部份中文脂肪乳处方资料（仅供参考）
商品名：Intralipid 20% Injection
英文名：Fat Emulsion
通用名：脂肪乳注射液
生产商：百特医疗
药品简介
Intralipid（20%I.V.脂肪乳剂）是一种无菌、无热原的脂肪乳剂，用作药剂混合计划中的热量和必需脂肪酸来源。它由20%大豆油、1.2%蛋黄磷脂、2.25%甘油和注射用水组成。此外，加入氢氧化钠以调节pH值，使最终产品的pH值为8。pH值范围为6至8.9。
Intralipid 20%药房散装包装不适用于直接输液。它是一种无菌剂型，包含多个单一剂量，用于在药物混合物项目中制备三合一或全营养混合物（TNA）。
临床药理学
内脂被代谢并用作能量来源，导致产热量增加、呼吸商降低和耗氧量增加。注入的脂肪颗粒以被认为与乳糜微粒清除相当的方式从血流中清除。
Intralipid将预防原发性脂肪酸缺乏症（EFAD）的生化损害，并纠正EFAD综合征的临床表现。
适应症和用法
Intralipid®20%药剂散装包装适用于配制三合一或全营养混合物（TNA）的药剂混合计划，为长期（通常超过5天）需要肠外营养的患者提供热量和必需脂肪酸来源，并为预防EFAD提供必需脂肪酸源。
剂量和给药
20%Intralipid（20%I.V.脂肪乳剂）大剂量药剂包只能作为三合一或全营养混合物的一部分通过外周静脉或中心静脉输注。
成年患者
在输注的前15至30分钟，成人营养混合物的初始输注速率应为0.1克脂肪/分钟。如果没有发生不良反应（见不良反应一节），可将输注速度提高到0.2克脂肪/分钟。
对于成人，在治疗的第一天，混合物中的Intralipid含量不应超过500mL 20%。如果患者没有不良反应，可在第二天增加剂量。每日剂量不应超过2.5克脂肪/千克体重（12.5毫升Intralipid 20%/千克）。20%的Intralipid应不超过患者总热量输入的60%。
最大输注速率不应超过0.1 g/kg/hr。
碳水化合物和氨基酸来源应构成剩余的热量输入。
儿科患者
早产儿的剂量从0.5g脂肪/kg体重/24小时（2.5mL Intralipid 20%）开始，可能会随着婴儿消除脂肪的能力而增加。最大推荐剂量为3 g脂肪/kg/24小时。
当接受Intralipid治疗超过两周时，儿童患者可能面临肠外营养相关肝病（PNALD）的风险，也称为肠衰竭相关肝病。静脉注射20%Intralipid期间，进行肝脏检查以监测PNALD。
在最初的10至15分钟内，老年儿童患者的初始输注速度应不超过0.01g脂肪/分钟。如果没有出现不良反应，可以改变速率，以允许每千克/小时输注0.1克脂肪。每日剂量不应超过每千克体重3克脂肪。Intralipid（相当于0.125克/千克/小时）应不超过患者总热量输入的60%。碳水化合物和氨基酸来源应构成剩余的热量输入。
原发性脂肪酸缺乏症
当使用20%的Intralipid来纠正必需脂肪酸缺乏症时，20%的Introlipid应提供8%至10%的热量输入，以提供足量的亚油酸和亚麻酸。当EFAD与应激一起发生时，纠正缺陷所需的20%Intralipid量可能会增加。
禁忌症
以下患者禁用Intralipid：
正常脂肪代谢紊乱，如病理性高脂血症、类脂肾病或急性胰腺炎（如果伴有高脂血症）。已知对鸡蛋、大豆、花生蛋白或20%Intralipid中的任何活性成分或赋形剂过敏。
intrilipid 20%药剂散装包装不适用于直接静脉给药。用静脉内液体如生理盐水或其他稀释剂将20%的脂质内稀释至10%的浓度不会产生与10%的脂质内静脉注射脂肪乳剂在组成上等同的稀释液，并且这种稀释液不应通过直接静脉注射给予。
包装提供/储存和处理
提供
20%的Intralipid以无菌乳剂的形式提供，装在1000毫升药剂散装包装中。
1000毫升NDC 0338-0519-14
20% Intralipid也有以下填充尺寸：
100毫升：0338-0519-58
250毫升：0338-0519-09
500毫升：0338 0519-13
存储
20%的Intralipid不得储存在25°C（77°F）以上。不要冷冻20%的Intralipid。如果意外冷冻，丢弃袋子。
请参阅随附的INTRALIPID完整处方信息：
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=55609586-f0b4-42e6-8dd9-cd090afb5dca
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注：以下产品价格不包括发票、运费等其他费用。仅供研究，医院！
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INTRALIPID 20% 1000ML 2B6064 6  FAT EMULSIONS 持证商：BAXTER GENERAL HEALTHCARE  NDC:00338-0519-14 参考价格（美元）：538.79
INTRALIPID 20% 500ML 2B6063 12  FAT EMULSIONS 持证商：BAXTER GENERAL HEALTHCARE  NDC:00338-0519-13 参考价格（美元）：611.16
INTRALIPID 20% 250ML 2B6062 10  FAT EMULSIONS 持证商：BAXTER GENERAL HEALTHCARE  NDC:00338-0519-09 参考价格（美元）：576.18
INTRALIPID 20% 100ML 2B6061 10  FAT EMULSIONS 持证商：BAXTER GENERAL HEALTHCARE  NDC:00338-0519-58 参考价格（美元）：376.66
INTRALIPID 20% 1000ML 2B6024 6  FAT EMULSIONS 持证商：BAXTER GENERAL HEALTHCARE  NDC:00338-0519-04 参考价格（美元）：769.7
INTRALIPID 20% 100ML 2B6030 10  FAT EMULSIONS 持证商：BAXTER GENERAL HEALTHCARE  NDC:00338-0519-48 参考价格（美元）：538.08
INTRALIPID 20% 250ML 2B6022 10  FAT EMULSIONS 持证商：BAXTER GENERAL HEALTHCARE  NDC:00338-0519-02 参考价格（美元）：561.52
INTRALIPID 20% 500ML 2B6023 12  FAT EMULSIONS 持证商：BAXTER GENERAL HEALTHCARE  NDC:00338-0519-03 参考价格（美元）：873.06
INTRALIPID 30% 500ML 2B6065 12  FAT EMULSIONS 持证商：BAXTER GENERAL HEALTHCARE  NDC:00338-0520-13 参考价格（美元）：911.79
INTRALIPID 30% 500ML 2B6053 12  FAT EMULSIONS 持证商：BAXTER GENERAL HEALTHCARE  NDC:00338-0520-03 参考价格（美元）：1302.54
