部份中文多潘立酮处方资料（仅供参考）
英文名：Domperidone
商品名：Nauzelin Suppository
中文名：多潘立酮栓剂
生产商：协和麒麟公司
药品简介
多潘立酮（Domperidone Suppository）是一种乳白色半固体锥形栓剂，外周多巴胺受体阻滞剂，直接作用于胃肠壁，可增加食道下部括约肌张力，防止胃-食道反流，增强胃蠕动，促进胃排空，协调胃与十二指肠运动，抑制恶心、呕吐，并能有效地防止胆汁反流，不影响胃液分泌。
ナウゼリン坐剤10/ナウゼリン坐剤30/ナウゼリン坐剤60
薬效分类名
消化管运动改善剤
批准日期：1982年9月
商標名
Nauzelin Suppository
一般的名称
ドンペリドン（Domperidone）
化学名
5-Chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
分子式
C22H24ClN5O2
分子量
425.91
性状
白色至微黄色结晶性粉末或粉末（无臭，味微苦）。
化学结构式
熔点
约243°C（分解）
分配系数
logP'OCT=3.20
（测量方法：烧瓶振荡法，正辛醇/pH 7.4缓冲溶液）
溶解度
它可自由溶于乙酸（100），难溶于甲醇或乙醇（99.5），极难溶于2-丙醇，几乎不溶于水。
药效药理
作用机理
它作用于上消化道和CTZ（化学受体触发带），并通过抗多巴胺作用发挥其药效。
对胃肠动力的影响
促进胃动力
胃的节律性收缩力在较长时间（约2小时）内增加，而不会影响收缩频率和张力（狗）。
胃/十二指肠协调运动促进作用
在增加胃的自动运动的同时，它显着促进了胃窦-十二指肠的协调（豚鼠提取的胃）。
正常胃排空
在对各种上消化道疾病患者的研究中，它在胃排空延迟的情况下（包括胃溃疡病例）促进胃排空，而在胃肠道增加的情况下则起到抑制作用。胃引流正常。
食管下括约肌压力升高（LESP）
这种药物的LESP增强作用持续时间比胃泌素和胆碱能药物（狗和人）更长。
选择性止吐作用
低剂量（狗）可抑制由刺激位于第四脑室底部的CTZ引起的各种药物（阿扑吗啡，左旋多巴，吗啡等）引起的呕吐。在诸如条件回避反应等对中枢神经系统的作用的ED 50与止吐作用的ED 50之间观察到极大的分离，表现出选择性的止吐作用。
适应症
栓剂60
成人：
服药期间出现以下疾病和胃肠道症状（恶心，呕吐，食欲不振，腹胀，上腹部不适，胸烧）
胃十二指肠手术后
服用抗肿瘤药时
栓剂10，栓剂30
儿童：
服药期间出现以下疾病和胃肠道症状（恶心，呕吐，食欲不振，腹胀，腹痛）
定期呕吐，婴儿腹泻，上呼吸道感染
服用抗肿瘤药时。
用法与用量
栓剂60
成人：
通常的剂量是每天两次直肠内给予60 mg的哌替啶。
剂量可以根据年龄和症状进行调整。
栓剂10，栓剂30
儿童：
对于3岁以下的儿童，通常每天2-3次直肠内给予10mg哌替啶。
对于3岁及以上的年龄，通常每天2-3次直肠内给予30毫克的哌替啶。
剂量可以根据您的年龄，体重和症状进行调整。
包装
栓剂
10mg：20個（5個x4）
30mg：20個（5個x 4）
60mg：20個（5個x 4）
制造商和分销商
协和麒麟有限公司
注：以上中文处方资料不够完整，使用以原处方资料为准。
完整说明资料附件：
https://www.info.pmda.go.jp/go/pack/2399714J1026_1_14/
NAUZELIN Suppository 30（ナウゼリン坐剤30）
Brand name : NAUZELIN Suppository 30
　Active ingredient: Domperidone
　Dosage form: white to yellowish white suppository, maximum diameter: approx. 8 mm, length: approx. 25 mm
　Print on wrapping: KH309 30mg ナウゼリン 
Effects of this medicine
This medicine suppresses activities of dopamine in the stomach and duodenum to improve gastrointestinal motility, and acts on CTZ (chemoreceptor trigger zone) involved in causing nausea to suppress nausea.
It is usually used to treat nausea in postoperative periods of the gastric and duodenal surgery.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have: gastrointestinal bleeding, mechanical ileus, gastrointestinal perforation, prolactinoma, hepatic disorder or renal disorder.
•If you are pregnant, possible pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adult, insert 1 suppository (60 mg of the active ingredient) into the rectum at a time, twice daily. The dosage may be adjusted according to the age or symptoms. Strictly follow the instructions.
•If you miss a dose, use a dose as soon as possible when the symptom of nausea is severe. Wait more than 7 hours to use a next dose. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.You should never use two doses at one time.
•If you accidentally use more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop using this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•This medicine may cause sleepiness and dizziness. Take care in driving a car or engaging in dangerous activities.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include diarrhea, defecation desire, anal discomfort, strange sensation when suppository is inserted, hepatic dysfunction and gynecomastia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•dizziness, orthostatic dizziness, cold sweat, facial pallor [shock]
•breathing difficulty, hives, swelling around eyes and mouth [anaphylactoid symptoms]
•tremor of limbs, muscle stiffness, twist or cramp in neck, upward rotation of eyes [extrapyramidal symptoms]
•decreased consciousness, sudden muscle contraction [consciousness disorder, convulsion]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
Kyowa Hakko Kirin Co.,LtdExternal
Revised: 7/2012
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.