部份中文盐酸奥洛他定处方资料（仅供参考）
商品名：Allelock
英文名：Olopatadine Hydrochloride
中文名：盐酸奥洛他定片
生产商：协和发酵麒麟
药品简介
由协和发酵麒麟开发的新代抗组胺首选药物Olopatadine (商标名：Allelock)在日本批准上市，用于过敏性鼻炎、荨麻疹、皮肤病剌激和多型渗出性红斑等在内的一些过敏反应。标准剂量为5毫克，每天2次。由于Olopatadine效果强，副作用注，在日本是第一个授予较高（II组）补贴额的抗过敏药。在日本，过敏性鼻炎影响着约1500万人次（其中500万看过医生）。
アレロック錠2.5／アレロック錠5
药效分类名称
过敏性疾病的补救措施
批准日期：2001年2月
欧文商標名
ALLELOCK Tablets
一般名
オロパタジン塩酸塩 Olopatadine Hydrochloride
化学名
{11-[(1Z)-3-(Dimethylamino)propylidene]-6,11-dihydrodibenzo [b, e] oxepin-2-yl}acetic acid monohydrochloride
分子式
C21H23NO3・HCl＝373.87
化学構造式
性状
白色结晶或结晶性粉末，无气味和苦味。
溶解度
它极易溶于甲酸，微溶于水，极微溶于乙醇（99.5）。
熔点
约250°C（分解）
分配系数
logP'OCT =0.3[测量方法：烧瓶振荡法正辛醇/pH7.4缓冲溶液]
药效药理
1.作用机理
盐酸奥洛他定具有选择性的组胺H1受体拮抗作用，还具有抑制化学介质（白三烯，血栓烷，PAF等）产生/释放的作用，还具有抑制神经递质速激肽释放的作用。
2.药理作用
（1）抗组胺作用
在受体结合实验中，对组胺H1受体有很强的拮抗作用（Ki值：16nmol/L），但对毒蕈碱型M1受体的亲和力很小，且具有选择性。另外，已经证实其对豚鼠中组胺诱导的气道收缩反应也具有抑制作用。
（2）实验性抗过敏作用
在实验性变应性鼻炎模型（豚鼠，大鼠）中，抑制了抗原诱导的血管通透性过高和鼻阻塞。
它强烈抑制了大鼠和豚鼠的被动皮肤过敏反应和过敏性气道收缩。
它抑制了活动性致敏豚鼠的延迟气道收缩和炎性细胞浸润。
在豚鼠中，它还抑制了血小板活化因子（PAF）诱导的气道高反应性。
（3）对化学介体的生产和释放过程的影响
抑制组胺从大鼠腹膜肥大细胞中释放（IC30值; 72μmol/L：卵清蛋白刺激，110μmol/L：二硝基苯基化牛血清白蛋白刺激，26μmol/L：A-23187刺激，270μmol/L：化合物48 （80/80）并作用于花生四烯酸代谢系统，人类嗜中性白细胞产生的白三烯（IC30值; 1.8μmol/L），血栓烷（IC30值; 0.77μmol/L），PAF（产量：10μmol/L抑制52.8％，释放：10μmol/L抑制26.7％等。已经证实脂质介体的产生或释放被抑制。
（4）速激肽释放抑制作用
已知从感觉神经末梢释放的神经递质速激肽与过敏性疾病的发作和恶化有关。
盐酸奥洛他定可抑制豚鼠主要支气管肌肉制剂在电场电刺激过程中的速激肽相关的收缩反应（IC30值；5.0μmol/L）。认为该作用归因于通过激活钾通道（SKCa通道：小电导Ca 2+-活化的K +通道）的速激肽释放抑制作用。
适应症
成人：过敏性鼻炎，荨麻疹，与皮肤疾病有关的瘙痒（湿疹/皮炎，瘙痒，寻常性瘙痒，寻常型牛皮癣，多形性红斑）
儿童：与过敏性鼻炎，荨麻疹和皮肤病（湿疹/皮炎，皮肤瘙痒症）相关的瘙痒症。
用法与用量
成人：过敏性鼻炎，荨麻疹，与皮肤疾病有关的瘙痒（湿疹/皮炎，瘙痒，寻常性瘙痒，寻常型牛皮癣，多形性红斑）
成人：通常的成人剂量是每天早晨和就寝时口服两次，每次口服5毫克盐酸奥洛他定。
剂量可以根据年龄和症状进行调整。
儿童：与过敏性鼻炎，荨麻疹和皮肤病（湿疹/皮炎，皮肤瘙痒症）相关的瘙痒症。
儿童：通常，对于7岁以上的儿童，每天早晨和就寝时间口服两次5毫克的奥洛他定盐酸盐。
包装
片剂
2.5：[PTP] 100片（10片x10）、500片（10片x50）
5：[PTP] 100片（10片x10）、500平板电脑（10平板电脑x50）、700片（14片x50）
、1000片（10片x100）、[玫瑰] 500片
制造商
协和发酵麒麟株式会社
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整说明资料附件：
https://www.info.pmda.go.jp/go/pack/4490025F1023_1_28/
ALLELOCK Tablets 2.5（Olopatadine hydrochloride）
Brand name:ALLELOCK Tablets 2.5
　Active ingredient:Olopatadine hydrochloride
　Dosage form:pale yellowish red tablet, diameter: 6.1 mm, thickness: 3.0mm
　Print on wrapping:KH 020 2.5mg アレロック
Effects of this medicine
This medicine suppresses production and release of allergic substances (histamine, etc.) in the body. It also resolves and relieves allergic symptoms in skin and nose by inhibiting activities of these allergic substances.
It is usually used in the treatment of allergic rhinitis, hives, and itch associated with skin diseases.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions(itch, rash, etc.) to any medicines.
If you have renal disorder or hepatic disorder.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products.(Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is((to be written by a healthcare professional))
In general, for adults, take 2 tablets (5 mg of the active ingredient)at a time, twice daily, in the morning and before bedtime. The dosage may be adjusted according to the disease, age or symptoms. For children 7 years old or over, take 2 tablets (5 mg) at a time, twice daily, in the morning and before bedtime. Strictly follow the instructions.
If you miss a morning dose and notice it until noon, take a dose as soon as possible. However, if you notice it late in the day, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
The medicine may cause sleepiness. Avoid driving a car or operating dangerous machinery.
If you take the medicine for treatment of pollinosis, you need to take the medicine until the pollen season ends.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include sleepiness, malaise, dry mouth, nausea and hypersensitivity (rash, edema, itch, breathing difficulty). If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
general malaise, loss of appetite, nausea, yellowing in skin and white of eyes  [fulminant hepatitis, hepatic dysfunction, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
Discard the remainder. Do not store them.
Internal
Revised: 4/2017
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.