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Intralipid-Patients needing IV nutrition to supply energy and essential fatty acids; patients with essential fatty acid deficiency(EFAD)who cannot maintain or restore a normal essential fatty acid pattern by oral intake.
Indications:
lipid infusion for parenteral nutrition As a source of energy and essential fatty acids for patients requiring IV nutrition. Pre- and postoperative nutritional disturbances in which a large supply of energy is necessary or desirable eg, in order to improve the nitrogen balance. Nutritional disorders or disturbances of nitrogen balance due to inadequate or failing intestinal absorption caused by tumours in the gastrointestinal tract, acute or chronic intestinal diseases(peritonitis, ulcerative colitis, terminal ileitis) and others.
Burns, in extensive burns, every additional supply of energy is of value as a means of reducing the frequently excessive nitrogen losses.
A large supply of energy also improves the utilization of orally ingested protein as well as of infused Vamin.
IV administered fat is also indicated in patients in whom oral nutrition is inadequate. Prolonged unconsciousness eg, following cranial traumata or poisoning in cases where tube feeding is inappropriate or impossible. Impaired renal function, in which condition an adequate supply of energy is essential to reduce protein breakdown.
Cachexia. Emulsions of fractionated soya oil containing 10, 20, or 30% are given by slow intravenous infusion as part of total parenteral nutrition regimens, usually with amino acid and carbohydrate solutions. The solutions and emulsions may be given at separate sites, at the same site through a Y-connector, or combined in one admixture.Fat emulsions provide a high energy intake in a relatively small volume.They may also be used to prevent or correct essential fatty acid deficiency.
When used as a calorie source the dose of the emulsion is determined by the energy requirements and clinical status of the patient; the amount of total carbohydrate, generally, should not comprise more than 60% of patients’ total calorie intake. For the prevention and correction of fatty acid deficiency about 5 to 10% of total calorific intake should be as an intravenous fat emulsion. The composition and dosage recommendations of commercial preparations do differ slightly but they should be started slowly. Suggested initial rates for the 10% and 20% products are 1 mL/minute and 0.5 mL/minute respectively for 15 to 30 minutes.
The rate may then be increased and up to about 500 mL (or 10 mL/kg) of 10% or 250 mL (or 5 mL/kg) of 20% emulsion may be given on the first day. The total daily dosage may then be increased gradually on subsequent days; suggested daily dose ranges are 500 to 1500 mL of a 10% or 500 to 1000 mL of a 20% emulsion and suggested rates of infusion are 500 mL of a 10% emulsion over a period of not less than 3 hours, and 500 mL of a 20% emulsion over not less than 5 hours.
Where a 30% emulsion is used, a dose of 333 mL or about 4.75 mL/kg has been recommended, given over 5 hours or more; the first dose should not exceed 3 mL/kg. Soya oil also has emollient properties and is used as a bath additive in the treatment of dry skin conditions. Supply of energy & essential fatty acids as IV solution