
50mcg    100瓶     NDC：60793-117-01
储存在15°C至30°C（59°F至86°F）之间。
完整说明资料附件：
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=51452b31-ff68-4e0c-b982-c15502ebf1d3 
Cytomel–liothyronine Sodium
Liothyronine Sodium (AKA Cytomel, T3, Tertroxin, Tiromel, Thyroid hormone)
Chemical Name: sodium (S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
Molecular Weight: 672.96 g/mol
Formula: C15H11I3NNaO4
Original Manufacturer: ICI
Detection Time: Cannot be detected via urinalysis
Anabolic Rating: N/A
Androgenic Rating: N/A
Cytomel(T3)Overview and History of Cytomel (T3)
Cytomel is a brand and trade name for T3, which is Liothyronine Sodium. Liothyronine Sodium is a synthetic variant of the human body’s own thyroid hormone. It should be understood that the human body’s own natural endogenously manufactured thyroid hormone is actually known as Triiodothyronine, which is different from Liothyronine Sodium. Liothyronine is the L-isomer of Triiodothyronine. Liothyronine and Triiodothyronine are both nearly identical with one another, but Liothyronine is a more potent variant and is also better absorbed orally, which is why it has been developed into a prescription medicine and preparation known as Cytomel, Tiromel, Tertroxin, etc. Within a medical and clinical setting, Cytomel (T3) is utilized in the treatment of hypothyroidism, which is a condition whereby an individual’s thyroid gland is not secreting the proper and normal levels of thyroid hormone for proper function. In such a case, hypothyroidism is commonly diagnosed via a blood test that analyzes the serum hormone profile of thyroid hormones (T3, T4, and TSH, which is Thyroid Stimulating Hormone). Hypothyroidism also carries with it various symptoms such as a lack of energy, lethargy, weight and fat gain, hair loss, and alterations in skin colour and texture. T3 is the primary thyroid hormone used by the body.
Unfortunately, T3 is one of those compounds among the bodybuilding and athletic community that has gathered a large amount of mysticism, rumor, and lies that have been spread for years in regards to what it does, its use, and how it should be used. As a result, many within the anabolic steroid using community have become deathly afraid of T3, and shudder at the mere mention of its use. This profile will set these misconceptions straight and clarify many of the common misconceptions in regards to Cytomel.
T3 was originally formulated as a medicine by way of an extract from the thyroid gland. Many hormonal medicines originated in the same way, as being derived from the endocrine glands from the cadavers of animals and humans. The very first application of this thyroid extract was administered in 1981 to an individual who suffered from myxedema, which is a skin disorder that is normally the result of hypothyroidism[1]. Thyroid hormones were some of the very first hormonal medicines used in the field of endocrinology and in the treatment of many disorders and diseases. The very first thyroid extracts not only contained T3, but also T4, and these extracts were utilized for over 60 years in medicine. In the 1950s, methods of creating thyroid hormones synthetically took over and the previously used thyroid extracts were done away with. Liothyronine Sodium (T3) and Levothyroxine Sodium (T4) are the two most popular currently used synthetic thyroid hormones, and are widely available both in the United States as well as internationally. Cytomel tends to be the most widely utilized and most recognized brand name of T3, especially in the United States. In The USA, Cytomel is manufactured by King Pharmaceuticals.
T3, much like many other ancillary bodybuilding drugs is widely available with very little or no laws in regards to its sale, distribution, purchase, or use in most countries throughout the world. It is manufactured by dozens of different pharmaceutical companies across the world with different brand and trade names, as well as a diverse selection of generic T3 products. Because of the vast availability and manufacture of this product, it is not uncommon to find a wide variation in different T3 dosages in the different products. For example, T3 can commonly be seen in concentrations ranging from 5mcg, 25mcg, and all the way up to 50mcg tablets.
Chemical Characteristics of Cytomel (T3)
T3 (Liothyronine Sodium) is a synthetic variant of the body’s thyroid hormone Triiodothyronine.
Properties of Cytomel (T3)
T3 in the body is responsible for regulating the uptake of various nutrients into cells and into the mitochondria of those cells in order to effectively become utilized for the production and consumption of energy.  The mitochondria of every single cell in the body utilizes carbohydrates (primarily), fat, and even protein for the production of an energy source known as ATP (Adenosine Triphosphate). Through the intake of more T3, this production of ATP will increase, leading to an increased rate of energy consumption in the form of fats, carbohydrates, and protein. Hence, this is why the consumption of too much T3  without the use of anabolic steroids can result in muscle loss.
The bodybuilding and athletic world is attracted to the use of T3 as a physique and/or performance enhancing drug because of its capability to distinctly boost the body’s metabolism in the effort to metabolize body fat at a greater rate. T3 is traditionally utilize during cutting, dieting, and/or pre-contest phases of training due to the universal goal of these phases to break down body fat, though in recent years Cytomel has gained some popularity as a useful agent during bulking and mass gaining phases of training (normally in conjunction with anabolic steroids) in order to better efficiently process nutrients and/or to keep body fat levels down during periods of higher caloric intake. Cytomel (T3) is commonly used with anabolic steroids due to its significant impact on the body’s metabolism as a whole. It is very important to understand that T3 is indiscriminate in its metabolism boosting properties – it will increase the metabolism of fats, carbohydrates, and protein all equally. Therefore, beyond a particular dose of T3, there is an increased risk of muscle loss through increased turnover of protein. Through the use of anabolic steroids and a properly adjusted diet, this muscle loss as a result of T3 can be prevented as a result of the nitrogen-retaining and protein sparing properties of theanabolic steroids.
Cytomel (T3) is also commonly combined with other fat loss agents in order to increase its overall effect, as it does work synergistically with other fat loss agents. Some of these include Ephedrine, Clenbuterol, Albuterol, Human Growth Hormone (HGH) as well as other fat burning agents. The combination of T3 with anabolic steroids and other fat burning agents, as well as the possible interactions between them, will be further covered in greater detail in the Cytomel (T3) Doses and Cytomel (T3) Cycles sections of this profile.