部份中文地夸磷索四钠处方资料（仅供参考）
商品名：Diquas Sodium ophthalmic solution
英文名：Diquafosol
中文名：地夸磷索四钠滴眼液
生产商：参天制药
药品简介
Diquas（Diquafosol Sodium，ジクアス点眼液3％）是全球获准上市的首个P2Y2受体激动剂滴眼液，以新作用机制治疗干眼病：通过促进水和黏蛋白分泌改善干眼病症状，使泪膜更接近正常状态。在日本的临床研究中，未发现严重的眼部和全身性不良反映。Diquas用药的耐受性好，故可用于长期治疗干眼病症状。
药效分类名称
干眼症治疗
（粘蛋白/促水分泌眼药水）
批准上市日期：2011年11月
商標名
DIQUAS ophthalmic solution 3%
一般名
ジクアホソルナトリウム（Diquafosol Sodium）
化学名
Tetrasodium P 1, P 4-bis（5'-uridyl）tetraphosphate
構造式

分子式
C18H22N4Na4O23P4
分子量
878.23
性状
本品为白色结晶性粉末。极易溶于水，溶于甲酰胺，极难溶于甲醇，几乎不溶于乙醇。
药效药理
1.作用机制
地夸磷索钠作用于结膜上皮和杯状细胞膜上的 P2Y2 受体，增加细胞内钙浓度，从而促进水和粘蛋白的分泌。
2. 含有粘蛋白的促泪液分泌作用
(1) 在正常动物（家兔和大鼠）中，单次滴注地夸磷索钠促进结膜细胞分泌泪液和粘蛋白。
(2) 在大鼠干眼模型中，单次滴加地夸磷索钠促进泪液分泌。此外，结膜组织中的粘蛋白量因反复滴注而增加。
3. 角膜上皮细胞粘蛋白产生促进作用
地夸磷索钠促进角膜上皮细胞中粘蛋白基因的表达和蛋白质的产生。
4. 角膜上皮疾病的改善
通过重复滴注地夸磷索钠，每天6次，持续4周，大鼠干眼模型中的角膜上皮紊乱以浓度依赖性方式得到改善，最大效果显示在 1% 或更多。另外，1%重复滴注2周，一天6次以上的改善效果最大。
适应症
干眼症
剂量与用法
一次滴入1滴，每天6次。
包装规格
塑料吸管
５ｍＬ/支×10管/盒
５ｍＬ/支×50管/盒
制造商和分销商
参天药业股份有限公司
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明附件：
https://www.info.pmda.go.jp/go/pack/1319758Q1021_1_09/
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DIQUAS ophthalmic solution 3%(ジクアス点眼液3％)
Brand name : DIQUAS ophthalmic solution 3%
　Active ingredient: Diquafosol sodium
　Dosage form: colorless, limpid ophthalmic solution, 5mL, (bottle) colorless, limpid, (cap) clear bright blue
　Printings on wrapping:
Effects of this medicine
This medicine stimulates the secretion of mucin and water in the ingredients of tears.
It helps improve tear conditions, and cures corneal and conjunctival injuries.
It is usually used to cure dry eye.
Before using this medicine, tell your doctor/pharmacist
If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you wear contact lenses.
If you are pregnant or breastfeeding.
If you are using any other prescription or nonprescription (OTC) medicine. (It is important to reduce the risk of drug interactions.)
Dosage regimen (proper use of this medicine)
Your dosage regimen is:(order of your doctor)
General dosage regimen: Apply 1 drop at a time, 6 times a day. Strictly follow the instructions of your doctor/pharmacist.
Before using, wash your hands thoroughly with soap and running water. Pull down your lower eyelid so that the dropper tip does not touch eye or eyelashes. After dropping the solution into your eye, do not blink, and keep your eyes closed for a while. Wipe off any excess liquid with a clean gauze or tissue. If you need to use other eye drops at the same time, wait more than 5 minutes.
Missed dose: Apply as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular applying schedule.
DO NOT use double doses to make up for the missed dose.
Overdose: If you used too much of the medicine (more than ordered), check with your doctor/pharmacist.
Others: Do not stop using the medicine without the instructions of your doctor.
Precautions while using this medicine
Do not use the medicine while you wear liquid-containing contact lenses.
Side effects of this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: stinging eyes, eye mucus, bloodshot eyes, eye pain, itchy eyes, foreign body sensation in eyes, eye discomfort, etc.In rare cases, symptoms described below may be the sign of side effects indicated in brackets [ ]. If they occur, stop taking your medicine and check with your doctor immediately.No pertinent entries.Other side effects not listed here may occur. Check with your doctor/pharmacist if you have any worrisome symptom.
Storage and other information
Keep out the reach of children. Store away from heat and direct sunlight.
Discard the remainder. Do not store them.
Manufacturer's name : Santen Pharmaceutical Co.,Ltd. 621985701