部份中文马沙骨化醇处方资料（仅供参考）
商品名：OXAROL
英文名：Maxacalcitol
中文名：马沙骨化醇
生产商：中外药品
药品介绍
马沙骨化醇是日本中外制药公司开发的新型第三代活性维生素D类药物。其注射液于2000年上市，商品名为Oxarol，用于治疗肾透析（肾衰）患者的继发性甲状旁腺功能亢进症(SHPT)。马沙骨化醇软膏于2000年上市，商品名为Oxarol软膏，用于治疗银屑病等干癣类皮肤病。本品剂量很小，2.5~5.0微克/支，3次/周，肾透析（肾衰）患者一年用量不到1毫克。
オキサロール注2.5μg／オキサロール注5μg／オキサロール注10μg
藥用類別名稱
繼發性甲狀旁腺甲狀腺功能亢進治療劑
批准日期：2000年8月
商標名
OXAROL
一般名
マキサカルシトール（Maxacalcitol）（JAN）
慣用名
22‐oxacalcitriol １α, 25‐dihydroxy‐22‐oxavitamin D3
化学名
(＋)‐(5Z, 7E)‐(1S, 3R, 20S)‐20‐(3‐Hydroxy‐3‐methylbutyloxy)‐9, 10‐secopregna‐5, 7, 10(19)‐triene‐1, 3‐diol
構造式
分子式
C26H42O4
分子量
418.62
性　状
它是一種白色結晶性粉末。
很容易溶于甲醇, 易溶于乙醇 (99.5), 微溶于乙醚, 不易溶于水。
藥用藥理學
1. 對 pth 分泌的影響
在正常的牛甲狀旁腺細胞和慢性腎功能衰竭 (體外) 下, 對副甲狀旁腺甲狀腺功能亢進症患者甲狀旁腺細胞的 pth 分泌有抑制, 其效果與鈣調尿素三醇相當。
腎功能衰竭模型動物 (~ 6只腎拔毛科, 馬沙司他利托) 在不增加血清鈣值的劑量下顯示出 pth 分泌抑制作用。
2. 對骨骼的影響
研究了馬紮沙利托爾降低高代謝旋轉骨對志巴塔腎炎大鼠繼發性甲狀旁腺功能亢進的影響。 另外, 對於在犬腎功能衰竭模型中觀察到的骨病變, 也抑制了纖維化骨的形成。
3. 關於行動機制的研究
在正常大鼠和腎功能衰竭大鼠中, 馬佐沙利醇抑制甲狀旁腺前原蛋白 mrna 的表達。 此外, 馬科沙利醇通過作用於成骨細胞樣細胞 (體外) 促進骨鈣素基因的表達。
适应症
維持性透析中的繼發性甲狀旁腺甲狀腺功能亢進
用法与用量
通常情況下, 成人, 作為一個makoxalitol 就在透析結束前, 每週三次每次2.5 ~ 10μg, 注射到透析回路靜脈側 (靜脈注射)。 在不能獲得改善血清甲狀旁腺激素 (pth) 效果的情況下, 在注意高鈣血症表達的同時, 謹慎地逐步提高上限為一次20[mu]g。
包装
靜脈注射透析
Oxarol注为
2.5μg：1毫升×10安瓿
5μg：1毫升×10安瓿
10μg：1毫升×10安瓿
儲存方法、使用期限等。
避免凍結儲存方法, 並將光遮罩存儲在10°c 或以下。
在包裝中顯示的到期日期中使用
制造厂商
中外制药有限公司
注：以上中文不够完整，使用者以原处方资料为准。
完整说明附件：http://www.info.pmda.go.jp/go/pack/3112401A1026_1_09/ 
OXAROL Injection（Maxacalcitol）
OXAROL Injection 2.5 mcg（オキサロール注2.5μg） 
Brand name : OXAROL Injection 2.5 mcg
　Active ingredient: Maxacalcitol
　Dosage form: injection
　Print on wrapping:
Effects of this medicine
This medicine suppresses synthesis and secretion of parathyroid hormone, and decreases a concentration of parathyroid hormone in blood.
It is usually used to treat secondary hyperparathyroidism of the patient on dialysis.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have hypercalcemia (high value of calcium in blood).
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, inject at a venous side of dialysis circuit just before the completion of dialysis three times a week.
•The treatment period with this medicine depends on your response to the treatment.
Precautions while taking this medicine
•When the OTC drugs and foods containing calcium or vitamin D are taken too much, adverse drug reactions may possibly occur. Consult with your doctor when such drugs and foods are taken.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include pruritus and irritability. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•itching of the body, irritability  [hypercalcemia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Chugai Pharmaceutical Co., Ltd.Injection
Revised: 8/2012
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.