部份中文瑞巴派特处方资料（仅供参考）
商标名：Mucosta ophthalmic suspension
英文名：Rebamipide
中文名：瑞巴派特点眼液点眼液UD2％
生产商：大冢制药
药品介绍：
Mucosta是 大冢制成滴眼液UD2%主要作用是修复干眼引起眼角膜、结膜表皮的病灶，保护黏膜和促进黏膜组织再生修复，及增加粘蛋白泪液正常分泌功能来改善干眼症。
ムコスタ点眼液UD2％
藥用類別名稱
乾眼症治療劑(粘液素生產促進劑)
批准日期：2012年1月
商標名
Mucosta ophthalmic suspension UD2％
一般名
レバミピド〔Rebamipide（JAN）〕
化学名
（2RS）-2-（4-Chlorobenzoylamino）-3-（2-oxo-1,2-dihydroquinolin-4-yl）propanoic acid
構造式
分子式
C19H15ClN2O4
分子量
370.79
性状
它是一種白色的結晶性粉末, 嘗起來很苦。n, 易溶于n-二甲基甲醯胺, 很難溶于甲醇或乙醇(99.5), 不易溶于水。
n, n-二甲基甲醯胺溶液(1→20)不具有光轉特性。
熔點
約 291°c(拆卸)
操作注意事項
這種劑, 因為有一個情況下, 粒子是難以分散, 即使動搖的儲存方法, 向上存儲的眼科出口。
藥用藥理學
1. 藥理作用
(1) 促進結膜粘液素生產的效果
當正常或眼黏液模型的家兔再灌注時, 劑量依賴性和結膜組織粘液量增加。
(2) 促進角膜粘液產生的作用
1% 的左旋皮多眼科溶液重複滴眼滴到正常或眼黏液還原模型的家兔, 角膜組織粘液量增加。
(3) 改善角膜結膜上皮病的療效
1% 的左旋皮多眼科溶液反復將家兔注入眼部粘液減少模型, 改善角膜和結膜上皮紊亂。
2. 作用機制
左旋皮多增強角膜上皮細胞的粘液基因表達, 增加細胞和培養上清液中的粘液量。此外, 促進角膜上皮細胞的增殖, 增加結膜杯狀細胞的數量。
适应症
乾眼症
用法与用量
通常情況下, 一次一滴水, 每天滴四次。
包装
点眼液UD2％：
0.35mL×112本（28本×4）
生产厂家
大冢制药
注：以中文处方资料不够完整，使用者以原处方资料为准。
完整说明书附件：http://www.info.pmda.go.jp/go/pack/1319760Q1029_1_05/
Mucosta ophthalmic suspension UD2% : 56bottles
Description
This medicine enhances the production of mucin, a component of tears, to stabilize tear film and thereby improve corneal epithelium damage.
It is usually used to treat dry eye.
Presentation
Feature
white, aqueous, sterile ophthalmic suspension (filled in 0.35 mL plastic bottle), (bottle) colorless, (label) pink
Active Ingredients
Rebamipide
Effect/Efficacy
This medicine enhances the production of mucin, a component of tears, to stabilize tear film and thereby improve corneal epithelium damage.
It is usually used to treat dry eye.
Usage/Dosage
In general, instill 1 drop at a time, 4 times daily. Strictly follow the instructions.
Since the medicine is a suspension, hold the lower part of the container and flick toward the widened part to disperse the medicine before instilling.
Avoid touching the eye directly with the tip of the container when instilling the medicine.
After instillation, close the eyes and press the area of the lacrimal sac for 1 to 5 minutes before re-opening the eyes.
Wipe any excess medicine around the eyes with clean gauze or tissue.
This medicine is a single use disposal preparation. Dispose of any medicine remaining in the container after use.
If you need to instill another ophthalmic solution, wait at least 5 minutes between each instillation.
If you miss a dose, instill a dose as soon as possible. However, if it is almost time for the next scheduled dose, skip the missed dose and continue your regular dosing schedule. You should not use two doses at one time.
If you accidentally use more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop using this medicine unless your doctor instructs you to do so.
Cautions
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions (itch, rash, etc. ) to any medicines. If you use contact lenses.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines)
In general, Instill 1 drop at a time, 4 times daily.Strictly follow the instructions.
Since the medicine is a suspension, hold the lower part of the container and flick at the widened body to disperse the medicine before instilling.
Since the medicine is a suspension,shake container well to disperse the medicine before instilling.
Avoid touching the eye directly with the tip of the container when instilling the medicine.
After instillation,close the eyes and press the area of the lacrimal sac for 1 to 5 minutes before re-opening the eyes.
Wipe any excess medicine around the eyes with clean gauze or tissue.
Dispose of any medicine remaining in the container after it is used once.
If you need to instill another ophthalmic solution,wait at least 5 minutes between each instillation.
If you missed a dose, instill a dose as soon as possible.However,if it is almost time for the next scheduled dose, skip the missed dose and continue your regular dosing schedule.You should never take two doses at one time.
If you accidentally used more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop using this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
Since the medicine is white aqueous sterile ophthalmic suspension, avoid operating machines and vehicles because the vision may be temporarily blurred after instillation.
If you have an unusual ocular sensation, consult with your doctor, because the active ingredient of the medicine may be absorbed into soft contact lenses.
Contraindication
The most commonly reported adverse reactions include bittertaste, eye irritation, eye pruritus, blurred vision.If any of these symptoms occur, consult with your doctor or pharmacist.
https://www.otsuka-elibrary.jp/di/prod/product/news/PG2701.pdf
https://www.otsuka-elibrary.jp/di/prod/product/news/OB0201.pdf