部份中文盐酸依普拉酮处方资料（仅供参考）
英文名：Eprazinone hydrochloride
商品名：Rezplen Tablet
中文名：盐酸依普拉酮片
生产商：太阳制药
药品简介
Rezplen（Eprazinone hydrochloride）具有祛痰作用，能使痰中酸性糖蛋白的多糖纤维性状改变，粘多糖纤维膨胀断裂，具有较强的粘液溶解作用。
レスプレン錠5mg/レスプレン錠20mg/レスプレン錠30mg
药效分类名称
镇咳/气道粘液溶解剂
批准日期：2002年7月
商標名
RESPLEN
一般名
エプラジノン塩酸塩（Eprazinone Hydrochloride）(JAN）
化学名
1‐(2‐Phenyl‐2‐ethoxy)ethyl‐4‐(2‐benzoyl)propylpiperazine dihydrochloride
構造式
分子式
C24H32N2O2・2HCl
分子量
453.45
性　状
白色结晶性粉末，无臭，味苦且舌头有轻微麻木。
它微溶于沸水，微溶于水或乙酸（100），微溶于甲醇，乙酸酐或乙醇（95），几乎不溶于乙醚。
融合点
约197°C（分解）
药效药理
1.祛痰药
（1）酸性粘多糖纤维/富DNA的纤溶作用
从慢性呼吸道疾病患者的痰液中加入盐酸依普拉酮，通过细胞学检查，改变了酸性粘多糖纤维和富含DNA的纤维的性质，并由于肿胀和横断的作用而变成了强粘液。它显示了裂解作用（体外）。
（2）降低痰液黏度的作用
体外向从慢性呼吸道疾病患者收集的痰液中添加盐酸盐酸环磷酮，经旋转粘度计法，奥斯特瓦尔德粘度计法，Hirsch改良法和斜率法检查，结果明确显示出降低粘度的作用。
（3）气道内分泌液的增加作用
通过使用小鼠检查盐酸依普拉地酮对气道分泌物的作用的结果，在给药后直至3小时观察到明显的增加气道分泌物的作用，并且即使当在气道中造成损害时，分泌物也会增加。
2.镇咳作用
在使用豚鼠，猫，狗等进行的电刺激，机械刺激和化学刺激实验中，其镇咳效果与可待因磷酸水合物相当。
适应症
在以下呼吸系统疾病中使用镇咳药和祛痰药
肺结核，肺炎，支气管扩张，支气管哮喘，突发/慢性支气管炎，上呼吸道炎症，普通感冒
用法与用量
盐酸依普拉地酮的成人每日剂量通常为60到90毫克，分3剂口服。
对于30毫克片剂
成人通常的剂量是每天口服3次，每次1片（盐酸依帕地龙30毫克）。
剂量可以根据您的年龄和症状进行调整。
在婴儿和儿童中，每天口服3次以下剂量的依帕地龙盐酸盐。
3岁且6岁以下
20-30毫克
6岁及10岁以下
30-45毫克
临床结果
感冒综合征，急性支气管炎和肺炎等急性呼吸系统疾病的有效率为79.4％（85/107例）。 慢性呼吸道疾病，如慢性支气管炎，支气管扩张和肺结核的有效率为50.6％（41/81例）。
包装
５mg錠：500錠(PTP）
20mg錠：500錠(PTP）
20mg錠：1000錠(PTP、バラ）
30mg錠：500錠(PTP）
30mg錠：1000錠(PTP）
制造商和分销商
太阳制药有限公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明资料附件：
https://www.info.pmda.go.jp/go/pack/2249001F1030_3_01/
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RESPLEN Tablet 20mg（レスプレン錠20mg）
Brand name : RESPLEN Tablet 20mg
　Active ingredient: Eprazinone hydrochloride
　Dosage form: white tablet (φ: 8.1mm, thickness: 4.3mm)
　Print on wrapping: レスプレン20
Effects of this medicine
This medicine works on central nerve and suppresses the excitation of cough center to stop coughing. Also, it increases bronchial secretion to decrease the viscosity of phlegm, consequently, to make it easy for a patient to cough out phlegm. It is usually used to treat symptoms of cough and phlegm caused by respiratory diseases such as cold, upper respiratory infection, bronchitis, and pneumonia.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reaction (itch, rash etc.) to any medicine.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, take 4-6 tablets (20-30mg of the active ingredient) at a time, 3 times a day. It should be adjusted according to your disease, age and symptoms. Toddlers/children should take the following amount of this medicine in 3 divided doses a day; for children aged 3 or over but under 6: 4-6 tablets (20-30mg of the active ingredient), for children aged 6 or over but under 10: 6-9 tablets (30-45mg of the active ingredient).
Strictly follow the instructions.
•This medicine is specially designed to avoid bitterness. Take it without chewing, otherwise you will note bitterness.
•If you missed a dose, take the missed dose as soon as possible and continue your regular dosing schedule. However, you should never take two doses at one time.
•If you accidentally took more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most commonly reported adverse reactions include loss of appetite, nausea/vomiting, stomach discomfort, diarrhea (including loose stool) and symptom of irritation. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store in a covered container, at room temperature (1-30℃). Keep away from direct sunlight and moisture.
•Discard the remainder. Do not store them. Ask the pharmacist how to discard.
Chugai Pharmaceutical Co., Ltd.Internal
Revised: 5/2007
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and