部份中文肾上腺素处方资料（仅供参考）

英文名：Adrenaline

商标名：EPIPEN

中文名：肾上腺素注射液

日文名：エピペン注射液

生产商：Mylan EPD Limited Liability Company

药品简介

药物分类名称

过敏性辅助治疗

批准日期：2011年9月

商標名

EPIPEN

一般名：〔日局〕アドレナリン（Adrenaline）

〔日局別名〕エピネフリン

化学名：4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]benzene-1,2-diol

分子式；C9H13NO3 

分子量；183.20

構造式

性状

该产品为白色至灰白色结晶粉末。

该产品易溶于甲酸或乙酸（100），极难溶于水，难溶于甲醇或乙醇（99.5）。

该产品溶于稀盐酸中。

该产品通过空气或光逐渐变成棕色。

批准条件

1.仅为了完全了解该药物安全性和有效性的医生开出和使用该药物，并能就该药物的使用提供适当和充分的指导， 应采取适当措施，如实施措施。

2.为了促进这种药物的正确使用，采取必要措施回收未使用的该药物制剂。

药用药理学

该药物含有化学合成的肾上腺髓质激素（肾上腺素），并作用于交感神经的α，β受体。

（1）对心血管系统的作用

在心脏中，窦房结的刺激速度加快，心率增加，心肌收缩力增加，心输出量增加以表达心脏活动。

对于血管，它表达收缩作用和扩张作用，扩张心脏的冠状动脉，收缩皮肤毛细血管，增加外周阻力，并增加血压。

（2）对血管以外的平滑肌的作用

它表达对支气管肌肉的松弛作用，并扩张支气管以增加呼吸量。

（3）其他作用

在哮喘中，它还具有抑制肥大细胞释放抗原诱导的炎性物质，减少支气管分泌和减少粘膜充血的作用。

适应症

由蜂毒，食物和药物等引起的过敏反应的辅助治疗（仅限于有过敏史的人或有过敏反应发生风险的人）

用法与用量

通常，推荐剂量为肾上腺素0.01mg/kg，考虑到患者的体重，肌肉注射肾上腺素0.15 mg或0.3mg。

包装

注射液

0.15mg：1本

0.3mg：1本

制造供应商

Mylan EPD Limited Liability Company

完处方资料附件：http://www.info.pmda.go.jp/go/pack/2451402G2020_3_03/

0.3 mg and 0.15 mg of Mylan Pharmaceutical, Epipe (R) injection solution,

0.3 mg and 0.15 mg of Epipen (R) injection solution of Mylan Pharmaceutical Co., Ltd., a Japanese corporation of Mylan Inc. (Nasdaq: NYL), were announced today in the Official Gazette.

Epipen (R) Injection is an adrenaline self-injecting drug for those who have a history of anaphylaxis or life-threatening allergic reactions. According to the drug price listing, 0.3 mg of epipen (R) injection solution is 10, Epipen (R) injection solution 0.15mg, and so on.

Heil Bresch, president of Mylan Inc., commented as follows. "We are very pleased with the decision of the Ministry of Health, Labor and Welfare to include EpiPen (R) injection at a drug price.According to the price list, the burden on the patient is drastically reduced, which in turn has more severe allergies People acquire epipen (R) injection solution to prepare for onset of anaphylaxis In Japan, schoolchildren who have food allergies and anaphylaxis are on the rise steadily, and now, about the entire schoolchildren in Japan This is particularly welcome news, as 2.6% have food allergies. "

In people in Japan who develop severe allergic symptoms or have the risk of anaphylactic symptoms, Epipen (R) injection is a drug with the possibility of life saving and is the first line of defense. According to the 2011 Anaphylaxis guidelines of the World Allergy Organization (WAO), adrenaline is classified as the first-choice medication for anaphylaxis treatment. In addition, the WAO guidelines state that up to 23% of adults receiving adrenaline injections with anaphylactic treatment require more than two doses to be administered.

Akihiko Honda, President and Representative Director of MYRAN Pharmaceutical, said, "This announcement makes epipen (R) injection liquid more affordable for everyone who has a history of anaphylaxis or is at risk of developing an episode It will be an important milestone for Mylan's goal of encouraging people. "

Furthermore, Doctor Akiyama Kazuo, director of National Hospital Organization Sagamihara Hospital, president of the Japan Allergy Society, said, "The decision of the Ministry of Health, Labor and Welfare to introduce insurance indications into epipen (R) injections is based on the seriousness of anaphylaxis and early The importance of prevention of treatment and severity will be recognized by the Ministry of Health, Labor and Welfare This decision will be effective not only for patients living with serious allergies but also for medical professionals It is an important thing. "

About anaphylaxis and food allergies

Anaphylaxis is a serious allergic reaction that occurs within a short period of time and can result in death due to swelling of the airways or a sharp decline in blood pressure. Anaphylaxis is caused by certain foods, insect bites, medicines, latex and other allergens.

Food allergy is a disease that occurs when the immune system misidentifies food proteins as threats and attempts to protect the human body from proteins by releasing chemical substances into the blood. Symptoms of anaphylaxis are caused by release of chemical substances. According to Japan's Food Allergy Handbook 2008, foods that often cause anaphylaxis in Japan include eggs, dairy products, wheat, crustaceans, fruits, buckwheat, fish, peanuts and so on.

About epipen (R) injection solution

Epipen (R) injection 0.3 mg and 0.15 mg are used as adjunctive therapy for anaphylactic reactions caused by bee venom, food, drugs etc. Subjects are limited to those with a history of anaphylaxis or those at high risk of developing anaphylaxis. Immediately after using epipen (R) injection solution, you need to go to a medical institution and receive medical treatment by a doctor. For more information please refer to Epipe (R) Injection Solution website.