部分中文唑尼沙胺资料（仅供参考）
通用名:唑尼沙胺
通用名:（欧洲名）唑尼沙胺
化学名称:1,2-苯并异恶唑-3-甲磺
分子式:C8H8N2O3S
分子量:212.23
熔点:164〜168℃
構造式

性状
白细的黄色的结晶或结晶性粉末。它是易溶于丙酮或四氢呋喃，稍少溶于甲醇，微溶于乙醇（95），极微溶于水。
分配系数
1.04（氯仿/水溶剂，pH7.04，室温）
【作用与用途】
帕金森氏病（如果正在使用其它抗帕金森氏含左旋多巴疾病的药物制剂，甚至当获得不充分的效果）
【剂量与用法】
此剂，组合使用含左旋多巴制剂。
成人，一次25MG1日被口服给药。但应当指出的是，日变化（戴 - 关现象）在帕金森氏病，症状的改善一次50MG1日口服给药。
包装
トレリーフOD錠25mg
［PTP］30錠（10錠×3）、100錠（10錠×10）
制造厂商
大日本住友制药有限公司
Brand name : TRERIEF OD Tablets 25mg
　Active ingredient: Zonisamide
　Dosage form: white tablet, diameter 8mm, thickness 3.2mm
　Print on wrapping: トレリーフOD, 25mg, DS023
Effects of this medicine
This medicine enhances/prolongs antiparkinsonian effect of levodopa by elevating dopamine level, and improves motor symptoms and circadian change of symptoms (wearing-off phenomenon) in Parkinson's disease.
It is usually used concomitantly with levodopa-containing products to treat Parkinson's disease.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
•If you are pregnant, possible pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, take 1 tablet (25 mg of the active ingredient) once a day, concomitantly with levodopa-containing products. For improvement of circadian change of symptoms in Parkinson's disease, take 2 tablets (50 mg) once a day, concomitantly with levodopa-containing products. Strictly follow the instructions.
•The medicine is designed to be taken without a glass of water. Take it with saliva after soaking it with saliva on the tongue and crunching it lightly with the tongue. Alternatively, it can be taken with a glass of water/lukewarm water like other general medicines.
•If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•This medicine may cause drowsiness, lack of attention/concentration/reflex action ability. Avoid driving a car or operating dangerous machinery after taking this medicine.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include drowsiness, loss of appetite, dyskinesia, nausea, hallucination, loss of vitality, dizziness, lightheadedness, rash and itch. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•sudden fever, muscle stiffness, shaking in limbs  [malignant syndrome]
•fever, widespread erythema/bulla, skin exfoliation  [toxic epidermal necrolysis, mucocutaneous ocular syndrome, exfoliative dermatitis]
•anemic symptoms, sore throat, general malaise, bleeding tendency  [aplastic anemia, agranulocytosis, pure red cell aplasia, thrombopenia]
•muscle pain in limbs, stiffness, numbness  [rhabdomyolysis]
•lower back pain, abdominal pain, bloody urine  [calculus in kidney/urinary tract]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them. Ask the pharmacist or healthcare facility how to discard them.
Sumitomo Dainippon Pharma Co.,Ltd.Internal
Published: 1/2015