部份中文枸橼酸莫沙必利处方资料（仅供参考）
英文名：Mosapride Citrate Hydrate
商品名：GASMOTIN
中文名：枸橼酸莫沙必利
生产商：住友制药
ガスモチン錠5mg/ガスモチン錠2.5mg/ガスモチン散１％
药用类别名称
消化道运动功能改善剂
批准日期：1998年9月
商標名
GASMOTIN
一般名
モサプリドクエン酸塩水和物
Mosapride Citrate Hydrate
化学名
4-Amino-5-chloro-2-ethoxy-N-{[(2RS)-4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide monocitrate dihydrate
分子式
C21H25ClFN3O3・C6H8O7・2H2O
分子量
650.05
分配係数
9.1×102(クロロホルム/水系溶媒、pH7.0、室温)
性状
是一种白色带淡黄色的结晶性粉末。 N, 溶于 n-二甲基甲酰胺或乙酸 (100), 几乎不溶于甲醇, 几乎不溶于乙醇 (99.5), 几乎不溶于水。 N, n-二甲基甲酰胺溶液 (1→20) 不具有光转特性。
药用药理学
1. 临床药理学
在健康成人和慢性胃炎患者的胃分泌试验中, 我显示胃分泌物在该制剂5mg 一旦给药后的促进作用。
2. 上消化道运动促进作用
(1) 促进行动的胃、十二指肠运动
剂量依赖性, 食物晚胃, 表示十二指肠运动促进行动 (狗)。
(2) 促进胃分泌的作用
胃分泌物对液体 (小鼠、大鼠) 的促进作用, 并显示固体 (大鼠) 的胃分泌物促进作用。 此外, 胃分泌促进作用在重复给药一个星期被减弱 (大鼠)。
3. 下消化道运动促进行动
(1) 结肠运动和内容物运输促进的操作
剂量依赖性显示结肠运动和内容运输促进行动 (豚鼠)。
(2) 结肠清洁增强效果和减轻水分重量的作用 (使用口腔肠道清洁剂时) 13
口服肠道清洁剂 (Nifrec 复合剂), 通过给药增强结肠的清洁效果, 进一步降低结肠 (豚鼠) 的水重。
4. 作用机制
该制剂是一种选择性血清素5-HT4 受体激动剂, 刺激胃肠道内源性神经丛中存在的5-HT4 受体, 相信通过增加乙酰胆碱免费, 表现出上、下胃肠动力促进作用。
适应症
0 与慢性胃炎相关的胃肠道症状 (胸部、恶心、呕吐)
0 口服肠道清洁剂辅助治疗钡灌肠x线
用法与用量
0 与慢性胃炎相关的胃肠道症状 (胸部、恶心、呕吐)
通常情况下, 成人, 在饭后或饭后口服三次, 每天15毫克作为柠檬酸苔藓。
0 口服肠道清洁剂辅助治疗钡灌肠x线
通常情况下, 成人, 口服20mg 作为一种莫普停数盐在口服肠道清洁剂开始给药(约 180mL)。 此外, 口服肠道清洁剂给药后, 口服少量水20mg作为柠檬酸苔藓盐。
临床结果
1. 与慢性胃炎相关的胃肠道症状 (胸部、恶心、呕吐)
共有435例临床结果, 包括双盲比较试验 7) 见表3。
2. 协助口服肠道清洁剂进行钡灌肠x线成像的预处理
共99例患者在钡灌肠x线对比试验8中与布朗变种进行了比较试验。 因此, 目前的制剂和口服肠道清洁剂 (Nifrec 复合剂) 组合组 "右结肠钡粘连评分" 和 "右结肠大便残留量得分", 证实不低于布朗变种组。
包装
片
5mg: [PTP] 100片 (10片x10), 1,000片 (10片x100), 1,050片(21片x50)
[瓶装] 1,000 片
2.5mg: [PTP] 100片(10片x10)
散 1%: [最小]
300 克(0.5gx600)
[瓶装]100 克, 500克
制造和销售来源
大日本住友制药株式会社
注：以上中文资料不够完整，使用者以原处方资料为准。
完整说明资料附件：http://www.info.pmda.go.jp/go/pack/2399010B1034_1_10/ 
GASMOTIN Tablets 5mg（ガスモチン錠5mg）
Brand name : GASMOTIN Tablets 5mg
　Brand name : GASMOTIN Tablets 5mg
　Active ingredient: Mosapride citrate hydrate
　Dosage form: white tablet (major axis: 9.2mm, minor axis: 4.7mm, thickness: 3.7mm)
　Print on wrapping: ガスモチン錠,5mg, P218
Effects of this medicine
This medicine stimulates serotonin receptor in the digestive tract and increases acetylcholine release in order to improve functions of enterokinesis and gastric emptying.
It is usually used to treat heartburn, nausea and vomiting caused by chronic gastritis and adjunctive treatment to the pretreatment with orally gastrointestinal lavage solution for barium enema X-ray examination.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•For the treatment of heartburn, nausea/vomiting associated with chronic gastritis. In general, for adults, take 2 tablets (5mg of mosapride citrate) at a time, 3 times a day, before or after meal. Strictly follow the instructions .
For the treatment of adjunctive treatment to the pretreatment with orally gastrointestinal lavage solution for barium enema X-ray examination. In general, for adults, take 8 tablets (20mg of mosapride citrate) with the orally gastrointestinal lavage solution (approx. 180mL) at the time of administration of the lavage solution, and take 8 tablets with a small amount of water after administration of the lavage solution.
•For heartburn, nausea/vomiting associated with chronic gastritis, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally took more than your prescribed dose,consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most reported adverse reaction include diarrhea/loose stool, dry mouth, abdominal pain, lassitude, rash, hives, nausea, feeling of fullness, headache, etc. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•generalized fatigability, loss of appetite, yellowness in the skin and the conjunctiva [fulminant hepatitis, liver dysfunction, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from heat, moisture and direct sunlight.
•Discard the remainder. Do not store them.
Sumitomo Dainippon Pharma Co.,Ltd.Internal
Revised: 7/2012
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/2399010B1034_1_09/