部份中文盐酸坦索罗辛处方资料（仅供参考）
英文名：Tamsulosin Hydrochloride
商品名：Harnal D Tablets
中文名：盐酸坦索罗辛口崩片
生产商：安斯泰来制药
药品简介
Harnal D（Tamsulosin）是一种选择性α肾上腺素受体拮抗剂，可以改善尿道、膀胱颈部及前列腺平滑肌功能，从而改善排尿异常症状。 
ハルナールD錠0.1mg/ハルナールD錠0.2mg
药用类别名称
前列腺增生症排尿障碍的改良剂
批准日期：2005年6月
商標名
HarnalD Tablets 0.1mg
HarnalD Tablets 0.2mg
一般名
タムスロシン塩酸塩（Tamsulosin Hydrochloride)
化学名
5-｛(2R )-2-[2-(2-Ethoxyphenoxy)ethylamino]propyl｝-2-methoxybenzenesulfonamide monohydrochloride
構造式
分子式
C20H28N2O5S・HCl
分子量
444.97
融点
約230℃（分解）
性状
盐酸塔穆洛辛是一种白色晶体。 易溶于甲酸, 不易溶于水, 不易溶于醋酸 (100), 很难溶于乙醇 (99.5)。
操作注意事项
注意：
本产品是由内袋保持质量高的耐湿性。
药用药理学
1. 药理作用
(1) 人的作用
在人前列腺标本的受体结合实验中, 它显示了2.2倍, α-1受体阻断作用是盐酸普拉佐辛中的Fentramine甲酸盐的40倍。
(2) 动物行动
1) 交感神经α受体阻滞作用
在大鼠脊髓标本中受体结合实验和切除兔主动脉标本的提取实验中, α1受体选择性和竞争性切断, 其作用是盐酸苯甲唑嗪的1/2~ 22倍, 比芬替明甲磺酸盐强 45 ~ 140倍。此外, 切除兔主动脉, 在切除大鼠输浴室和切除豚鼠肠道的切除实验中, 该药物的选择性为 5400至24000倍, 相对于α2受体。
2) 对下尿路 (尿道、膀胱) 和前列腺的影响
在前列腺和膀胱基础平滑肌标本的切除实验中, 从盐酸纤溶辛中提取的α-1受体阻断作用比fentramine mesyl酸盐强87至320倍。
此外, 在麻醉犬中, 由α1受体刺激剂抑制尿道压力增加的强度是舒张压升高的13倍。
3) 改善排尿障碍的效果
在麻醉雄性狗中, 减少前列腺压力的尿道压力曲线。另一方面, 麻醉大鼠对有节奏的膀胱收缩和膀胱压力曲线没有影响。
2. 作用机制
通过阻断尿道和前列腺的α-1受体, 降低尿道压力曲线, 改善与前列腺肥大相关的排尿障碍。
适应症
前列腺增生症伴的排尿困难
用法与用量
通常情况下, 成人在食用0.2毫克盐酸他莫洛辛后, 每天口服一次。
应该注意的是, 年龄, 根据症状增加或减少。
临床结果
前列腺部分尿道压力明显降低, 尿流量和残余尿量改善。分析目标276个实例的总体改进结果如下。此外, 双盲比较试验的结果, 在一一剂Halnar0.2毫克胶囊中观察到的有用性, 每天一次。
包装
片
D片
0.1毫克:140片 (14片x10)


0.2毫克: 140片(14片x10)
0.2毫克: 300片(瓶装)
0.2毫克: 560片(14片x40)
制造商
安斯泰来制药公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明资料附件：
http://www.info.pmda.go.jp/go/pack/2590008F1026_1_11/
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Brand name:Harnal D Tablets 0.1mg
Active ingredient:Tamsulosin hydrochloride
Dosage form:white tablet (φ: 7.5mm, thickness: 3.3mm)
Print on wrapping:(Face): ハルナール D ,0.1mg ,口腔内崩壊錠, (Back): ハルナール
D ,0.1mg , house mark , house markHA0.1 , Astellas
Effects of this medicine
This medicine reduces urethral pressure by its blocking activity on alpha 1 receptors in the urethra and prostate,
thus improving impaired urination associated with prostatic hyperplasia.
It is usually used for the treatment of impaired urination associated with prostatic hyperplasia.
Before using this medicine, be sure to tell your doctor and pharmacist
・If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
・If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal
effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
・Your dosing schedule prescribed by your doctor is<< to be written by a healthcare professional>>
・In general, for adults, take 2 tablets (0.2mg of the active ingredient) at a time, once daily after a meal. The dose may
be adjusted according to your age and symptoms. Strictly follow the instructions.
・Take the tablet with water or lukewarm water in the same way as you usually take tablets. Since the tablet promptly
dissolves in saliva, you may place it on your tongue, soak it in saliva, push it with your tongue and swallow it
together with saliva.
・Do not crunch the tablet when you take it.
・Do not take the tablet without water when you are lying down.
・If you miss a dose, skip the missed dose and continue your regular dosing schedule from the following day. You
should never take two doses at one time.
・If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
・Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
・The medicine may cause dizziness. Pay close attention if you work at heights, drive a car or are involved in
dangerous activities.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include dizziness, stomach discomfort, itching, rash and urticaria. If
any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated
in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor
immediately.
・fainting, loss of consciousness [syncope, unconsciousness]
・general malaise, loss of appetite, yellowing of the skin and the whites of the eyes [hepatic function disorder,
jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your
doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
・Keep out of the reach of infants and children. Store away from direct sunlight, heat and humidity.
・Discard the remainder. Do not store them.
Internal
Revised: 11/2012
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval
details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is
important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response,
patients should understand their medication and cooperate with the treatment.