部份中文盐酸司维拉姆处方资料（仅供参考）
英文名：Sevelamer Hydrochloride
商标名：Phosblock Tablets
中文名：盐酸司维拉姆片
生产商：协和发酵麒麟
药品简介
新药Phosblock(Sevelamer Hydrochloride)为螯合剂解毒剂和拮抗剂，用于治疗成年终末期肾病（ESRD）患者的高磷血症，进行血液透析或腹膜透析。
Phosblock推荐的起始剂量为每次0.8g或1.6g，每日三次，可随餐服药。剂量调整必须监测患者血清磷水平，剂量调整的间隔为2~4周，
フォスブロック錠250mg
药用分类名称
高磷血症治疗剂（磷结合聚合物）
批准日期：2003年4月
商標名
PHOSBLOCK TABLETS 250mg
一般名
セベラマー塩酸塩(Sevelamer Hydrochloride)(JAN)
本質
〔英名〕Hydrochloride of prop-2-en-1-amine polymer with 1-chloro-2,3-epoxypropane
〔日本名〕プロプ-2-エン-1-アミンと1-クロロ-2,3-エポキシプロパンの重合物の塩酸塩
構造式
性状
它是白色到淡黄色的白色粉末。
乙酰乙酰、2-丙醇、0.1mol/L盐酸溶液，几乎不溶于0.1mol/L氢氧化钠溶液和水。
非常吸湿。
药效药理
1. 效果和效果
（1） 血清磷浓度和血清钙和磷含量的改善效果
正常大鼠，在仓鼠中，血清磷浓度的降低通过混合施用塞贝拉默盐酸盐观察到。 此外，部分肾切除大鼠，在腺苷诱导和腺苷诱导肾衰竭大鼠中，血清磷浓度和血清钙磷含量的上升被抑制。 此外，在单肾切除Thy1肾衰竭大鼠中，观察到血清磷浓度和血清钙磷含量的降低，显示高。
（2） 异地钙化进展抑制作用
在腺苷诱导的肾衰竭大鼠中，胸主动脉的钙化在病理对照组10例中，高度为7例，中度为1例，小例为1例，2%的塞贝拉马盐酸盐的诱饵混合施用，虽然10例中观察到高度钙化，但在9例中未观察到病变，该剂的异位置钙化进展抑制效果已显示。
（3） 改善血清PTH浓度的效果
在部分肾切除大鼠中，血清PTH浓度显示高（平均789.4pg/mL），通过混合施用1和3%的盐酸塞贝拉默，分别下降到平均192.1和68.7pg/mL和假手术组值（平均43.6pg/mL）附近。 此外，类似的血清PTH升高抑制或减少作用，亚得里亚霉素诱导，在腺苷诱导和单肾切除Thy1肾衰竭大鼠中观察到。
（4） 肾骨异营养症进展抑制作用
在腺苷诱导的肾衰竭大鼠中，骨量、纤维量和孔隙度显示高，但表现出高代谢旋转骨损伤，由于血清PTH的上升，1和2%的塞贝拉默盐酸盐的诱饵混合施用，所有这些参数被显著抑制。
2. 作用机制
盐酸塞贝拉默是一种多阳离子聚合物，通过促进粪便中的磷排泄与胃肠道中的磷结合，降低血磷浓度，抑制胃肠道的磷吸收。
适应症
改善以下患者的高磷血症
透析期间慢性肾衰竭患者
用法与用量
通常，在成人中，一次1至2克作为盐酸塞贝拉马在每天3次饭前口服。
另外，年龄，症状，但适当增加或减少血清磷浓度的程度，最高剂量为每天9g。
包装
片剂
250mg： 100 片（PTP），1000片（PTP）
制造分销商
协和麒麟有限公司
注：以上中文资料不够完整，使用者以原处方资料为准。
完整资料附件：
https://www.info.pmda.go.jp/go/pack/2190025F1028_3_07/
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PHOSBLOCK TABLETS 250mg（Sevelamer hydrochloride）
Brand name :PHOSBLOCK TABLETS 250mg
　Active ingredient:
Sevelamer hydrochloride
　Dosage form:
white to faintly yellowish white tablet, diameter: 9 mm, thickness: 6.2 mm
　Print on wrapping:
フォスブロック250, PHOSBLOCK250, KR01
Effects of this medicine
This medicine binds to phosphorus contained in food in the gastrointestinal tract to promote the fecal excretion of phosphorus. It consequently suppresses gastrointestinal absorption of phosphorus and decreases blood phosphorus concentration.
It is usually used to improve hyperphosphatemia occurred in chronic renal failure patient on dialysis.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions(itch, rash, etc.)to any medicines.
If you have intestinal obstruction.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products.(Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is((to be written by a healthcare professional))
In general, for adults, take 4 to 8 tablets (1 to 2 g of the active ingredient) at a time, 3 times a day just before meals. The dosage may be adjusted according to your age, symptoms and serum phosphorus concentration. However, the maximum daily dose is 36 tablets(9 g). Strictly follow the instructions.
Take it with water or lukewarm water, without keeping in the mouth for a long time or chewing. If it is difficult to take all the tablets at once, take in several batches.
If you miss a dose and realize it during or just after meals, take the missed dose as soon as possible. Otherwise, skip the missed dose and take the next dose before the next meal. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include constipation/aggravated constipation, abdominal pain, abdominal distension, nausea, indigestion, and diarrhea/loose stool. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
severe constipation, persistent abdominal pain, vomiting [intestinal tract perforation, intestinal obstruction]
tenderness in lower abdomen, fever, melena[diverticulitis, ischemic enteritis]
vomiting of blood, melena, nausea/vomiting[gastrointestinal bleeding, gastrointestinal ulcer]
general malaise, loss of appetite, yellowing of the skin and the white of eyes[hepatic function disorder]
constipation, worsening of constipation, abdominal pain, abdominal bloating [constipation, aggravated constipation, abdominal pain, abdominal distension]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
Discard the remainder. Do not store them.
Internal
Revised: 3/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.