部份中文果糖处方资料（仅供参考）
果糖注射液
通用名：果糖注射液
成分
果糖　　
适应症
用于糖尿病、肝病病人供给能量和补充体液。可用于急性乙醇中毒的辅助治疗。
用法用量
本品用以静注或静滴，用量视病情而定。常用量为每次500~1000ml　　
不良反应
1.循环和呼吸系统：过量输入可引起水肿，包括周围水肿和肺水肿。
2.内分泌和代谢：滴速过快(≥1g/kg/hr)可引起乳酸性酸中毒、高尿酸血症以及脂代谢异常。
3.电解质紊乱：稀释性低钾血症。
4.胃肠道反应：偶有上腹部不适、疼痛或痉挛性疼痛。
5.偶有发热、荨麻疹。
6.局部不良反应包括注射部位感染、血栓性静脉炎等。 　　
禁忌
遗传性果糖不耐受症、痛风和高尿酸血症患者禁用。警告：使用时应警惕本品过量使用有可能引起危及生命的乳酸性酸中毒，未诊断的遗传性果糖不耐受症患者使用本品时可能有致命的危险。 　　
注意事项
1肾功能不全者、有酸中毒倾向以及高尿酸血症患者慎用。 2本品过量使用可引起严重的酸中毒，故不推荐肠外营养中替代葡萄糖。 3使用过程中应监测临床和试验室指标以评价体液平衡、电解质浓度和酸碱平衡。 4慎用于预防水过多和电解质紊乱。 5过量输注无钾果糖可引起低钾血症。本品不用于纠正高钾血症。 6本品能加剧甲醇的氧化成甲醛，故本品不得用于甲醇中毒治疗。 7使用本品期间，如出现任何不良
药物相互作用
本品不宜与下列药物配伍：氨基已酸、氨苄青霉素、呋喃苯氨酸、硫酸肼苯哒嗪、硫喷妥、华法林等 　　
药理作用
果糖注射液是一种能量和体液补充剂。果糖比葡萄糖更易形成糖原，主要在肝脏通过果糖激酶代谢，易于代谢为乳酸，迅速转化为能量。　　
Package insert
Brand Name
Fructose Note 5% "Fuso"
composition
Fructose Note 20% "Fuso" is an aqueous injection solution of colorless to pale yellow clear, including 1 Poriaru (plastic ampule) 20mL in fructose 4g.
Containing a pH adjusting agent as an additive.
Contraindication
Not metabolized normally hereditary fructose intolerance of patients [fructose, hypoglycemia and the like are expressed, there is a possibility that further liver failure and kidney failure may occur. ]
Hypotonic dehydration of the patient [this disease is caused by the osmotic pressure of the serum is hypotonic by the lack of sodium. Administration of this drug such a patient, results in increasing the water content, there is a risk that symptoms worse. ]
Efficacy or effect
◇ diabetes and energy supply at the time of the diabetic condition
◇ drug addiction, alcohol addiction
◇ If you need other parenterally water and energy supply
◇ dissolution diluent injections
A normal adult once 20~500mL intravenous injection.
Use the appropriate amount of the dissolution dilution of injectables.
It should be noted that, to increase or decrease depending on the patient's age and symptoms.
Careful administration
Appropriate moisture to the patient [this disease of diabetes insipidus, it is necessary to electrolyte management, affect the electrolyte and the like by the administration of this drug, there is a possibility that the symptoms worse. ]
Pharmacology
◇ metabolic pathway 1)
Fructose is primarily metabolized become a fructose-1-phosphate by fructokinase present in the liver. The activity of this enzyme is because they are not affected by the hunger or insulin, fructose is lost from the blood at normal speed in diabetic state.
fructose-1-phosphate is divided into dihydroxy-acetone phosphate and D-glyceraldehyde by further aldolase B, it is introduced into the TCA cycle through the pyruvate. Hereditary fructose intolerance is believed to be due to deficiency of this enzyme.
◇ use in vivo (non-insulin-dependent)
Elimination from fructose in human blood after intravenous infusion is rapid, the blood glucose level also hardly increased, also excreted into urine less than that of glucose, it has been shown to be well bioavailable 2).
Further 3 fructose which have been reported to be metabolized similarly to normal cases in humans diabetes).
That is, the increase in the blood concentration in the case of intravenous injection fructose normal human in less than half the case of glucose, increase in blood pyruvate values ​​are reached approximately 3 times the glucose. Also in human diabetes, an increase of similar blood pyruvate value and normal cases even without insulin unlike glucose, it has been observed disappearance curve in the blood.
◇ protein sparing action 4)
Human dispensed simultaneous static of amino acids and sugars, observation of the nitrogen balance, fructose disappeared than similarly immediately blood and amino acid, it has been reported to exhibit a good nitrogen saving effect than glucose or invert sugar .
◇ detoxification
5 blood alcohol concentration lowering effect of fructose to the control saline solution has been studied). Was injected intravenously at the same time fructose and alcohol intake, increase in blood alcohol concentration is slowly than the control, no significant highs. However, such an action in the case of glucose is not permitted.
Also 6 in chloroform failure isolated rabbit liver, which recognized a significant Rodin yield increase than glucose in fructose, has been suggested to have a liver detoxification ability excellent).
Physicochemical knowledge of active ingredient
Generic name
Fructose
Chemical name
β-D-fructopyranose
Molecular formula
C6H12O6
Molecular weight
180.16
Behavior
In colorless to white crystal or crystalline powder, not the smell, the taste is sweet. Very soluble in water, ethanol sparingly soluble in (95), and practically insoluble in diethyl ether. It is hygroscopic.