部份中文西咪替丁处方资料（仅供参考）
商品名：Tagamet
英文名：Cimetidine
中文名：西咪替丁注射液
生产商：大日本住友制药
タガメット注射液200mg
药用类别名称
H2受体拮抗剂
批准日期：1982年1月
商標名
Tagamet
一般名
シメチジン（Cimetidine）
化学名
2-Cyano-1-methyl-3-{2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl}guanidine
構造式
分子式
C10H16N6S（252.34）
分配係数（水/1-オクタノール系）
pH3.5　0.0
pH5.0　0.1
pH7.0　1.5
pH9.5　2.7
pH11.0 2.6
性状：
白色结晶性粉末, 不气味, 味道苦涩。 易溶于甲醇或醋酸 (100), 几乎不溶于乙醇 (95), 几乎不溶于水, 几乎不溶于乙醚。
溶于稀盐酸。
逐渐被光线染成了颜色。
熔点
140至144°c
药用药理学
1. 胃酸分泌的抑制作用
(1) 基本分泌物
2小时分泌1至3小时后给药200毫克口服口服量为91.2抑制。
(2) 胃泌素、倍他唑和胰岛素刺激分泌物
由200mg 口服, 利乐胃泌素 4μg kg, Betazol 1mg kg, 刺激分泌物由胰岛素0.1u变kg肌醇给药量量为真菌后的分泌量为真菌, 占27.8%, 被抑制。另外, 400毫克口服在同一测试中抑制强烈胃泌素刺激分泌比200mg 口服。
(3) 饮食刺激分泌
刺激分泌由液体蛋白质饮食刺激分泌量是85.7%在第一个小时由200毫克口服给药, 是64.3%抑制在未来1小时。在相同的试验条件下, 硫酸阿托品水合物0.5毫克肌肉的抑制率分别为30.3% 和27.1%。 400毫克口服给予相当于两次的牛两年期刺激与早餐和午餐相对应, 均明显抑制, 效果持续至少8小时(健康人)。
(4) 夜间分泌物
夜间分泌从晚上11点到早上6点71.7在200毫克口服, 是94.0%抑制在300毫克口服, 酸分泌抑制作用的持续时间是4至5小时在200毫克, 并在300毫克6至7小时。
(5) 24小时分泌物
胃汁平均氢离子浓度为24小时, 800毫克(200mx4次) 被口服抑制55%, 也在口服800毫克(400mgx2次), 同样24小时分泌令人满意地得到控制。 夜间比白天的效果在任何使用中都是显著的。
2. 胃蛋白酶分泌物的抑制作用
经200mg 口服, 抑制胰岛素中的胃蛋白酶、胰岛素中的胃蛋白酶分泌物和饮食刺激分泌物约55% 至67%。夜间分泌物的抑制率为2200毫克口服的53.5, 300毫克口服分泌物的81.4。
3. 长期给药导致酸液分泌功能的变化
酸分泌功能, 800 ~1600mg·天, 口服约1至8.5个月, 给药前后无明显变化。此外, 由于西咪替丁给药停药引起的酸反弹也没有观察到。
4. 血液对胃泌素的影响
(1) 口服 800 ~1000mg·天1-4个月给药前后, 空腹血胃素值无明显变化。
(2) 对于饮食刺激后对血液胃泌素的影响, 尚未获得某些观点。
5. 胃泌素细胞数量的变化
1000mg"天 4周, 在20周口服给药, 给药前4周, 开始给药后4周, 12周和24周的吡咯蛋白细胞数量发生重大变化, 但尚未观察到。
6. 胃内容物对分泌物的影响
300mg 口服后 1小时3小时的胃含量放电, 均未观察到显著变化。
7. 胰腺外分泌功能的影响
在800mg"19至24天口服给药前后胰腺外分泌功能无显著性差异。
8. 对胃黏膜电位差异的影响
通过阿司匹林抑制胃黏膜电位差异的降低, 防止黏膜紊乱, 防止胃黏膜屏障衰竭。
9. 胃黏膜 PGE2 生物合成的影响
在口服给药4周内, PGE2的胃黏膜生物合成量比给药前增加 1000mg"天。
适应症
上消化道出血(由消化性溃疡、急性应激性溃疡、出血性胃炎引起)、侵入性应激(手术后需要集中管理的大手术、脑血管疾病、头部外伤、多器官衰竭、严重烧伤等)来抑制上消化道出血和麻醉前药物
用法与用量
0.需要对上消化道出血进行强化护理的上消化道出血(消化性溃疡、急性应激性溃疡、出血性胃炎)、侵入性应激(手术后需要集中管理、脑血管疾病、头部外伤、多器官衰竭、严重烧伤等)
通常成人被稀释到20mL 1200毫克在日间站生理盐水或日间站葡萄糖注射作为西咪替丁, 每天4次(6小时间隔) 被静脉注射缓慢。或混合在输液中滴注静脉。应该注意的是, 年龄, 根据症状增加或减少。一般情况下, 上消化道出血是看到的效果在一周内的表达, 但在它成为可能的口服给药。在通过侵入性应激抑制上消化道出血(手术后需要集中管理的大手术、脑血管疾病、头部外伤、多器官衰竭、严重烧伤等需要重症监护室护理), 术后需要重症监护或重症监护(手术创压应约3天), 其他侵入性压力的使用时间约为7天)。
0.麻醉前药物
通常成人肌肉注射一次200毫克之前, 麻醉引入西咪替丁作为西咪替丁。
包装
注射溶液
200mg: 10安培, 50安培
制造和销售来源
大日本住友制药株式会社
注：以上中文处方资料不够完整，使用者以原处方资料为准。
完整资料附件：http://www.info.pmda.go.jp/go/pack/2325400A1077_4_06/
Tagamet Injection 200mg（Cimetidine タガメット注射液）
Brand name :
Tagamet Injection 200mg
　Active ingredient:
Cimetidine
　Dosage form:
injection
　Print on wrapping:
Effects of this medicine
