| 简介：
部份中文氢化可的松琥珀酸钠处方资料（仅供参考）
英文名：Hydrocortisone Sodium Succinate
商品名：Solu-Cortef
中文名：氢化可的松琥珀酸钠冻干粉注射剂
生产商：辉瑞公司
ソル・コーテフ静注用250mg／ ソル・コーテフ静注用500mg／ ソル・コーテフ静注用1000mg
药物类别名称
肾上腺皮质激素
批准日期：2008年6月
商標名
Solu-Cortef for Intravenous Use 250mg
Solu-Cortef for Intravenous Use 500mg
Solu-Cortef for Intravenous Use 1000mg
一般名
ヒドロコルチゾンコハク酸エステルナトリウム（Hydrocortisone Sodium Succinate）
化学名
Monosodium 11β,17,21-trihydroxypregn-4-ene-3,20-dione 21-succinate
分子式
C25H33NaO8
分子量
484.51
構造式
性状
在白色粉末或质量,不闻,它是吸湿的。
水,易溶于甲醇或乙醇(95),几乎不溶于二乙醚。
逐渐被光着色。
处理注意事项
把它从外箱里拿出来后,保存它以避免光线。
药用药理学
1. 肾上腺功能障碍的补偿作用
2. 抗休克作用
3. 抗炎作用
4. 抑制抗过敏作用和抗体产生
适应症
[静脉注射250毫克,500毫克,1000毫克]
急性循环衰竭(出血性休克、创伤性休克)和休克样情况的紧急情况
[静脉注射250毫克,500毫克]
支气管哮喘
用法与用量
[静脉注射250毫克,500毫克,1000毫克]
急性循环衰竭(出血性休克、创伤性休克)和休克样情况的紧急情况
通常,一旦250~1000mg作为氢皮质酮是缓慢静脉注射或静脉注射静脉注射。在症状没有改善的情况下,它被适当地另外施用。
[静脉注射250毫克,500毫克]
支气管哮喘
1) 通常,在成人中,第一剂100~500mg作为氢皮质酮逐渐静脉注射或静脉注射。如果症状没有改善,每4-6小时逐渐加入50~200mg。应该注意的是,年龄,适当增加或减少,根据症状。
2) 通常,在2岁或以上的儿童中,第一剂5~7mg /kg作为氢皮质酮逐渐静脉注射或静脉注射。 如果症状没有改善,每6小时缓慢添加5~7mg/kg。应该注意的是,年龄,适当增加或减少,根据症状。
3) 通常,在2岁以下的儿童中,第一剂5mg/kg作为氢皮质酮逐渐静脉注射或静脉注射。如果症状没有改善,它逐渐添加一次5mg/kg每6-8小时。应该注意的是,年龄,适当增加或减少,根据症状。
临床表现
包括双盲试验、在日本210家医疗机构进行的静脉注射、2603例静脉注射等临床试验的疗效测定结果、有效病例数2447例(94.0%)。
包装
静脉注射
250mg:1 小瓶
500毫克:1瓶,5瓶
1000毫克: 1瓶
生产和销售
辉瑞公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明资料附件：http://www.info.pmda.go.jp/go/pack/2452400D3052_2_08/
Solu-Cortef
Generic Name: hydrocortisone sodium succinate
Dosage Form: injection, powder, for
Solu-Cortef injection
Uses
This medication is used to treat various conditions such as severe allergic reactions, arthritis, blood diseases, breathing problems, certain cancers, eye diseases, intestinal disorders, and skin diseases. It decreases your body's natural defensive response and reduces symptoms such as swelling and allergic-type reactions. Hydrocortisone is a corticosteroid hormone (glucocorticoid). This injectable form of hydrocortisone is used when a similar drug cannot be taken by mouth or when a very fast treatment is needed, especially in patients with severe medical conditions. Talk to your doctor about the risks and benefits of hydrocortisone, especially if it is to be injected near your spine (epidural). Rare but serious side effects may occur with epidural use.
This drug may also be used with other medications as a replacement for certain hormones.
How to use Solu-Cortef injection
This medication is given by slow injection into a vein or directly into a muscle as directed by your doctor. Dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often than prescribed without consulting your doctor.
If you have been using this medication for a long time, do not suddenly stop using it without your doctor's approval. Your dose may need to be gradually decreased to reduce symptoms such as weakness, weight loss, nausea, or extreme tiredness.
If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
Tell your doctor if your condition persists or worsens.
What conditions does Solu-Cortef injection treat?Side Effects
Stomach upset, headache, dizziness, menstrual period changes, trouble sleeping, increased appetite, weight gain, or pain/redness/swelling at the injection site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: bone/joint pain, easy bruising/bleeding, black stools, vomit that looks like coffee grounds, severe stomach/abdominal pain, increased thirst/urination, fast/slow/pounding/irregular heartbeat, shortness of breath, swelling of the ankles/feet, tendon pain, persistent weight gain, puffy face, unusual hair growth, thinning skin, slow wound healing, signs of infection (e.g., persistent fever/cough/sore throat, painful urination, eye pain/discharge), muscle weakness/pain, mental/mood changes (e.g., mood swings, depression, agitation), vision changes, seizures, unusual skin growths.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. |
