部份中文硫糖铝处方处方资料（仅供参考）
英文药名: Carafate(Sucralfate)
中文药名: 硫糖铝
药理作用
在酸性环境下，可离解为带负电荷的八硫酸庶糖，聚合成胶体，保护胃粘膜，然而确切的作用机制尚未完全清楚。能与溃疡或炎症处的带正电荷的渗出蛋白质结合，在溃汤面或炎症处形成一薄膜，保护溃疡或炎症粘膜抵御胃酸的侵袭。此外，硫糖铝能吸附胃蛋白酶及中和胃酸，但作用弱。硫糖铝还能吸附唾液中的表皮生长因子，浓集于溃疡处，促进愈合，也能剌激前列腺素E的合成，刺激表面上皮分泌碳酸氢根及起细胞保护作用。
适应症
用于治疗胃十二指肠溃疡及胃炎。
用法用量
成人常用量：一次1g，一日4次，餐前1小时及睡前嚼碎后服。
小儿遵医嘱。
给药说明
(1)硫糖铝必须空腹摄入，餐前1小时与睡前服用效果最好。嚼碎与唾液搅和，或研成粉末后服下能发挥最大效应。
(2)本品短期治疗即可使溃疡完全愈合，但愈合后复发仍属可能;本品对严重十二指肠溃疡效果较差。
(3)临床如有需要，为缓解溃疡疼痛可合并应用制酸药，但后者须在硫糖铝服前半小时或服后1小时给予。
(4)每一疗程为4-8周，配合X线或内镜检查观察溃疡愈合与否。
(5)连续应用不宜超过8周。
防止便秘，可适当加服轻泻药。治疗收效后，应继续服药数月，以免复发。任何疑问，请遵医嘱!
不良反应
较常见的是便秘；少见或偶见的有腰痛、腹泻、眩晕、昏睡、口干、消化不良、恶心、皮疹、瘙痒以及胃痉挛。
个别病例口干，恶心，便秘，剧烈胃痛，长期使用大剂量可出现铝中毒。硫糖铝引起血浆内磷酸盐含量下降，长期使用可能出现骨软化。
禁用/慎用
肾功能不全的病人，服用疏糖铝后，血浆中铝的含量增加，虽不能确定长期用药后铝在体内的蓄积情况，但应小心使用。
药物相互作用
(1)制酸药可干扰硫糖铝的药理作用，硫糖铝也可减少西咪替丁的吸收。
(2)硫糖铝可干扰脂溶性维生素(维生素 A、D、E和 K)的吸收。
本品能与胃蛋白酶形成复合物，多酶片中含有胃蛋白酶，因此两药不宣合用。本品亦可减少西咪替丁的吸收。
硫糖铝对共服的其他药物有明显的相互作用，可以减少华法林(也可能还有苯妥英、地高辛、四环素等)的吸收，当两者共同服用时，华法林的抗凝血活性降低50%。
CARAFATE SUSPENSION (Sucralfate)
Carafate is used for:
Treating and preventing ulcers. It may also be used for other conditions as determined by your doctor.
Carafate is a gastric protective. It works by forming a protective layer on the ulcer to serve as a barrier against acid, bile salts, and enzymes in the stomach.
Before using Carafate :
Some medical conditions may interact with Carafate . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have kidney problems or are on dialysis, or have blockage of the intestines or difficulty swallowing
Some MEDICINES MAY INTERACT with Carafate . Tell your health care provider if you are taking any other medicines, especially any of the following:
Citrate salts or medicines that contain aluminum, specifically in patients with kidney disease, because side effects from aluminum buildup may occur
How to use Carafate :
Use Carafate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Carafate by mouth on an empty stomach at least 1 hour before or 2 hours after eating.
Do not take an antacid for at least 30 minutes before or after taking Carafate .
It may take 4 to 8 weeks for complete healing of your ulcer. Continue taking Carafate for the full course of treatment even if you feel better.
Do not take Carafate at the same time as other medicines. Take Carafate at least 2 hours after other medicines. If you are not sure about the best time to take Carafate , ask your doctor or pharmacist.
If you miss a dose of Carafate , take it as soon as possible. If it is almost time for your next dose, go back to your regular dosing schedule. Do not take 2 doses at once.
Important safety information:
Carafate may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Take Carafate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Carafate has aluminum in it. Before you start any new medicine, check the label to see if it has aluminum in it too. If it does or if you are not sure, check with your doctor or pharmacist.
Carafate should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Carafate while you are pregnant. It is not known if Carafate is found in breast milk. If you are or will be breast-feeding while you take Carafate , check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Carafate :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; dizziness; feeling of a whirling motion.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).
General information:
If you have any questions about Carafate , please talk with your doctor, pharmacist, or other health care provider.
Carafate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.