This medicine blocks histamine H2 receptor of gastric mucosal barrier cells to suppress gastric acid secretion.
It is usually used for upper gastrointestinal bleeding (due to peptic ulcer, acute stress ulcer or hemorrhagic gastritis), suppression of upper gastrointestinal bleeding due to invasive stress (major surgery requiring postoperative management, cerebrovascular disorder/head injury/multi organ failure/severe burn requiring intensive care) and anesthetic premedication.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is ((to be written by a healthcare professional))
For upper gastrointestinal bleeding (due to peptic ulcer, acute stress ulcer or hemorrhagic gastritis): In general, for adults, administer intravenously via slow injection or drip infusion, 4 times a day (every 6 hours). The treatment span depends on your symptoms, however, the normal treatment span is about 7 days.
For suppression of upper gastrointestinal bleeding due to invasive stress (major surgery requiring postoperative management, cerebrovascular disorder/head injury/multi organ failure/severe burn requiring intensive care): In general, for adults, administer intravenously via slow injection or drip infusion, 4 times a day (every 6 hours). The treatment span depends on your symptoms, however, the normal treatment span is about 3 days for invasive stress due to surgery and about 7 days for other invasive stresses.
For anesthetic premedication: In general, for adults, administer intramuscularly an hour before anesthesia.
Precautions while taking this medicine
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include constipation, rash, gynecomastia, milk secretion, increase of white vaginal discharge, erectile dysfunction and peripheral neuropathy (pain/sensory paralysis/motor disorder of the limbs). If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
cold sweat, facial pallor, breathing difficulty [shock, anaphylactoid symptoms]
anemic symptoms, general malaise, sore throat [aplastic anemia, pancytopenia, agranulocytosis, decreased platelets]
fever, rash, decreased urine output [interstitial nephritis, acute renal failure]
fever, loss of appetite, erythema/blister spreading across a wide area [mucocutaneous ocular syndrome, toxic epidermal necrosis]
general malaise, loss of appetite, nausea [liver disorder]
Injection
Revised: 7/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.